The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
Abstract
The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, alleviated the pain behavior exhibited by CCI animals in a dose dependent manner. Moreover, at doses ranging from 0.43 to 4.3 mg/kg effects on sensitivity to a heat stimulus were observed neither in the paw contralateral to the sciatic ligation, nor in animals subjected to sham surgery. Animals subjected to CCI and treated with 4.3 mg/kg exhibited hypoalgesia in the paw ipsilateral to the ligated sciatic, i.e. heat hypoalgesia was completely reversed. The hypoalgesia is presumed to be the results of unmasking of a sensory deficit reflecting the known loss of C and A delta with CCI. Although side effects were present in some CCI animals subjected to the high dose (4.3 mg/kg), a moderate dose (2.14 mg/kg) completely alleviated the thermal and mechanical hyperalgesia, and mechanical allodynia without side effects. In addition to identifying a potential drug treatment for painful neuropathy, this study suggests that changes in cannabinoid receptors occurs in nerve injured animals.
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“SR141716, administered acutely, is pro-hyperalgesic and pro-allodynic in this model. 42”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [42]
Citations
Cites
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
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Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat
Tal, M., & Bennett, G. J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90058-s · Cited by 144
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Rice, A. S. C. (2003) · CRC Press eBooks · doi:10.1201/9780203911259.ch8
Diamante, L. M. (2022) · Eurasian Journal of Biological and Chemical Sciences · doi:10.46239/ejbcs.1141865
Chen, X., Yu, Q., & Shu, W. (2025) · Angewandte Chemie · doi:10.1002/ange.202423426
Davis, A., Casmedes, I. Y., & Burton, M. D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062813
Zintziovas, N., Karakosta, A., Voulgari, P. V., Stefanakis, G., Arnaoutoglou, E. M., Tzimas, P. G., & Micha, G. (2026) · Rheumatology International · doi:10.1007/s00296-026-06314-x · Cited by 1
Analgesic Properties of THC and Its Synthetic Derivatives
Lichtman, A. H., & Martin, B. R. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-710-9_50
Metadata
- Authors
- Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Herzberg, U
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 221
- Issue
- 2-3
- Pages
- 157-160
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1968446992
- Cited by
- 307
- References
- 15
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 14 · 2012: 12
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- cannabinoid receptor agonists, neuropathic pain, chronic constriction injury, sciatic nerve, analgesia, mechanical allodynia, thermal hyperalgesia, mechanical hyperalgesia, enantiomer specificity
- MeSH terms
- Rimonabant, Animals, Cannabinoids, Hot Temperature, Hyperalgesia, Injections, Intraperitoneal, Male, Morpholines, Naphthalenes, Pain, Peripheral Nervous System Diseases, Piperidines, Pyrazoles, Receptors, Drug, Rats, Sprague-Dawley, Analgesics, Non-Narcotic, Receptors, Cannabinoid, Benzoxazines, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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