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Cited by 184Stress Responses and CortisolPosttraumatic Stress Disorder ResearchNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 151 of the 152 references it cites were found in a registry or an index.

The neurobiology and neuroendocrinology of stress

McEwen, Bruce S·2002·Psychiatric Clinics of North America
DOI 10.1016/s0193-953x(01)00009-0
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Abstract

Stress is a condition of the mind and a factor in the expression of disease that differs among individuals. In post-traumatic stress disorder (PTSD), traumatic events can create a long-lasting state of physiologic reactivity that amplifies and exacerbates the effects of daily life events. The elevated activities of physiologic systems lead to wear and tear, called "allostatic load." It reflects not only the impact of life experiences but also of genes, individual life-style habits (e.g., diet, exercise, and substance abuse), and developmental experiences that set life-long patterns of behavior and physiologic reactivity. Hormones associated with stress and allostatic load protect the body in the short run and promote adaptation, but in the long run allostatic load causes changes in the body that lead to disease.

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Citations

Cites

Show all 152 references

Research works printed but not linked: 14

  1. McKittrick, 1996, Chronic social stress decreases binding to 5HT transporter sites and reduces dendritic arbors in CA3 of hippocampus, Abstract, Soc Neurosci, 22
  2. Weiland, 1995, Corticosterone regulates mRNA levels of specific subunits of the NMDA receptor in the hippocampus but not in cortex of rats, Soc Neurosci, 21, 502
  3. Tanapat, 1997, EGF stimulates proliferation of granule cell precursors in the dentate gyrus of adult rats, Soc Neurosci, 23, 317
  4. Fallah, 1998, Hippocampal neurogenesis in old world primates declines with aging, Soc Neurosci, 24, 1993
  5. McEwen, 1992, Re-examination of the glucocorticoid cascade hypothesis of stress and aging, vol. 93, 365
  6. Radley, 1998, Blockade of 5HT1A receptors prevents hippocampal granule cell genesis during and after pilocarpine-induced status epilepticus, Soc Neurosci, 24, 1992
  7. Galea, 1996, Exposure to predator odor suppresses cell proliferation in the dentate gyrus of adult rats via a cholinergic mechanism, Soc Neurosci, 22, 1196
  8. Pham, 1999, Chronic restraint stress suppresses proliferation of neural precursors in the dentate gyrus but not survival of granule cells, Abstr Soc Neurosci, 25, 255
  9. Lupien, 1996, Longitudinal increase in cortisol during human aging predicts hippocampal atrophy and memory deficits, Soc Neurosci, 22, 1889
  10. Ongur, 1998, Glial loss in the subgenual prefrontal cortex in familial mood disorders, Soc Neurosci, 24, 990
  11. Kaufman, 1999, Neurobiological correlates of child abuse, Biol Psychiatry, 45, 1235
  12. DeBellis, 1999, Developmental traumatology, Biol Psychiatry, 45, 1259
  13. Wood, 2000, Chronic restraint stress increases aggression in male rats, Soc Neurosci, 26, 547
  14. Chattarji, 2000, Effects of chronic unpredictable and immobilization stress on neuronal plasticity in the rat amygdala and hippocampus, Soc Neurosci, 26, 1533

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Metadata

Authors
McEwen, B. S.
Affiliations
Rockefeller University (US)
Corresponding author
McEwen, Bruce S
ORCID
McEwen, Bruce S
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2002-06
Volume
25
Issue
2
Pages
469-494
ISSN
0193-953X (ISSN-L)
DOI
10.1016/s0193-953x(01)00009-0
OpenAlex
W2165374000
Cited by
184
References
152
Citations by year
2025: 4 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 9 · 2012: 4
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
stress, neurobiology of stress, neuroendocrinology, post-traumatic stress disorder, allostatic load, stress hormones, physiological reactivity, individual differences, disease susceptibility, developmental experiences, lifestyle factors
MeSH terms
Aging, Animals, Brain, Hippocampus, Homeostasis, Humans, Neurosecretory Systems, Stress, Physiological, Stress Disorders, Post-Traumatic, Neurotransmitter Agents, Models, Animal

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