The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus
Abstract
The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.
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In the citing paper
“There are differences in orexin neuron populations between males and females.”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [108]
In the citing paper
“There is more of the precursor mRNA to orexin, prepro-orexin, in female animals,108 and higher levels of orexin in females.109”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [108]
Citations
Cites
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions
Higuchi, R., Fockler, C., Dollinger, G. D., & Watson, R. H. (1993) · Nature Biotechnology · doi:10.1038/nbt0993-1026 · Cited by 2,205
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401
Research works printed but not linked: 1
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Cited by
Sorted by citations
Sex differences in stress reactivity in arousal and attention systems
Bangasser, D. A., Eck, S. R., & Sanchez, E. O. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0137-2 · Cited by 192
The Hypothalamic Orexinergic System: Pain and Primary Headaches
Holland, P. R., & Goadsby, P. J. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.00842.x · Cited by 181
Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility
Grafe, L. A., Cornfeld, A., Luz, S., Valentino, R., & Bhatnagar, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.013 · Cited by 135
Grafe, L. A., & Bhatnagar, S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.003 · Cited by 136
de Rijke, C. E., Hillebrand, J. J., Verhagen, L. A. W., Roeling, T. A. P., & Adan, R. A. H. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01808 · Cited by 126
Metadata
- Authors
- Jöhren, O., Neidert, S. J., Kummer, M., & Dominiak, P.
- Affiliations
- University of Lübeck (DE)
- Corresponding author
- Jöhren, Olaf
- ORCID
- Jöhren, Olaf
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 23
- Issue
- 6
- Pages
- 1177-1180
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2013679503
- Cited by
- 112
- References
- 33
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- orexin, sex differences, hypothalamus, lateral hypothalamus, orexin-A, orexin B, energy homeostasis, arousal
- MeSH terms
- Orexins, Animals, Electrophoresis, Agar Gel, Female, Gene Expression Regulation, Hypothalamus, Male, Neuropeptides, Plasmids, Protein Precursors, RNA, Messenger, Sex Factors, Rats, Wistar, DNA, Complementary, Reverse Transcriptase Polymerase Chain Reaction, Intracellular Signaling Peptides and Proteins, Rats
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