The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Effects of orexin-A on memory processing
Abstract
Orexin-A is an endogenous peptide with receptors present throughout the brain. Here, we examined the effect of post-training administration of orexin-A on retention in active and passive avoidance. Orexin-A administered by intracerebroventricular (i.c.v.) injection to CD-1 mice post-training improved retention in both T-maze footshock avoidance and one trial step-down passive avoidance. SAMP8 mice have age-related deficits in learning and memory, which correlate with an increase in brain levels of beta amyloid (Abeta) and an impaired response to memory-enhancing compounds. Orexin-A at 3nmol improved retention in young and old SAMP8 mice. These findings show that orexin-A can improve memory even with overproduction of Abeta.
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“Orexin is also associated with memory processing,113–116 motivation, reward,117 and addiction,118 which have been described as behaviors that are affected by TBI.9,119–123”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [114]
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Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401
Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268
Distribution of orexin neurons in the adult rat brain
Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M., & Goto, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01336-0 · Cited by 1,070
Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050
Arousal effect of orexin A depends on activation of the histaminergic system
Huang, Z., Qu, W., Li, W., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y., & Hayaishi, O. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181330998 · Cited by 555
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Martinez, J. L., Thompson, K. J., Leussis, M. P., & Heinrichs, S. C. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7867-8_9 · Cited by 2
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Neuroprotective activity of orexin system in ischemic stroke
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Luis, J., Alberto, C., Barrachina, M., Ferrer, I., & Marti, M. (2011) · InTech eBooks · doi:10.5772/17842
Dhuria, S. V. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
The Aminergic Systems and the Hypocretins
Selbach, O., & Haas, H. L. (2005) · Springer eBooks · doi:10.1007/0-387-25446-3_11
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Novel pathways for stimulant development II: the hypocretin/orexin system
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Sebastiano, D., & Andrea, R. C. (2012) · Scholarship@Western (Western University)
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Small molecule orexin agonist ROXA-47 enhances learning and memory in mice
Mavanji, V., Zhang, D., Decker, A. M., Zhang, Y., & Kotz, C. M. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174246
Metadata
- Authors
- Jaeger, L. B., Farr, S. A., Banks, W. A., & Morley, J. E.
- Affiliations
- St. Louis VA Medical Center (US)
- Corresponding author
- Farr, Susan A
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 23
- Issue
- 9
- Pages
- 1683-1688
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2068523799
- Cited by
- 116
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 8
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- orexin-A, memory consolidation, avoidance learning, passive avoidance, active avoidance, SAMP8 mice, age-related memory impairment, amyloid-beta, memory enhancement, intracerebroventricular administration
- MeSH terms
- Orexins, Animals, Avoidance Learning, Brain, Carrier Proteins, Dose-Response Relationship, Drug, Male, Memory, Neuropeptides, Time Factors, Amyloid beta-Peptides, Maze Learning, Intracellular Signaling Peptides and Proteins, Mice
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