Malignant tumors arising in endometriosis: Clinical-pathological study and flow cytometry analysis
Abstract
Background Malignant transformation to endometriosis is a well documented phenomenon that occurs most commonly in the ovaries with cancer arising in extra-ovarian endometriosis being a rare event.Methods A retrospective clinical-pathological evaluation of eleven cases with malignant tumors arising in endometriosis was performed to evaluate the prognostic impact of various factors. Nuclear DNA content (ploidy) was assessed through flow cytometric study.Results Ovarian origin was identified in eight cases and three were associated with extra-ovarian endometriosis. Histologic type was endometrioid carcinoma in ten patients. The eleventh case had high grade endometrial stromal sarcoma. All tumors were diploid with no relation to stage, grade, or clinical outcome. The S-phase fraction (SPF) was analyzed in nine patients and no correlation could be demonstrated with any histologic parameters or clinical outcome.Conclusions The DNA content seems to have no association with the classical prognostic parameters in these cases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Various histological types of malignancy have been reported regarding extraovarian endometriosis: endometrioid stromal sarcoma, adenosarcoma, and carcinosarcoma.
“Moreover, various histological types of malignancy have been reported regarding extraovarian endometriosis: endometrioid stromal sarcoma, adenosarcoma, and carcinosarcoma [21].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [21]
Out of five ESS cases in peritoneum/deep endometriosis, two high-grade ESS patients died of disease at 6 and 24 months.
“Out of the five ESS cases, two cases were high-grade ESS who died of disease (6 months [82] and 24 months [21]).”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [21]
Cites
Firminger, H. I. (1968) · Armed Forces Institute of Pathology eBooks · Cited by 3,041 · see citing works
Hedley, D. W., Friedlander, M. L., Taylor, I. W., et al. (1983) · Journal of Histochemistry & Cytochemistry · doi:10.1177/31.11.6619538 · Cited by 2,056 · see citing works
A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis
Vindeløv, L. L., Christensen, I. J., & Nissen, N. I. (1983) · Cytometry · doi:10.1002/cyto.990030503 · Cited by 1,662 · see citing works
ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN
SAMPSON, J. A. (1925) · Archives of Surgery · doi:10.1001/archsurg.1925.01120100007001 · Cited by 765 · see citing works
Malignant neoplasms arising in endometriosis
Heaps, J., Rk, N., & Berek, J. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90262-4 · Cited by 396 · see citing works
Tumors of the ovary and maldeveloped gonads
Scully, R. E. (1979) · Armed Forces Institute of Pathology eBooks · Cited by 395 · see citing works
Malignant changes in endometriosis.
Rb, S. (1953) · PubMed · Cited by 290 · see citing works
MALIGNANT TUMORS ARISING IN ENDOMETRIOSIS
Mostoufi-Zadeh, M., & Scully, R. E. (1980) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198009000-00024 · Cited by 253 · see citing works
THE DEVELOPMENT OF MALIGNANCY IN ENDOMETRIOSIS
Scully, R. E., Richardson, G. S., & Barlow, J. F. (1966) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-196606000-00008 · Cited by 184 · see citing works
Malignancy arising in extragonadal endometriosis.A case report and summary of the world literature
Brooks, J. J. S., & Wheeler, J. E. (1977) · Cancer · doi:10.1002/1097-0142(197712)40:6 · Cited by 147 · see citing works
Friedlander, M. L., Hedley, D. W., Swanson, C. E., et al. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.2.282 · Cited by 127 · see citing works
Endometrioid carcinoma of the ovary and endometriosis: The association in postmenopausal women
DePriest, P. D., Banks, E. R., Powell, D. E., van Nagell, J. R., Gallion, H. H., Puls, L. E., Hunter, J. E., Kryscio, R. J., & Royalty, M. B. (1992) · Gynecologic Oncology · doi:10.1016/0090-8258(92)90079-x · Cited by 113 · see citing works
A case-control study of primary hepatocellular carcinoma in Taiwan
Lu, S., Lin, T., Chen, C., Chen, J. S., Liaw, Y., Chang, W., & Hsu, S. T. (1988) · Cancer · doi:10.1002/1097-0142(19881101)62:9 · Cited by 111 · see citing works
Flow cytometric deoxyribonucleic acid index: A prognostic factor in endometrial carcinoma
Iversen, O. E. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(86)80018-7 · Cited by 98 · see citing works
Malignancy arising in endometriosis associated with unopposed estrogen replacement.
REIMNITZ, C., Brand, E., Nieberg, R. K., & Hacker, N. F. (1988) · PubMed · Cited by 70 · see citing works
Clear cell (“mesonephroid”) adenocarcinoma of the vulva arising in endometriosis: A case report
Mesko, J. D., Gates, H., McDonald, T. W., Youmans, R., & Lewis, J. (1988) · Gynecologic Oncology · doi:10.1016/0090-8258(88)90241-7 · Cited by 58 · see citing works
Primary adrenocortical carcinoma causing aldosteronism
Alterman, S. L., Dominguez, C. J., Lopez-Gomez, A., & Lieber, A. L. (1969) · Cancer · doi:10.1002/1097-0142(196909)24:3 · Cited by 53 · see citing works
Kapadia, S. B., RUSSAK, R. R., O’Donnell, W. F., Harris, R. N., & Lecky, J. W. (1984) · Obstetrics and Gynecology · doi:10.1097/00006250-198409001-00016 · Cited by 49 · see citing works
Endometrioid and Clear Cell Carcinoma of the Ovary
Brescia, R. J., Dubin, N., & Demopoulos, R. I. (1989) · International Journal of Gynecological Pathology · doi:10.1097/00004347-198906000-00006 · Cited by 49 · see citing works
Carcinoma of the Ovary and Endometriosis
Aure, J. C., Høeg, K., & Kolstad, P. (1971) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347109157288 · Cited by 49 · see citing works
Prognostic Significance of Proliferation in Endometrial Adenocarcinomas
Stendahl, U., Strang, P. M., Wagenius, G., et al. (1991) · International Journal of Gynecological Pathology · doi:10.1097/00004347-199107000-00006 · Cited by 47 · see citing works
Malignant external endometriosis. A case of adenocarcinoma of umbilical endometriosis.
Lauslahti, K. (1972) · PubMed · Cited by 43 · see citing works
Endometrial stromal sarcoma arising from vaginal endometriosis.
Berkowitz, R. S., Ehrmann, R. L., & KNAPP, R. C. (1978) · PubMed · Cited by 42 · see citing works
DNA content as a prognostic factor in endometrial carcinoma
Newbury, R., Schuerch, C., Goodspeed, N., et al. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90627-h · Cited by 41 · see citing works
Malignant extraovarian endometriosis: Two case reports and review of the literature
Brunson, G. L., Barclay, D. L., Sanders, M. M., & Araoz, C. A. (1988) · Gynecologic Oncology · doi:10.1016/0090-8258(88)90055-8 · Cited by 39 · see citing works
MALIGNANCY ARISING IN EXTRAGONADAL ENDOMETRIOSIS
Brooks, J. J. S., & Wheeler, J. E. (1978) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-197807000-00021 · Cited by 35 · see citing works
Malignant transformation of vaginal endometriosis.
Granai, C. O., Walters, Safaii, H. S., Jelen, I., Madoc‐Jones, H., & Moukhtar, M. (1984) · PubMed · Cited by 35 · see citing works
Ferreira, H. P., & Clayton, S. G. (1958) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1958.tb06204.x · Cited by 34 · see citing works
Lindahl, B., Alm, P., Killander, D., et al. (1987) · PubMed · Cited by 31 · see citing works
Clear cell adenocarcinoma arising in endometriosis of the rectovaginal septum.
Goldberg, M. I., Jl, B., Ed, H., & Nordqvist, S. R. B. (1978) · PubMed · Cited by 29 · see citing works
Addison, W. A., Hammond, C. B., & Parker, R. T. (1979) · Gynecologic Oncology · doi:10.1016/0090-8258(79)90025-8 · Cited by 25 · see citing works
Kapp, D. S., Merino, M. J., & LiVolsi, V. A. (1982) · Gynecologic Oncology · doi:10.1016/0090-8258(82)90099-3 · Cited by 22 · see citing works
Vaginal adenocarcinoma developing in residual pelvic endometriosis: A clinical dilemma
Orr, J. W., Holimon, J. L., & Sisson, P. F. (1989) · Gynecologic Oncology · doi:10.1016/0090-8258(89)90611-2 · Cited by 21 · see citing works
Hyman, M. P. (1977) · American Journal of Clinical Pathology · doi:10.1093/ajcp/68.4.522 · Cited by 21 · see citing works
Shamsuddin, A. K. M., VillaSanta, U., Tang, C., & Mohamed, N. C. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90297-7 · Cited by 20 · see citing works
Flow cytometric DNA analysis in gynecological oncology
van Dam, P. A., Watson, J. V., Lowe, D. G., et al. (1992) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.1992.02020057.x · Cited by 18 · see citing works
Primary Adenocarcinoma of the Vagina
Bamford, D. S. (1967) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576706001029 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Malignant extraovarian endometriosis: A review
Benoit, L., Arnould, L., Cheynel, N., Diane, B., Causeret, S., Machado, A., Collin, F., Fraisse, J., & Cuisenier, J. (2006) · European Journal of Surgical Oncology (EJSO) · doi:10.1016/j.ejso.2005.08.011 · Cited by 108 · see citing works
Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: A meta-analysis
li, J., Liu, R., Tang, S., Feng, F., Liu, C., Wang, L., Zhao, W., Zhang, T., Yao, Y., Wang, X., et al. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-4968-1 · Cited by 56 · see citing works
Malignancies Associated with Extraovarian Endometriosis: A Literature Review
Inoue, N., Hirakawa, T., Mitsushita, J., Kitahara, Y., & Iwase, A. (2021) · Endocrines · doi:10.3390/endocrines2030024 · Cited by 7 · see citing works
“Moreover, various histological types of malignancy have been reported regarding extraovarian endometriosis: endometrioid stromal sarcoma, adenosarcoma, and carcinosarcoma [21].”
Background
- Authors
- Fishman, A., Demirel, D., Laucirica, R., Ramzy, I., Klima, T., Lyzak, J., & Kaplan, A. L.
- Affiliations
- Baylor College of Medicine (US)
- Baylor St. Luke's Medical Center (US)
- Corresponding author
- Fishman, Amiram
- ORCID
- Ramzy, Ibrahim
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 70
- Issue
- 1
- Pages
- 69-74
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2032934764
- Cited by
- 23
- References
- 37
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2016: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis-associated cancer, malignant transformation, endometrioid carcinoma, endometrial stromal sarcoma, ovarian cancer, DNA ploidy, S-phase fraction, prognostic factors, flow cytometry
- MeSH terms
- Adult, Aged, Cell Transformation, Neoplastic, DNA, Endometriosis, Female, Flow Cytometry, Genital Neoplasms, Female, Humans, Middle Aged, Ovarian Neoplasms, Pelvic Neoplasms, Ploidies, Prognosis, Retrospective Studies, Sarcoma, Vaginal Neoplasms, Endometrial Neoplasms, Carcinoma, Endometrioid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
