Reducing Intestinal Nematode Infection: Efficacy of Albendazole and Mebendazole
Abstract
The widespread use of mebendazole and albendazole for treating intestinal nematode infections in human populations is raising concerns that careful monitoring pro- cedures should be in place to identify any emergence of drug resistance. In this article, Andy Bennett and Helen Guyatt discuss whether benchmark parasitological drug efficacy rates can be defined for these anthelmintics, by analysing published data on cure rates and egg reduction rates in the treatment of Ascaris lumbricoides, Trichuris trichiura and hookworm.
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As to T. trichiura infection, Bennett and Guyatt reviewed literature on the efficacy of albendazole and mebendazole and found that the CR of albendazole (400 mg single dose) was markedly lower in Asia than in Africa, Central and South America (33.3% vs 61.0%, respectively) probably due to a drug resistance.
“As to T. trichiura infection, Bennett and Guyatt [336] reviewed literature on the efficacy of albendazole and mebendazole and found that the CR of albendazole (400 mg single dose) was markedly lower in Asia than in Africa, Central and South America (33.3% vs 61.0%, respectively) probably due to a drug resistance.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [336]
Regarding human-infecting intestinal nematodes, such as hookworms, the emergence of drug resistance has been suggested by various workers, including Bennett and Guyatt.
“Regarding human-infecting intestinal nematodes, such as hookworms, the emergence of drug resistance has been suggested by various workers, including Bennett and Guyatt [336].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [336]
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- Authors
- Bennett, A., & Guyatt, H.
- Affiliations
- University of Oxford (GB)
- ORCID
- Guyatt, H
- Venue
- Parasitology Today
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 16
- Issue
- 2
- Pages
- 71-77
- ISSN
- 0169-4758 (ISSN-L)
- OpenAlex
- W2059686232
- Cited by
- 155
- References
- 11
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parasitology Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- intestinal nematode infection, albendazole, mebendazole, anthelmintic efficacy, drug resistance, Ascaris lumbricoides, Trichuris trichiura, hookworm, cure rate, egg reduction rate
- MeSH terms
- Ancylostoma, Animals, Anthelmintics, Ascariasis, Feces, Hookworm Infections, Humans, Mebendazole, Trichuriasis, Trichuris, Albendazole, Ascaris lumbricoides, Necator americanus
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