Cited by 237biodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applicationsPolymer Science and PVC

Kinetics and Time−Temperature Equivalence of Polymer Degradation

Lyu, Schley, James, Loy, Brian, Lind, Deanna, Hobot, Christopher, Sparer, Randall, Untereker, Darrel·2007·Biomacromolecules

Abstract

We studied the hydrolysis kinetics of amorphous polylactide. It was found the hydrolysis rate had a slow-to-fast transition at a certain molecular weight (Mn). This transition was not correlated with the mass loss and water uptake of samples, nor the pH values of testing media. We speculated that this transition was due to the slow diffusion of polymer chain ends. The chain ends did not significantly promote the hydrolysis of samples until their concentrations (approximately 1/Mn) reached a critical value. The degradation tests were also conducted over a temperature range from 37 to 90 degrees C. A time-temperature equivalent relationship of degradation processes was established and a master curve spanning a time range equivalent to 3-5 years at 37 degrees C was constructed. This master curve can be used to predict polymer degradation processes based on accelerated tests. The functional time and disappearance time of degradable polymers were also discussed.

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Crossref · 10.1021/bm070313n

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38 of 38 references verified0 citation errors · 0 not checkable

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  • The rate of water diffusion depends on the hydrophobicity of the polymer and its shape or surface area while the intrinsic degradation kinetics is affected by the pH and temperature of the medium as well as the molecular weight and microstructures of the polymer.

    “The rate of water diffusion depends on the hydrophobicity of the polymer and its shape or surface area while the intrinsic degradation kinetics is affected by the pH 421 and temperature of the medium 422 as well as the molecular weight 423 and microstructures of the polymer.424”

    From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [422]

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Authors
Lyu, Schley, J., Loy, B., Lind, D., Hobot, C., Sparer, R., & Untereker, D.
Affiliations
Medtronic (United States) (US)
Corresponding author
Lyu
Venue
Biomacromolecules
Published
2007-06-19
Volume
8
Issue
7
Pages
2301-2310
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2008881670
Cited by
237
References
38
Citations by year
2026: 14 · 2025: 25 · 2024: 16 · 2023: 24 · 2022: 14 · 2021: 17 · 2020: 19 · 2019: 14 · 2018: 8 · 2017: 18 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 9
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Locations
  • Biomacromolecules (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer Science and PVC
Keywords
polylactic acid, hydrolysis kinetics, time-temperature superposition, master curve, accelerated degradation testing, molecular weight dependence, amorphous polymers, degradable polymers, functional time
MeSH terms
Hydrogen-Ion Concentration, Hydrolysis, Kinetics, Polymers, Temperature

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