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Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus
Abstract
The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins.
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“There are differences in orexin neuron populations between males and females.”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [108]
In the citing paper
“There is more of the precursor mRNA to orexin, prepro-orexin, in female animals,108 and higher levels of orexin in females.109”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [108]
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Metadata
- Authors
- Jöhren, O., Neidert, S. J., Kummer, M., & Dominiak, P.
- Affiliations
- University of Lübeck (DE)
- Corresponding author
- Jöhren, Olaf
- ORCID
- Jöhren, Olaf
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 23
- Issue
- 6
- Pages
- 1177-1180
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2013679503
- Cited by
- 112
- References
- 33
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- orexin, sex differences, hypothalamus, lateral hypothalamus, orexin-A, orexin B, energy homeostasis, arousal
- MeSH terms
- Orexins, Animals, Electrophoresis, Agar Gel, Female, Gene Expression Regulation, Hypothalamus, Male, Neuropeptides, Plasmids, Protein Precursors, RNA, Messenger, Sex Factors, Rats, Wistar, DNA, Complementary, Reverse Transcriptase Polymerase Chain Reaction, Intracellular Signaling Peptides and Proteins, Rats
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