The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus
Abstract
The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.
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In the citing paper
“There are differences in orexin neuron populations between males and females.”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [108]
In the citing paper
“There is more of the precursor mRNA to orexin, prepro-orexin, in female animals,108 and higher levels of orexin in females.109”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [108]
Citations
Cites
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
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Neurons containing hypocretin (orexin) project to multiple neuronal systems
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Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
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Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions
Higuchi, R., Fockler, C., Dollinger, G. D., & Watson, R. H. (1993) · Nature Biotechnology · doi:10.1038/nbt0993-1026 · Cited by 2,205
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Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401
Research works printed but not linked: 1
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Items 101–112 of 112
Schuller, J., & Koch, M. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114268 · Cited by 1
Hypocretin modulation of behavioral coping strategies for social stress
Luo, P. X., & Trainor, B. C. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.031 · Cited by 1
Nagel, J. D. (2014) · Journal of Women s Health · doi:10.1089/jwh.2014.ab05.abstracts
Nagel, J. D., & Rudick, J. E. (2011) · Journal of Women s Health · doi:10.1089/jwh.2011.ab02
Orexin Drives Energy Expenditure
Perez‐Leighton, C. E., Teske, J. A., & Kotz, C. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813751-2.00003-6
Role of Sex and Orexin in Sleep Disruption Induced Weight Gain
Coborn, J. E. (2018) · UA Campus Repository (The University of Arizona)
Fanselow, M. S., & Rajbhandari, A. K. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733583795.793560179
Neuroendocrine Regulation of Anxiety
Onisiforou, A., Zanos, P., & Georgiou, P. (2024) · Springer eBooks · doi:10.1007/978-3-031-56798-8_3
Les hypersomnies centrales chez la femme
Peter‐Derex, L., Auffret, M., Lambert, I., Atzenhoffer, M., Rousset‐Jablonski, C., & Arnulf, I. (2026) · Médecine du Sommeil · doi:10.1016/j.msom.2026.03.001
Formalin-induced pain preferentially activates orexin neurons in male mice
Fukasawa, S., Mukae, S., Matsuo, A., & Kanaya, M. (2026) · Neuroscience Letters · doi:10.1016/j.neulet.2026.138620
Sex- and gender-related differences in narcolepsy and idiopathic hypersomnia: a narrative review
Chung, J. S., Tao, G., Lin, A., Tai, J. E., Garden, G., D'Rozario, A. L., Cayanan, E. A., Schokman, A., Chadwick, M., Grunstein, R., et al. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102386
Metadata
- Authors
- Jöhren, O., Neidert, S. J., Kummer, M., & Dominiak, P.
- Affiliations
- University of Lübeck (DE)
- Corresponding author
- Jöhren, Olaf
- ORCID
- Jöhren, Olaf
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 23
- Issue
- 6
- Pages
- 1177-1180
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2013679503
- Cited by
- 112
- References
- 33
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- orexin, sex differences, hypothalamus, lateral hypothalamus, orexin-A, orexin B, energy homeostasis, arousal
- MeSH terms
- Orexins, Animals, Electrophoresis, Agar Gel, Female, Gene Expression Regulation, Hypothalamus, Male, Neuropeptides, Plasmids, Protein Precursors, RNA, Messenger, Sex Factors, Rats, Wistar, DNA, Complementary, Reverse Transcriptase Polymerase Chain Reaction, Intracellular Signaling Peptides and Proteins, Rats
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