The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The CERAD Neuropathology Protocol and Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease: A Commentary
Abstract
CERAD, a multicenter longitudinal study, has developed standardized instruments for the evaluation of individuals clinically diagnosed as having Alzheimer's disease (AD). The CERAD neuropathology protocol not only establishes levels of certainty for AD diagnosis, but also records information on other conditions occurring concomitantly with or misdiagnosed as AD. The protocol has been widely adopted because of its relative simplicity, adaptability, and reliability. Indeed, the Consensus principles proposed are, for the most part, consistent with CERAD guidelines. The recommendation that diagnosis rest upon both neuritic plaque and neurofibrillary tangle frequency/distribution in the neocortex, however, is worrisome. This change will eliminate or downgrade many cases now diagnosed as AD with concomitant Parkinson's disease changes. Reclassifying such cases at this time, without compelling pathobiological justification, is premature. Instead, I recommend retention or modest modification of the current CERAD protocol, and propose that neuropathology data available on autopsies of over 200 CERAD dementia subjects be used for testing potential modifications of the diagnostic algorithm.
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“A particularly important subtype of AβPs are “neuritic plaques” (NPs), as they are more likely to be associated with cognitive impairment than “diffuse plaques” (49-51).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [51]
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Self-citationMoms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
Self-citationConsortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Progressive Supranuclear Palsy
Steele, J. C. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460160003001 · Cited by 1,930
Tierney, M. C., Fisher, R. H., Lewis, A. J., Zorzitto, M. L., Snow, W. G., Reid, D. W., & Nieuwstraten, P. (1988) · Neurology · doi:10.1212/wnl.38.3.359 · Cited by 613
Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996) · Neurology · doi:10.1212/wnl.46.6.1592 · Cited by 561
Self-citationMaking the diagnosis of Alzheimer's disease. A primer for practicing pathologists.
Mirra, S. S., Hart, M. N., & Terry, R. D. (1993) · PubMed · Cited by 412
Self-citation
Research works printed but not linked: 2
- Mirra, 1993, Making the diagnosis of Alzheimer’s disease, Arch. Pathol. Lab. Med., 117, 132
- Nagy, 1995, Relative roles of plaques and tangles in the dementia of Alzheimer’s disease, Dementia, 6, 21
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Items 201–236 of 236
Neuropathology of Feline Dementia
Head, E., & Gunn-Moore, D. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-53219-6_6 · Cited by 7
Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein AbundancePreprint
Collins, M. A., Friedrich, C., Elcheikhali, M., Stewart, P., Derks, J., Connors, T. R., Altig, K., Melloni, A. N., Petelski, A. A., Oakley, D. H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656728 · Cited by 5
Characterization of Isolated Human Astrocytes from Aging Brain
Serrano, G. E., Aslam, S., Walker, J. E., Piras, I. S., Huentelman, M. J., Arce, R. A., Glass, M. J., Intorcia, A. J., Suszczewicz, K. E., Borja, C. I., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073416 · Cited by 3
Subjective Sleep Disturbance and Lewy Pathology: Data from a Cohort of Essential Tremor Brain Donors
Ghanem, A., Berry, D. S., Cosentino, S., Faust, P. L., & Louis, E. D. (2024) · Neurodegenerative Diseases · doi:10.1159/000539032 · Cited by 3
Louis, E. D., Hernandez, N. C., Guy, T., & Faust, P. L. (2025) · Annals of Neurology · doi:10.1002/ana.27302 · Cited by 2
Musacchio, J. B., Martuscello, R. T., Betzios, S. I., Hernandez, R. S., Kuo, S., Cosentino, S., Fujita, H., Louis, E. D., & Faust, P. L. (2026) · Acta Neuropathologica · doi:10.1007/s00401-025-02974-4 · Cited by 2
The Dog as a Model for Aging Research
Jones, A., Head, E., & Greer, K. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00014-2 · Cited by 2
Morelli, L., Perry, G. L., & Tagliavini, F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/709613 · Cited by 2
Dependence Clusters in Alzheimer Disease and Medicare Expenditures
Zhu, C. W., Lee, S., Ornstein, K. A., Cosentino, S., Gu, Y., Andrews, H., & Stern, Y. (2020) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000402 · Cited by 2
A Pragmatic Approach to the Postmortem Neuropathological Diagnosis of Dementia
Reichard, R. R., & Parisi, J. E. (2012) · Academic Forensic Pathology · doi:10.23907/2012.001 · Cited by 2
Knopman, D. S., Ritchie, K. A., Polge, C., Alafuzoff, I. I., & Soininen, H. S. (2003) · Wiley eBooks · doi:10.1002/9780470752340.ch19 · Cited by 2
Introduction to Basic Neuropathology
Yachnis, A. T. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5226-2_6 · Cited by 1
Aguillon, D. F., Vásquez, D., Madrigal, L., Moreno, S., Hernández, D. L., Isaza-Ruget, M. A., Rivera, J. J. L., Landires, I., Núñez-Samudio, V., Restrepo, C. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02821-7 · Cited by 1
Spoken discourse in Alzheimer' disease: a review
Ahmed, S., & Garrard, P. (2012) · Linguistica · doi:10.4312/linguistica.52.1.9-25 · Cited by 3
Ancestralidade da população de São Paulo e correlação com alterações neuropatológicas no idoso
Schlesinger, D. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2010.tde-17122010-142628 · Cited by 1
Neltner, J. H., & Nelson, P. T. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch1 · Cited by 1
Richardson, E. E. (2011) · Human Biology
Maladie d'Alzheimer et maladies apparentées – approches de la fin de vie
Hournau-Blanc, J. (2014) · Jusqu’à la mort accompagner la vie · doi:10.3917/jalmalv.117.0091 · Cited by 2
Ma, K., Babij, R., Vonsattel, J., & Louis, E. D. (2012)
Morrison, J. (2015) · UWSpace (University of Waterloo)
Targeting Mitochondria for Healthy Brain Aging
Yonutas, H. M., Head, E., & Sullivan, P. G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418680-4.00008-7
Kalaria, R. N. (2005) · CRC Press eBooks · doi:10.1201/b13239-82
Naslavsky, M. S. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2016.tde-14012016-092908
CANINE COGNITIVE DISFUNCTION SYNDROME
Dimzas, D., Papaioannou, N., & Tsolaki, M. (2018) · ВЕТЕРИНАРСКИ ЖУРНАЛ РЕПУБЛИКЕ СРПСКЕ · doi:10.7251/vetj1502194d
Occupational exposure to metals and impact on dementia incidence
Motz, P. (2018) · ResearchWorks at the University of Washington (University of Washington)
Aguillon, D. F., Vasquez, D., Madrigal, L., Moreno, S., Hernández, D. L., Isaza-Ruget, M. A., Rivera, J. J. L., Landires, I., Núñez-Samudio, V., Restrepo, C. M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1026107/v1
Widner, J., Faust, P. L., Louis, E. D., & Fujita, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.26.633063
OXIDATIVE DAMAGE TO DNA IN ALZHEIMER'S DISEASE
Soman, S. (2013) · UKnowledge (University of Kentucky)
Vizcarra, J. C., Gearing, M., Keiser, M. J., Glass, J. D., Dugger, B. N., & Gutman, D. A. (2020) · Figshare · doi:10.6084/m9.figshare.12211502
Betzios, S. I., Hernandez, R. S., Faust, P. L., & Louis, E. D. (2026) · The Cerebellum · doi:10.1007/s12311-026-01965-9
Duboisdindien, G. (2019) · theses.fr (ABES) · doi:10.70675/6821648cz8e25z4ee6zb599z489e8dc89766
Psychometric criteria for superior cognitive performance in very old adults
Malek‐Ahmadi, M. H., Perez, S. E., He, B., Rogalski, E. J., Counts, S., Ikonomović, M. D., Abrahamson, E. E., Ginsberg, S. D., Alldred, M. J., Serrano, G. E., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261435166
Price (1999) · doi:10.1002/1531-8249(199903)45:3
Metadata
- Authors
- Mirra, S. S.
- Affiliations
- Emory University (US)
- Corresponding author
- Mirra, S.S
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 18
- Issue
- 4
- Pages
- S91-S94
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2137794576
- Cited by
- 236
- References
- 26
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 5 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 12 · 2014: 15 · 2013: 14 · 2012: 19
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuritic plaques, neurofibrillary tangles, neocortex, diagnostic algorithm
- MeSH terms
- Aged, Algorithms, Alzheimer Disease, Brain, Diagnosis, Differential, Diagnostic Errors, Humans, Longitudinal Studies, Parkinson Disease, Severity of Illness Index, Multicenter Studies as Topic, Neurofibrillary Tangles, Guidelines as Topic, Disease Progression
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