Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model
Abstract
Huntington's disease (HD) is a progressive inherited neurodegenerative disorder, for which there is no effective therapy. The CARE-HD study, recently published, evaluated the ability of a combination of coenzyme Q10 (CoQ10) and remacemide hydrochloride (R) to ameliorate symptoms, which might arise from glutamate-mediated excitotoxicity and abnormalities in mitochondrial energy production. In this study, we examined the efficacy of CoQ10/R therapy on ameliorating the motor dysfunction and premature death of HD-N171-82Q transgenic mice. Motor performance, measured on the Rotarod, was specifically but transiently improved beginning 3 weeks after initiating the CoQ10/R therapy. Survival, however was not prolonged. Our findings suggest that further study of CoQ10/R in mouse models is warranted to investigate whether this therapeutic approach can ameliorate the symptoms of HD in early stages of the disease.
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CoQ10 and remacemide combination therapy observed significantly improved motor performance and increased survival in the R6/2 and N-171-82Q transgenic mouse models of HD.
“Similarly, we and others, by using CoQ10 and remacemide (NMDA antagonist) combination therapy observed significantly improved motor performance and increased survival in the R6/2 and the N-171-82Q transgenic mouse models of HD151, 154.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [154]
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- Authors
- Schilling, G., Coonfield, M. L., Ross, C. A., & Borchelt, D. R.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Schilling, Gabriele
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 315
- Issue
- 3
- Pages
- 149-153
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2084728929
- Cited by
- 151
- References
- 20
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 4 · 2012: 14
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Huntington's disease, coenzyme Q10, motor impairment, rotarod performance, survival, glutamate excitotoxicity, mitochondrial energy production, neurodegeneration
- MeSH terms
- Huntingtin Protein, Acetamides, Animals, Antioxidants, Coenzymes, Drug Therapy, Combination, Huntington Disease, Mice, Transgenic, Motor Activity, Nerve Tissue Proteins, Nuclear Proteins, Peptide Fragments, Time Factors, Ubiquinone, Survival Analysis, Mice
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