Mapping phenotypes: canalization, plasticity and developmental stability
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This form of selection bias is likely particularly problematic for studies of harmful exposures on disease outcomes that occur in later life and will be least evident in studies where the exposure does not affect survival to recruitment.
“This form of selection bias is likely to be particularly problematic for studies of harmful exposures on disease outcomes that occur in later life and will be least evident in studies where the exposure does not affect survival to recruitment.176”
From Mendelian randomization (2022) · cites this paper as [176]
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“Simultaneous promotion of both plasticity and genetic canalization would result in canalized reaction norms ( Debat & David, 2001 ).”
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“Selection for reduced environmental variance could result in environmental canalization, a phenomenon of long-standing interest (e.g., Waddington 1942, 1960; reviews in Scharloo 1991, Debat and David 2001, and Flatt 2005).”
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“Genes responsible for genetic-canalizing effects are assumed to decrease visible additive genetic variance, whereas genes with environment-canalizing effects would decrease environmental variance (Debat and David 2001).”
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BackgroundA Single Basis for Developmental Buffering of Drosophila Wing Shape
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“…change in response to a change in environment; canalization—the ability to produce a consistent phenotype in spite of genetic and environmental influences; and developmental stability—the buffering of random developmental errors, has generated some debate (e.g., Debat and David 2001; Flatt 2005).”
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“This trend is consistent with environmental canalization Debat and David 2001, Wagner et al. 1997 for an optimum height in species that inhabit the most extreme range in salinities which is relaxed in species that inhabit intermediate ranges of salinities.”
ResultStrengthening causal inference in cardiovascular epidemiology through Mendelian randomization
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“Ecologists often use the term ‘reaction norm’ (see Glossary) to describe a set of phenotypes produced by a single genotype under different environmental conditions (Debat and David, 2001), i.e. the reaction to an environment.”
BackgroundLachowiec, J., Queitsch, C., & Kliebenstein, D. J. (2015) · Annals of Botany · doi:10.1093/aob/mcv151 · Cited by 104 · see citing works
It’s not magic – Hsp90 and its effects on genetic and epigenetic variation
Zabinsky, R. A., Mason, G. A., Queitsch, C., & Jarosz, D. F. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.015 · Cited by 104 · see citing works
Phenotypic Plasticity and Selection: Nonexclusive Mechanisms of Adaptation
Grenier, S., Barré, P., & Litrico, I. (2016) · Scientifica · doi:10.1155/2016/7021701 · Cited by 102 · see citing works
“For a given trait, this change with environment can be continuous or discrete [37].”
BackgroundTonsor, S. J., Elnaccash, T. W., & Scheiner, S. M. (2013) · Evolution · doi:10.1111/evo.12175 · Cited by 100 · see citing works
“Debat and David (2001) point out that many of the terms we use in studies of both development and adaptation to environmental variation (e.g., plasticity, genotype-by-environment interaction, developmental instability) do not take into account recent advances in our understanding of underlying…”
BackgroundSexual Selection and Conflict as Engines of Ecological Diversification
Russell Bonduriansky, A. (2011) · The American Naturalist · doi:10.1086/662665 · Cited by 101 · see citing works
“…a sexual signal acquires a viability-related function (e.g., as an aposematic signal), this may generate strong stabilizing selection on the signal (Debat and David 2001; Siegal and Bergman 2002), and at the same time the signal may become less costly to express because it enhances rather than…”
BackgroundEVOLUTION AND DETECTION OF GENETIC ROBUSTNESS
de Visser, J. A. G. M., Hermisson, J., Ancel, L. W., Bagheri, H. C., Blanchard, J. L., Chao, L., Cheverud, J. M., Elena, S. F., Gibson, G. C., Hansen, T. F., et al. (2003) · Cited by 98 · see citing works
Burggren, W. W. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.161984 · Cited by 94 · see citing works
“A detailed discussion of this contentious topic is beyond the scope of this Commentary (for discussion, see Debat and David, 2001; Gabriel, 2005; Sommer et al., 2017; Woods, 2014).”
BackgroundQUANTITATIVE GENETICS OF SHAPE IN CRICKET WINGS: DEVELOPMENTAL INTEGRATION IN A FUNCTIONAL STRUCTURE
Klingenberg, C. P., Debat, V., & Roff, D. A. (2010) · Evolution · doi:10.1111/j.1558-5646.2010.01030.x · Cited by 95 · see citing works
“It is not clear how these patterns, as well as the agreement or discrepancies among them, relate to the underlying processes of developmental buffering (i.e., canalization and developmental stability; Debat et al. 2000, 2008, 2009; Debat and David 2001; Breuker et al. 2006b).”
BackgroundSelf-citationHsp90 and the quantitative variation of wing shape in Drosophila melanogaster.
Debat, V., Milton, C. C., Rutherford, S., Klingenberg, C. P., & Hoffmann, A. A. (2006) · PubMed · Cited by 95 · see citing works
Self-citationGenetics of microenvironmental canalization in Arabidopsis thaliana
Hall, M. C., Dworkin, I. M., Ungerer, M. C., & Purugganan, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701936104 · Cited by 92 · see citing works
Oostra, V., de Jong, M. A., Invergo, B. M., Kesbeke, F., Wende, F., Brakefield, P. M., & Zwaan, B. J. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.1560 · Cited by 92 · see citing works
How to Explore Morphological Integration in Human Evolution and Development?
Mitterœcker, P., Gunz, P., Neubauer, S., & Müller, G. B. (2012) · Evolutionary Biology · doi:10.1007/s11692-012-9178-3 · Cited by 91 · see citing works
“Such a process of variance reduction during growth has been termed targeted growth or developmental canalization (e.g., Waddington 1942; Tanner 1963; Debat and David 2001).”
BackgroundLevis, N. A., & Pfennig, D. W. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.01.012 · Cited by 90 · see citing works
Evolution of Morphological Integration: Developmental Accommodation of Stress-Induced Variation
Badyaev, A. V., Foresman, K. R., & Young, R. L. (2005) · The American Naturalist · doi:10.1086/432559 · Cited by 90 · see citing works
“…and S. vagrans) and by comparison with those previously described in exploratory analysis of all four species under this study and with closely related species (Ärnbäck-Christie-Linde 1907; Gaughran 1954; Fearnhead et al. 1955; Sharma 1958; Dötsch 1985, 1986; Badyaev and Foresman 2000).”
BackgroundEffects of small Hsp genes on developmental stability and microenvironmental canalization
Takahashi, K. H., Rako, L., Takano‐Shimizu, T., Hoffmann, A. A., & Lee, S. F. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-284 · Cited by 88 · see citing works
“Debat V, David P: Mapping phenotypes: canalization, plasticity and developmental stability.”
BackgroundDevelopmental and Ecological Benefits of the Maternally Transmitted Microbiota in a Dung Beetle
Schwab, D. B., Riggs, H. E., Newton, I. L. G., & Moczek, A. P. (2016) · The American Naturalist · doi:10.1086/688926 · Cited by 88 · see citing works
Phenotypic Switching Resulting From Developmental Plasticity: Fixed or Reversible?
Burggren, W. W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01634 · Cited by 86 · see citing works
Why and how the early-life environment affects development of coping behaviours
Langenhof, M. R., & Komdeur, J. (2018) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-018-2452-3 · Cited by 90 · see citing works
“The extent to which a (behavioural) trait is plastic or canalised depends on the species, although canalisation is often found more strongly in behaviours that are essential to survival, where there is very little margin for error (Debat and David 2001).”
BackgroundBiological invasion: The influence of the hidden side of the (epi)genome
Marin, P., Genitoni, J., Barloy, D., Maury, S., Gibert, P., Ghalambor, C. K., & Vieira, C. P. (2019) · Functional Ecology · doi:10.1111/1365-2435.13317 · Cited by 86 · see citing works
“These challenges are part of the larger debate and problem of mapping genotypes to phenotypes (Debat & David, 2001; Wagner & Altenberg, 1996).”
BackgroundPhenotypic plasticity and population viability: the importance of environmental predictability
Reed, T. E., Waples, R. S., Schindler, D. E., Hard, J. J., & Kinnison, M. T. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.0771 · Cited by 86 · see citing works
“Environmental canalization, in contrast, occurs when genetic expression is insensitive to the environment—the same phenotype is produced regardless of environmental variation (Debat & David 2001).”
Franssen, N. R., Stewart, L. K., & Schaefer, J. F. (2013) · Ecology and Evolution · doi:10.1002/ece3.842 · Cited by 86 · see citing works
“Observed phenotypic shifts in reservoir habitats are potentially due to phenotypic plasticity as environmentally induced variation is widespread (Schlichting and Pigliucci 1998; West-Eberhard 2003).”
BackgroundHua, J., Morehouse, N. I., & Relyea, R. A. (2013) · Evolutionary Applications · doi:10.1111/eva.12083 · Cited by 86 · see citing works
“…hatched tadpoles, (iv) populations located far from agricultural fields will exhibit greater induced tolerance than populations located close to agricultural fields, (v) tadpoles with induced tolerance will have higher AChE concentrations compared with noninduced tadpoles from the same population.”
BackgroundHormonally mediated maternal effects shape offspring survival potential in stressful environments
Gagliano, M., & McCormick, M. I. (2009) · Oecologia · doi:10.1007/s00442-009-1335-8 · Cited by 85 · see citing works
“The mechanisms that regulate the phenotypic stability of any single trait are mostly maintained by the ability of individuals to express diVerent phenotypes under diVerent environmental conditions (plasticity) and buVer slight genetic abnormalities or environmental disturbance (canalization) or any random error arisin…”
BackgroundLazić, M. M., Carretero, M. Á., Crnobrnja‐Isailović, J., & Kaliontzopoulou, A. (2014) · The American Naturalist · doi:10.1086/679011 · Cited by 84 · see citing works
Pulido, F., & Widmer, M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1343.020 · Cited by 84 · see citing works
The fossil record of fish ontogenies: Insights into developmental patterns and processes
Cloutier, R. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.11.004 · Cited by 82 · see citing works
“, canalization, morphological integration, modularty, and plasticity) and developmental instability [34,35].”
Badyaev, A. V., & Foresman, K. R. (2004) · The American Naturalist · doi:10.1086/386551 · Cited by 81 · see citing works
Gérard, M., Michez, D., Debat, V., Fullgrabe, L., Meeus, I., Piot, N., Sculfort, O., Vastrade, M., Smagghe, G. J., & Vanderplanck, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-33429-4 · Cited by 80 · see citing works
Self-citationPlasticity‐led evolution: A survey of developmental mechanisms and empirical tests
Levis, N. A., & Pfennig, D. W. (2019) · Evolution & Development · doi:10.1111/ede.12309 · Cited by 81 · see citing works
“…as hormonal regulation, epigenetic change, and gene expression in the context of gene regulatory networks (Pfennig & Ehrenreich, 2014) could elucidate the developmental changes that facilitate the transition from environmental induction to canalization (Debat & David, 2001; Debat et al., 2009).”
Arnold, S. J., & Peterson, C. R. (2002) · The American Naturalist · doi:10.1086/341522 · Cited by 80 · see citing works
Ahnesjö, J., & Forsman, A. (2003) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2003.00610.x · Cited by 80 · see citing works
“The insensitivity of body size to temperature conditions experienced during development, together with the covariance between colour morph and body size, suggests that selection has promoted morph-specific canalization of size against environmental perturbations (Weinig, 2000; Debat & David, 2001 ).”
BackgroundInfluentialCareau, V., Buttemer, W. A., & Buchanan, K. L. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu095 · Cited by 79 · see citing works
“An emphasis on R, VI, and Ve connects the study of developmental stress with the key quantitativegenetics concepts of phenotypic plasticity and canalization (Debat and David 2001).”
BackgroundGaubert, P., Wozencraft, W. C., Pinto, P. C. E. D. A., & Veron, G. (2005) · Systematic Biology · doi:10.1080/10635150500232769 · Cited by 75 · see citing works
“A developmental perspective to this hypothesis is that independent acquisition of presumably nonadaptive characters may be due to recurrent processes of canalization (Zakharov, 1992; Debat and David, 2001).”
BackgroundEVOLUTION OF VARIATION AND VARIABILITY UNDER FLUCTUATING, STABILIZING, AND DISRUPTIVE SELECTION
Pélabon, C., Hansen, T. F., Carter, A. J. R., & Houle, D. (2010) · Evolution · doi:10.1111/j.1558-5646.2010.00979.x · Cited by 73 · see citing works
Dworkin, I. (2005) · Evolution; international journal of organic evolution · doi:10.1111/j.0014-3820.2005.tb01799.x · Cited by 78 · see citing works
Canalization, Cryptic Variation, and Developmental Buffering
Dworkin, I. M. (2005) · Elsevier eBooks · doi:10.1016/b978-012088777-4/50010-7 · Cited by 72 · see citing works
“…levels of within-line variation are better canalized than other lines, even though all traits were measured in a single environment (even though this is far from the traditional definition of canalization and has been given other names; see Debat and David, 2001, for a review of these definitions).”
BackgroundMulder, H., Rönnegård, L., Fikse, W., Veerkamp, R., & Strandberg, E. (2013) · Genetics Selection Evolution · doi:10.1186/1297-9686-45-23 · Cited by 69 · see citing works
“selection for reduced variance [14-16].”
Individual Differences in Developmental Plasticity May Result From Stochastic Sampling
Frankenhuis, W., & Panchanathan, K. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611412602 · Cited by 80 · see citing works
“At one extreme, cues may be relatively uninformative, in which case natural selection may favor specialization with minimal sampling, or no sampling at all (Debat & David, 2001).”
BackgroundOn the problem of ratio of anadromy and residence in salmonids (Salmonidae)
Pavlov, D. S., & Savvaitova, K. A. (2008) · Journal of Ichthyology · doi:10.1134/s0032945208090099 · Cited by 67 · see citing works
Environmental and Genetic Influences on Stock Identification Characters
Swain, D. P., Hutchings, J. A., & Foote, C. J. (2005) · Elsevier eBooks · doi:10.1016/b978-012154351-8/50005-8 · Cited by 67 · see citing works
Developmental mechanisms underlying variable, invariant and plastic phenotypes
Abley, K., Locke, J. C. W., & Leyser, O. (2016) · Annals of Botany · doi:10.1093/aob/mcw016 · Cited by 64 · see citing works
Variability in seeds: biological, ecological, and agricultural implications
Mitchell, J., Johnston, I. G., & Bassel, G. W. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw397 · Cited by 65 · see citing works
Comparing Covariance Matrices by Relative Eigenanalysis, with Applications to Organismal Biology
Bookstein, F. L., & Mitterœcker, P. (2013) · Evolutionary Biology · doi:10.1007/s11692-013-9260-5 · Cited by 64 · see citing works
“…kinds of selection and other population processes (see, among others, Tanner 1963; Lande 1979; Philipps and Arnold 1989; Gibson and Wagner 2000; Debat and David 2001; Hallgrimsson et al. 2002; Badyaev and Foresman 2004; Hallgrimsson and Hall 2005; Mitteroecker 2009; Mitteroecker et al. 2012).”
BackgroundInfluentialThe integrative biology of genetic dominance
Billiard, S., Castric, V., & Llaurens, V. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12786 · Cited by 64 · see citing works
Sanchez, S., & Schoch, R. R. (2013) · Evolutionary Biology · doi:10.1007/s11692-013-9238-3 · Cited by 65 · see citing works
“The current observations of concomitant histological plasticity and morphological consistency within a single taxon would support the concept of ‘canalization’ first proposed by Waddington in 1942 (Debat and David 2001; Flatt 2005).”
BackgroundInfluentialRiechert, S. E., & Jones, T. C. (2008) · Animal Behaviour · doi:10.1016/j.anbehav.2007.10.033 · Cited by 63 · see citing works
“Several lines of evidence support the view that social behaviour in A. studiosus is, indeed, canalized in the sense that the behaviour of individuals is resistant to environmentally induced change (see review of plasticity and canalization by Debat & David 2001).”
- Authors
- Debat, V., & David, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Trends in Ecology & Evolution
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 16
- Issue
- 10
- Pages
- 555-561
- ISSN
- 0169-5347 (ISSN-L)
- OpenAlex
- W2138673359
- Cited by
- 614
- References
- 51
- Citations by year
- 2026: 34 · 2025: 20 · 2024: 27 · 2023: 16 · 2022: 21 · 2021: 34 · 2020: 36 · 2019: 35 · 2018: 39 · 2017: 30 · 2016: 34 · 2015: 33 · 2014: 24 · 2013: 26 · 2012: 29
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Ecology & Evolution (publishedVersion)
- HAL (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- canalization, phenotypic plasticity, developmental stability, genotype-phenotype correlation, phenotypic variability, phenotypic evolution, natural selection, molecular genetics, developmental genetics
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