The NINCDS‐ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: A clinicopathologic study of 57 cases
Abstract
Neuropathologic confirmation is required to validate the NINCDS-ADRDA Work Group criteria for the clinical diagnosis of Alzheimer's disease (AD). Neuropathologic inclusion and exclusion criteria for AD, however, are not uniform. The purpose of this investigation was to examine the confirmation rate for the Work Group criteria against differing neuropathologic criteria for AD. The sample consisted of 57 cases, 22 of which had received a clinical diagnosis of AD. Nine neuropathologic criteria for AD were applied in a blind fashion to each of the 57 cases. Our results indicated that, depending on the neuropathologic criteria applied, the clinicopathologic agreement ranged from 64% to 86%. These findings demonstrate the need for universally accepted neuropathologic and clinical criteria for AD.
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There have been several changes in neuropathological diagnostic criteria, including Khachaturian 1985, Tierney 1988, CERAD 1991, NIA-Reagan 1997.
“there have been several changes in neuropathological diagnostic criteria, including the “Khachaturian criteria” of 1985 (27), the “Tierney” criteria of 1988 (28), The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria in 1991 (29), and the National Institute on Aging (NIA)-Reagan criteria in 1997 (30).”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [28]
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- Authors
- Tierney, M. C., Fisher, R. H., Lewis, A. J., Zorzitto, M. L., Snow, W. G., Reid, D. W., & Nieuwstraten, P.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Venue
- Neurology
- Published
- 1988-03
- Volume
- 38
- Issue
- 3
- Pages
- 359-359
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2082665846
- Cited by
- 613
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 17
- FWCI
- 26.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, NINCDS-ADRDA criteria, diagnosis, clinicopathological correlation, diagnostic agreement
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Ischemia, Diagnosis, Differential, Female, Hippocampus, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Parkinson Disease
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