Cited by 184Stress Responses and CortisolPosttraumatic Stress Disorder ResearchNeuropeptides and Animal Physiology

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The neurobiology and neuroendocrinology of stress

McEwen, Bruce S·2002·Psychiatric Clinics of North America

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Abstract

Stress is a condition of the mind and a factor in the expression of disease that differs among individuals. In post-traumatic stress disorder (PTSD), traumatic events can create a long-lasting state of physiologic reactivity that amplifies and exacerbates the effects of daily life events. The elevated activities of physiologic systems lead to wear and tear, called "allostatic load." It reflects not only the impact of life experiences but also of genes, individual life-style habits (e.g., diet, exercise, and substance abuse), and developmental experiences that set life-long patterns of behavior and physiologic reactivity. Hormones associated with stress and allostatic load protect the body in the short run and promote adaptation, but in the long run allostatic load causes changes in the body that lead to disease.

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McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Self-citation
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,478
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614

Show all 152 references

Research works printed but not linked: 14

McKittrick, 1996, Chronic social stress decreases binding to 5HT transporter sites and reduces dendritic arbors in CA3 of hippocampus, Abstract, Soc Neurosci, 22
Weiland, 1995, Corticosterone regulates mRNA levels of specific subunits of the NMDA receptor in the hippocampus but not in cortex of rats, Soc Neurosci, 21, 502
Tanapat, 1997, EGF stimulates proliferation of granule cell precursors in the dentate gyrus of adult rats, Soc Neurosci, 23, 317
Fallah, 1998, Hippocampal neurogenesis in old world primates declines with aging, Soc Neurosci, 24, 1993
McEwen, 1992, Re-examination of the glucocorticoid cascade hypothesis of stress and aging, vol. 93, 365
Radley, 1998, Blockade of 5HT1A receptors prevents hippocampal granule cell genesis during and after pilocarpine-induced status epilepticus, Soc Neurosci, 24, 1992
Galea, 1996, Exposure to predator odor suppresses cell proliferation in the dentate gyrus of adult rats via a cholinergic mechanism, Soc Neurosci, 22, 1196
Pham, 1999, Chronic restraint stress suppresses proliferation of neural precursors in the dentate gyrus but not survival of granule cells, Abstr Soc Neurosci, 25, 255
Lupien, 1996, Longitudinal increase in cortisol during human aging predicts hippocampal atrophy and memory deficits, Soc Neurosci, 22, 1889
Ongur, 1998, Glial loss in the subgenual prefrontal cortex in familial mood disorders, Soc Neurosci, 24, 990
Kaufman, 1999, Neurobiological correlates of child abuse, Biol Psychiatry, 45, 1235
DeBellis, 1999, Developmental traumatology, Biol Psychiatry, 45, 1259
Wood, 2000, Chronic restraint stress increases aggression in male rats, Soc Neurosci, 26, 547
Chattarji, 2000, Effects of chronic unpredictable and immobilization stress on neuronal plasticity in the rat amygdala and hippocampus, Soc Neurosci, 26, 1533

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Glover, D. A., Powers, M. B., Bergman, L., Smits, J. A. J., Telch, M. J., & Stuber, M. L. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00074-3 · Cited by 44
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Desai, D. C., O’Dorisio, T. M., Schirmer, W. J., Jung, S. S., Khabiri, H., Villanueva, V., & Martin, E. W. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00167-1 · Cited by 40
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Cohen, H., Matar, M., & Zohar, J. (2014) · ILAR Journal · doi:10.1093/ilar/ilu006 · Cited by 37
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Authors: McEwen, B. S.
Affiliations: Rockefeller University (US)
Corresponding author: McEwen, Bruce S
ORCID: McEwen, Bruce S
Venue: Psychiatric Clinics of North America
Publisher: Elsevier BV
Published: 2002-06
Volume: 25
Issue: 2
Pages: 469-494
ISSN: 0193-953X (ISSN-L)
DOI: 10.1016/s0193-953x(01)00009-0
OpenAlex: W2165374000
Cited by: 184
References: 152
Citations by year: 2025: 4 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 9 · 2012: 4
FWCI: 0.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatric Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: stress, neurobiology of stress, neuroendocrinology, post-traumatic stress disorder, allostatic load, stress hormones, physiological reactivity, individual differences, disease susceptibility, developmental experiences, lifestyle factors
MeSH terms: Aging, Animals, Brain, Hippocampus, Homeostasis, Humans, Neurosecretory Systems, Stress, Physiological, Stress Disorders, Post-Traumatic, Neurotransmitter Agents, Models, Animal

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