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Cited by 131Organ Transplantation Techniques and OutcomesVitamin C and Antioxidants ResearchDrug-Induced Hepatotoxicity and Protection

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats

Seo, Min-Young, Lee, Sun-Mee·2002·Journal of Hepatology
DOI 10.1016/s0168-8278(01)00236-7
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Abstract

Background/aims The aim of this study was to investigate the effect of ascorbic acid (AA) an alterations in hepatic secretory and microsomal functions during hepatic ischemia and reperfusion.Methods Rats were subjected to 60 min of hepatic ischemia, and 1 and 5 h of reperfusion. Five minutes prior to ischemia, the animals were administered either vehicle or ascorbic acid (AA) (30, 100, 300, and 1000 mg/kg) intravenously.Results The serum aminotransferase level and lipid peroxidation were markedly higher as a result of ischemia/reperfusion. These increases were significantly attenuated by AA doses of 30 and 100 mg/kg but were augmented by dose of 1000 mg/kg. Bile flow and cholate output were markedly decreased by ischemia/reperfusion. AA doses of 30 and 100 mg/kg restored but dose of 1000 mg/kg inhibited their secretion. Both the cytochrome P(450) content and aminopyrine N-demethylase activity were decreased by ischemia/reperfusion, which were prevented by AA doses of 30 and 100 mg/kg but were aggravated by dose of 1000 mg/kg. Aniline p-hydroxylase activity was elevated by ischemia/reperfusion, and this was prevented by AA doses of 100, 300 and 1000 mg/kg.Conclusions Ischemia/reperfusion diminishes the hepatic secretory and microsomal functions. AA has both antioxidant and pro-oxidant effects, depending upon the dose.

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Crossref · 10.1016/s0168-8278(01)00236-7

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Metadata

Authors
Seo, M.-Y., & Lee, S.-M.
Affiliations
Sungkyunkwan University (KR)
Corresponding author
Lee, Sun-Mee
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2002-01
Volume
36
Issue
1
Pages
72-77
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/s0168-8278(01)00236-7
OpenAlex
W2043649744
Cited by
131
References
29
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
3.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
vitamin C, hepatic ischemia-reperfusion, hepatoprotection, hepatobiliary function, bile flow, lipid peroxidation, transaminases, cytochrome P450, aminopyrine N-demethylase, dose-dependent effects, liver microsomal enzymes
MeSH terms
Alanine Transaminase, Aminopyrine N-Demethylase, Animals, Antioxidants, Ascorbic Acid, Bile, Cytochrome P-450 Enzyme System, Liver, Male, Microsomes, Liver, Lipid Peroxidation, Reperfusion Injury, Rats, Sprague-Dawley, Rats

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