Neuro-inflammation and anti-inflammatory treatment options for Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and dementia. The pathological characteristics of AD include the deposition of amyloid beta (Aβ), neurofibrillary tangles, and neuronal loss. There is evidence showing the involvement of inflammation in AD, including activated microglia within and surrounding senile plaques. Epidemiological studies suggest the use of anti-inflammatory drugs to reduce incidence of AD. However, clinical trials with anti-inflammatory drugs have not been successful.
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In Alzheimer's disease, the increase in soluble Aβ oligomeric species, aggregated Aβ plaques and neurofibrillary tangles of hyperphosphorylated Tau proteins leads to activation of microglia and thus to neuroinflammation.
“In AD, the increase in soluble Aβ oligomeric species, aggregated Aβ plaques and neurofibrillary tangles of hyperphosphorylated Tau proteins leads to activation of microglia and thus to neuroinflammation [79,139,140].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [139]
Cites
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Inflammation as a central mechanism in Alzheimer's disease
Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works
Risk of Alzheimer's disease and duration of NSAID use
Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132 · see citing works
Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
Newcombe, E. A., Camats-Perna, J., Silva, M. L., Valmas, N., Huat, T. J., & Medeiros, R. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1313-3 · Cited by 532 · see citing works
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
ADAPT Research Group (2007) · Neurology · doi:10.1212/01.wnl.0000260269.93245.d2 · Cited by 354 · see citing works
Reduced incidence of AD with NSAID but not H2receptor antagonists
Zandi, P. P., Anthony, J. C., Hayden, K. M., Mehta, K. M., Mayer, L. S., & Breitner, J. C. S. (2002) · Neurology · doi:10.1212/wnl.59.6.880 · Cited by 314 · see citing works
Hu, J., Akama, K. T., Krafft, G. A., Chromy, B. A., & Eldik, L. J. V. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01318-8 · Cited by 313 · see citing works
Advances in developing novel therapeutic strategies for Alzheimer’s disease
Cao, J., Hou, J., Ping, J., & Cai, D. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0299-8 · Cited by 283 · see citing works
Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., & Grubeck-Loebenstein, B. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0321 · Cited by 258 · see citing works
Inflammation, Antiinflammatory Agents, and Alzheimer’s Disease: The Last 22 Years
McGeer, P. L., Rogers, J., & McGeer, E. G. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160488 · Cited by 215 · see citing works
Neuroinflammation, gut microbiome, and Alzheimer's disease
Lin, L., Zheng, L. J., & Zhang, L. J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0983-2 · Cited by 147 · see citing works
NSAIDs and incident Alzheimer’s disease. The Rotterdam study
In ’t Veld, B. A., Launer, L. J., Hoes, A. W., Ott, A., Hofman, A., Breteler, M. M. B., & Stricker, B. H. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00096-7 · Cited by 145 · see citing works
Rheumatold Arthritis and Senile Dementia of the Alzhelmer's Type
Jenkinson, M. L., Bliss, M. R., BRAIN, A. T., & Scott, D. L. (1989) · Lara D. Veeken · doi:10.1093/rheumatology/28.1.86-b · Cited by 143 · see citing works
Genome-wide Association Studies in Alzheimer’s Disease: A Review
Tosto, G., & Reitz, C. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0381-0 · Cited by 124 · see citing works
Szekely, C. A., Green, R. C., Breitner, J. C. S., Østbye, T., Beiser, A. S., Corrada, M. M., Dodge, H. H., Ganguli, M., Kawas, C. H., Kuller, L. H., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000313933.17796.f6 · Cited by 121 · see citing works
In vivo molecular imaging of neuroinflammation in Alzheimer's disease
Chaney, A. M., Williams, S. R., & Boutin, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14615 · Cited by 116 · see citing works
Price, J. F., Stewart, M. C., Deary, I. J., Murray, G. D., Sandercock, P., Butcher, I., Fowkes, F. G. R., & Trialists, O. B. O. T. A. (2008) · BMJ · doi:10.1136/bmj.a1198 · Cited by 96 · see citing works
An Overview of Genome-Wide Association Studies in Alzheimer’s Disease
Shen, L., & Jia, J. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0011-3 · Cited by 90 · see citing works
Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
Yip, A., Green, R., Huyck, M., Cupples, L., & Farrer, L. (2005) · BMC Geriatrics · doi:10.1186/1471-2318-5-2 · Cited by 78 · see citing works
Can inflammation be resolved in Alzheimer’s disease?
Zhu, M., Wang, X., Sun, L., Schultzberg, M., & Hjorth, E. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418791107 · Cited by 62 · see citing works
NSAIDs and Alzheimer’s disease: contribution of observational epidemiologic studies
Launer, L. J., & Veld, B. A. I. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00103-1 · Cited by 8 · see citing works
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Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease
Bai, R., Guo, J., Ye, X.-Y., Xie, Y., & Xie, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101619 · Cited by 813 · see citing works
García-Morales, V., González-Acedo, A., Melguizo-Rodríguez, L., Pardo-Moreno, T., Costela-Ruiz, V. J., Montiel-Troya, M., & Ramos-Rodríguez, J. J. (2021) · Biomedicines · doi:10.3390/biomedicines9121910 · Cited by 104 · see citing works
Beneficial Effects of Spirulina Consumption on Brain Health
Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98 · see citing works
Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease
Aili, M., Zhou, K., Zhan, J., Zheng, H., & Luo, F. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01023f · Cited by 80 · see citing works
Bridging neurotrophic factors and bioactive peptides to Alzheimer’s disease
Wei, M., Wu, T., & Chen, N. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102177 · Cited by 31 · see citing works
Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease
Li, Z., Gan, L., Yan, S., Yan, Y., & Huang, W. (2020) · Translational Neuroscience · doi:10.1515/tnsci-2020-0101 · Cited by 23 · see citing works
Retracted
- Authors
- Ozben, T., & Ozben, S.
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 72
- Pages
- 87-89
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W2934170679
- Cited by
- 381
- References
- 21
- Citations by year
- 2026: 21 · 2025: 66 · 2024: 75 · 2023: 88 · 2022: 64 · 2021: 38 · 2020: 26 · 2019: 3
- FWCI
- 22.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, neuroinflammation, anti-inflammatory agents, amyloid-beta, neurofibrillary tangles, microglia, amyloid plaques, neurodegeneration, dementia, clinical trial failure
- MeSH terms
- Alzheimer Disease, Anti-Inflammatory Agents, Non-Steroidal, Humans, Inflammation
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