Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats
Abstract
Background/aims The aim of this study was to investigate the effect of ascorbic acid (AA) an alterations in hepatic secretory and microsomal functions during hepatic ischemia and reperfusion.Methods Rats were subjected to 60 min of hepatic ischemia, and 1 and 5 h of reperfusion. Five minutes prior to ischemia, the animals were administered either vehicle or ascorbic acid (AA) (30, 100, 300, and 1000 mg/kg) intravenously.Results The serum aminotransferase level and lipid peroxidation were markedly higher as a result of ischemia/reperfusion. These increases were significantly attenuated by AA doses of 30 and 100 mg/kg but were augmented by dose of 1000 mg/kg. Bile flow and cholate output were markedly decreased by ischemia/reperfusion. AA doses of 30 and 100 mg/kg restored but dose of 1000 mg/kg inhibited their secretion. Both the cytochrome P(450) content and aminopyrine N-demethylase activity were decreased by ischemia/reperfusion, which were prevented by AA doses of 30 and 100 mg/kg but were aggravated by dose of 1000 mg/kg. Aniline p-hydroxylase activity was elevated by ischemia/reperfusion, and this was prevented by AA doses of 100, 300 and 1000 mg/kg.Conclusions Ischemia/reperfusion diminishes the hepatic secretory and microsomal functions. AA has both antioxidant and pro-oxidant effects, depending upon the dose.
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Multiple studies showed no effect of vitamin C on markers of lipid peroxidation in healthy humans or animals.
“Multiple studies showed no effect of vitamin C on markers of lipid peroxidation in healthy humans or animals [63,66,166].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [166]
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- Authors
- Seo, M.-Y., & Lee, S.-M.
- Affiliations
- Sungkyunkwan University (KR)
- Corresponding author
- Lee, Sun-Mee
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 36
- Issue
- 1
- Pages
- 72-77
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2043649744
- Cited by
- 131
- References
- 29
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- vitamin C, hepatic ischemia-reperfusion, hepatoprotection, hepatobiliary function, bile flow, lipid peroxidation, transaminases, cytochrome P450, aminopyrine N-demethylase, dose-dependent effects, liver microsomal enzymes
- MeSH terms
- Alanine Transaminase, Aminopyrine N-Demethylase, Animals, Antioxidants, Ascorbic Acid, Bile, Cytochrome P-450 Enzyme System, Liver, Male, Microsomes, Liver, Lipid Peroxidation, Reperfusion Injury, Rats, Sprague-Dawley, Rats
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