Cited by 310Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Treatment

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

Herzberg, U, Eliav, E, Bennett, G.J, Kopin, Irwin J·1997·Neuroscience Letters

Open this paper in CoChat — free account

Abstract

The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, alleviated the pain behavior exhibited by CCI animals in a dose dependent manner. Moreover, at doses ranging from 0.43 to 4.3 mg/kg effects on sensitivity to a heat stimulus were observed neither in the paw contralateral to the sciatic ligation, nor in animals subjected to sham surgery. Animals subjected to CCI and treated with 4.3 mg/kg exhibited hypoalgesia in the paw ipsilateral to the ligated sciatic, i.e. heat hypoalgesia was completely reversed. The hypoalgesia is presumed to be the results of unmasking of a sensory deficit reflecting the known loss of C and A delta with CCI. Although side effects were present in some CCI animals subjected to the high dose (4.3 mg/kg), a moderate dose (2.14 mg/kg) completely alleviated the thermal and mechanical hyperalgesia, and mechanical allodynia without side effects. In addition to identifying a potential drug treatment for painful neuropathy, this study suggests that changes in cannabinoid receptors occurs in nerve injured animals.

Integrity signals

Registry

Crossref · 10.1016/s0304-3940(96)13308-5

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve
Tal, M., & Bennett, G. J. (1994) · Pain · doi:10.1016/0304-3959(94)90013-2 · Cited by 436
Biochemical and pharmacological characterisatioN OF SR141716A, the first potent and selective brain cannabinoid receptor antagonist
Rinaldi, M. L., Barth, F., Héaulme, M., Alonso, R., Shire, D. J., Congy, C., Soubrié, P., Brelière, J.-C., & Fur, G. L. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00174-5 · Cited by 307
Conformationally restrained analogs of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor
D'Ambra, T. E., Estep, K. G., Bell, M. R., Eissenstat, M. A., Josef, K. A., Ward, S. J., Haycock, D. A., Baizman, E. R., & Casiano, F. M. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00079a016 · Cited by 296
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy
Mao, J., Price, D. D., Hayes, R. L., Lü, J., Mayer, D. J., & Frenk, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91368-3 · Cited by 238
Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat
Tal, M., & Bennett, G. J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90058-s · Cited by 144
Modulation of cannabinoid-induced antinociception after intracerebroventricular versus intrathecal administration to mice: possible mechanisms for interaction with morphine.
Welch, S. P., Thomas, C., & Patrick, G. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24328-2 · Cited by 124
Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate
Carlton, S. M., Lekan, H. A., Kim, S. H., & Chung, J. M. (1994) · Pain · doi:10.1016/0304-3959(94)90090-6 · Cited by 121
Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2
Hohmann, A. G., Martin, W. J., Tsou, K., & Walker, J. M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00196-d · Cited by 120

Show all 15 references

Sorted by citations

Items 101–200 of 310

Endocannabinoid System: Chemical Characteristics and Biological Activity
Rezende, B., Alencar, A. K. N., de Bem, G. F., Fontes-Dantas, F. L., & Montes, G. C. (2023) · Pharmaceuticals · doi:10.3390/ph16020148 · Cited by 108
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms
Johanek, L. M., Heitmiller, D. R., Turner, M., Nader, N., Hodges, J., & Simone, D. A. (2001) · Pain · doi:10.1016/s0304-3959(01)00336-0 · Cited by 83
MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models
Naguib, M., Diaz, P., Xu, J. J., Astruc‐Diaz, F., Craig, S., Vivas‐Mejia, P., & Brown, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.340 · Cited by 82
Activation of spinal cannabinoid 1 receptors inhibits C‐fibre driven hyperexcitable neuronal responses and increases [35S]GTPγS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats
Drew, L., Harris, J. E., Millns, P. J., Kendall, D. A., & Chapman, V. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00101.x · Cited by 82
Cannabinoid WIN 55,212-2 inhibits the activity-dependent facilitation of spinal nociceptive responses
Strangman, N. M., & Walker, J. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.472 · Cited by 81
Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord
Salio, C., Doly, S., Fischer, J., Franzoni, M. F., & Conrath, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00549-9 · Cited by 81
Endocannabinoids in pain modulation
Walker, J. M., & Huang, S. M. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0361 · Cited by 79
The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats
Ellington, H. C., Cotter, M. A., Cameron, N. E., & Ross, R. A. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00040-0 · Cited by 79
Antinociceptive Action of Isolated Mitragynine from Mitragyna Speciosa through Activation of Opioid Receptor System
Shamima, A. R., Fakurazi, S., Hidayat, M. T., Hairuszah, I., Moklas, M. A. M., & Arulselvan, P. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911427 · Cited by 78
Actions of N-Arachidonyl-Glycine in a Rat Inflammatory Pain Model
Succar, R., Mitchell, V. A., & Vaughan, C. W. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-24 · Cited by 77
Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain
Seltzman, H. H., Shiner, C., Hirt, E. E., Gilliam, A. F., Thomas, B. F., Maitra, R., Snyder, R. W., Black, S. R., Patel, P. R., Mulpuri, Y., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00516 · Cited by 75
Endocannabinoids: Effectors of glucocorticoid signaling
Balsevich, G., Petrie, G. N., & Hill, M. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.005 · Cited by 82
Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones
Ahluwalia, J., Urbán, L., Bevan, S., Capogna, M., & Nagy, I. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00601-7 · Cited by 75
CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System
Romero, T. R. L., Resende, L. C., Guzzo, L. S., & Duarte, I. D. G. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182707859 · Cited by 74
Are oral cannabinoids safe and effective in refractory neuropathic pain?
Attal, N., Brasseur, L., Guirimand, D., Clermond‐Gnamien, S., Atlami, S., & Bouhassira, D. (2004) · European Journal of Pain · doi:10.1016/s1090-3801(03)00084-3 · Cited by 74
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats
Ulugöl, A., Karadağ, Ç. H., İpçi, Y., Tamer, M., & Dökmeci, İ. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.061 · Cited by 73
Cannabis and Cannabinoids: Pharmacology and Rationale for Clinical Use
Pertwee, R. G. (1999) · Complementary Medicine Research · doi:10.1159/000057150 · Cited by 72
Cannabinoids as potential new analgesics
Fuentes, J., Ruiz‐Gayo, M., Manzanares, J., Vela, G., Reche, I., & Corchero, J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00290-8 · Cited by 72
Opioid and cannabinoid synergy in a mouse neuropathic pain model
Kazantzis, N. P., Casey, S. L., Seow, P. W., Mitchell, V. A., & Vaughan, C. W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13534 · Cited by 71
Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain
Gutierrez, T., Crystal, J. D., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pain · doi:10.1016/j.pain.2011.03.038 · Cited by 71
Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat
de Novellis, V., Mariani, L., Palazzo, E., Vita, D., Marabese, I., Scafuro, M. A., Rossi, F., & Maione, S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.014 · Cited by 71
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model
Barnes, N. S. A., Mitchell, V. A., Kazantzis, N. P., & Vaughan, C. W. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13337 · Cited by 72
Towards cannabinoid drugs – revisited
Mechoulam, R., Hanus, L. O., & Fride, E. (1998) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(08)70037-7 · Cited by 70
The Synthetic Cannabinoid R(+)WIN 55,212-2 Inhibits the Interleukin-1 Signaling Pathway in Human Astrocytes in a Cannabinoid Receptor-independent Manner
Curran, N., Griffin, B. D., O’Toole, D. P., Brady, K. J., Fitzgerald, S. N., & Moynagh, P. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507959200 · Cited by 69
Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development
Vry, J. D., Jentzsch, K. R., Kuhl, E., & Eckel, G. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200402000-00001 · Cited by 69
The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain
Liang, Y.-C., Huang, C.-C., & Hsu, K.-S. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.019 · Cited by 68
Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy
Vera, G., Cabezos, P. A., Martín, M. I., & Abalo, R. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.02.008 · Cited by 68
Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
Flores, Á., Maldonado, R. J., & Berrendero, F. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00256 · Cited by 74
The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy
Wallace, V. C. J., Segerdahl, A. R., Lambert, D. M., Vandevoorde, S., Blackbeard, J., Pheby, T., Hasnie, F., & Rice, A. S. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707326 · Cited by 66
Antinociception and modulation of rostral ventromedial medulla neuronal activity by local microinfusion of a cannabinoid receptor agonist
Meng, I. D., & Johansen, J. P. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.001 · Cited by 65
Effects of Smoked Cannabis and Oral δ9-Tetrahydrocannabinol on Nausea and Emesis After Cancer Chemotherapy
Musty, R. E., & Rossi, R. (2001) · Journal of Cannabis Therapeutics · doi:10.1300/j175v01n01_03 · Cited by 64
Zebrafish models relevant to studying central opioid and endocannabinoid systems
Demin, K. A., Мешалкина, Д. А., Kysil, E. V., Antonova, K. A., Volgin, A. D., Yakovlev, O. A., Alekseeva, P. A., Firuleva, M. M., Lakstygal, A. M., de Abreu, M. S., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.024 · Cited by 67
CB1 receptor mediated analgesia from the Nucleus Reticularis Gigantocellularis pars alpha is activated in an animal model of neuropathic pain
Monhemius, R., Azami, J., Green, D. L., & Roberts, M. H. T. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02605-1 · Cited by 64
3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
De Vry, J., Denzer, D., Reissmueller, E., Eijckenboom, M., Heil, M., Meier, H., & Mauler, F. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.062836 · Cited by 63
Analysis of the Endocannabinoid System by Using CB1 Cannabinoid Receptor Knockout Mice
Valverde, O., Karsak, M., & Zimmer, A. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_4 · Cited by 61
CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain
Deng, L., Cornett, B., Mackie, K., & Hohmann, A. G. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098483 · Cited by 60
Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation
Mulpuri, Y., Marty, V. N., Munier, J. J., Mackie, K., Schmidt, B. L., Seltzman, H. H., & Spigelman, I. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.002 · Cited by 62
Participation of the opioid system in cannabinoid-induced antinociception and emotional-like responses
Maldonado, R. J., & Valverde, O. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.001 · Cited by 62
Analgesic and antihyperalgesic effects of nabilone on experimental heat pain
Redmond, W. J., Goffaux, P., Potvin, S., & Marchand, S. (2008) · Current Medical Research and Opinion · doi:10.1185/030079908x280635 · Cited by 63
Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect
Doğrul, A., Gül, H., Yıldız, O., Bilgin, F., & Güzeldemir, M. E. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.060 · Cited by 61
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain
Hama, A. T., & Sagen, J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.010 · Cited by 61
The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder
Jaggar, S., Sellaturay, S., & Rice, A. S. C. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00621-1 · Cited by 60
Therapeutic potential of cannabinoid receptor agonists as analgesic agents
Fox, A., & Bevan, S. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.6.695 · Cited by 60
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats
Khasabova, I. A., Simone, D. A., & Seybold, V. S. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00449-9 · Cited by 59
Cannabis Reduces Opioid Dose in the Treatment of Chronic Non-Cancer Pain
Lynch, M. E., & Clark, A. J. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(03)00142-8 · Cited by 56
Photochemical Asymmetric Nickel‐Catalyzed Acyl Cross‐Coupling
Gandolfo, E., Tang, X., Roy, S. R., & Melchiorre, P. (2019) · Angewandte Chemie · doi:10.1002/ange.201910168 · Cited by 56
Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists
Rooney, L., Vidal, A., D’Souza, A.-M., Devereux, N., Masick, B. T., Boissel, V., West, R., Head, V., Stringer, R. A., Lao, J., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401986p · Cited by 54
Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia
Hamamoto, D. T., Giridharagopalan, S., & Simone, D. A. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.062 · Cited by 55
Pharmacological Characterization of a Novel Cannabinoid Ligand, MDA19, for Treatment of Neuropathic Pain
Xu, J. J., Diaz, P., Astruc‐Diaz, F., Craig, S. L., Muñoz, E., & Naguib, M. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181e0cdaf · Cited by 51
Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
Dogrul, A. B., Seyrek, M., Yalçın, B., & Ulugöl, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.01.007 · Cited by 52
Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(−/−) and not CB2(−/−) mice in models of acute and persistent pain
Sain, N. M. H., Liang, A., Kane, S. A., & Urban, M. O. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.004 · Cited by 51
Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception
Ahn, D. K., Choi, H. S., Yeo, S. P., Woo, Y. W., Lee, M. K., Yang, G. Y., Jeon, H., Park, J. S., & Mokha, S. S. (2007) · Pain · doi:10.1016/j.pain.2007.01.015 · Cited by 51
Cannabinoid receptors and pain
Starowicz, K., Małek, N., & Przewłocka, B. (2013) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.83 · Cited by 50
A Comparative Evaluation of Illicit Drug use in Patients with or Without Controlled Substance Abuse in Interventional Pain Management
Manchikanti, L. (2003) · Pain Physician · doi:10.36076/ppj.2003/6/281 · Cited by 50
Central glucocorticoid receptors regulate the upregulation of spinal cannabinoid-1 receptors after peripheral nerve injury in rats
Wang, S., Lim, G., Mao, J., Sung, B., Yang, L., & Mao, J. (2007) · Pain · doi:10.1016/j.pain.2006.12.019 · Cited by 46
Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain
Hollinshead, S. P., Tidwell, M. W., Palmer, J. R., Guidetti, R., Sanderson, A. J., Johnson, M. P., Chambers, M. G., Oskins, J. L., Stratford, R. E., & Astles, P. C. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400305d · Cited by 45
Management of neuropathic pain in children with cancer
Friedrichsdorf, S. J., & Nugent, A. P. (2013) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283615ebe · Cited by 46
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats
Zaniewska, M., McCreary, A. C., Przegaliński, E., & Filip, M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.04.034 · Cited by 46
Cannabinoids and Pain
Walker, J. M., Strangman, N. M., & Huang, S. M. (2001) · Pain Research and Management · doi:10.1155/2001/413641 · Cited by 46
Decreased basal endogenous opioid levels in diabetic rodents: Effects on morphine and delta-9-tetrahydrocannabinoid-induced antinociception
Williams, J., Haller, V. L., Stevens, D. L., & Welch, S. P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.035 · Cited by 45
Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors
Hamann, W., & di Vadi, P. P. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05429-4 · Cited by 45
Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models
Mitchell, V. A., Greenwood, R., Jayamanne, A., & Vaughan, C. W. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04692.x · Cited by 43
AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors
La Rana, G., Russo, R., D'Agostino, G., Sasso, O., Raso, G. M., Iacono, A., Meli, R., Piomelli, D., & Calignano, A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.10.021 · Cited by 42
Development and expression of neuropathic pain in CB1 knockout mice
Castañé, A., Célèrier, E., Martín, M., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.07.022 · Cited by 42
Cannabinoid receptor‐independent actions of the aminoalkylindole WIN 55,212‐2 on trigeminal sensory neurons
Price, T. J., Patwardhan, A. M., Akopian, A. N., Hargreaves, K., & Flores, C. M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705778 · Cited by 43
Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes
Vera, G., López‐Miranda, V., Herradón, E., Martı́n, M. I., & Abalo, R. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.05.008 · Cited by 41
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy
Nasirinezhad, F., Jergová, S., Pearson, J. P., & Sagen, J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.024 · Cited by 41
Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury
Hama, A., & Sagen, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.09.002 · Cited by 40
Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain
Leichsenring, A., Andriske, M., Bäcker, I., Stichel, C. C., & Lübbert, H. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-008-0386-4 · Cited by 39
Cannabis-based medicines in multiple sclerosis – A review of clinical studies
Rog, D. J. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.03.009 · Cited by 39
Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice
Comelli, F., Bettoni, I., Colombo, A., Fumagalli, P., Giagnoni, G., & Costa, B. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.061 · Cited by 39
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain
Liu, C., & Walker, J. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00498.2006 · Cited by 37
Peripheral analgesia: Hitting pain where it hurts
McDougall, J. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.011 · Cited by 38
Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain
Luo, Y., Zhang, J., Chen, L., Chen, S.-R., Chen, H., Zhang, G.-F., & Pan, H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011053 · Cited by 37
Pain in Birds
Douglas, J. M., Guzman, D. S.-M., & Paul‐Murphy, J. (2017) · Veterinary Clinics of North America Exotic Animal Practice · doi:10.1016/j.cvex.2017.08.008 · Cited by 38
Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception
Hama, A. T., & Sagen, J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.004 · Cited by 36
Analysis of natural product regulation of opioid receptors in the treatment of human disease
Badal, S. A. M., Turfus, S. C., Rajnarayanan, R. V., Wilson-Clarke, C. F., & Sandiford, S. L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.021 · Cited by 36
Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase D immunoreactivity in the superficial spinal dorsal horn of rats
Hegyi, Z., Holló, K., Kis, G., Mackie, K., & Antal, M. (2012) · Glia · doi:10.1002/glia.22351 · Cited by 31
AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation
Rodella, L. F., Borsani, E., Rezzani, R., Ricci, F., Buffoli, B., & Bianchi, R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.12.031 · Cited by 32
Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy
Tamba, B.-I., Stanciu, G. D., Urîtu, C. M., Rezuş, E., Ştefănescu, R., Mihai, C. T., Luca, A., Rusu-Zota, G., Leon, M. M., Cojocaru, E., et al. (2020) · Medicina · doi:10.3390/medicina56010024 · Cited by 32
Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors
Kargar, H. M.-P., Azizi, H., Mirnajafi‐Zadeh, J., Mani, A. R., & Semnanian, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.050 · Cited by 32
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice
Hoot, M. R., Sim‐Selley, L. J., Poklis, J. L., Abdullah, R. A., Scoggins, K. L., Selley, D. E., & Dewey, W. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.105 · Cited by 34
Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain
Mitchell, V. A., Aslan, S. C., Safaei, R., & Vaughan, C. W. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.03.019 · Cited by 31
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain
Uhelski, M. L., Cain, D. M., Harding-Rose, C., & Simone, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.003 · Cited by 30
Treatment of Chronic Intractable Neuropathetic Pain with Dronabinol: Case Report of Two Adolescents
Rudich, Z., Stinson, J., Jeavons, M., & Brown, S. C. (2003) · Pain Research and Management · doi:10.1155/2003/675976 · Cited by 30
Neuropathic Pain and Sickle Cell Disease: a Review of Pharmacologic Management
Orhurhu, M. S., Chu, R., Claus, L. E., Roberts, J. S., Salisu, B., Urits, I., Orhurhu, E., Viswanath, O., Kaye, A. D., Kaye, A. J., et al. (2020) · Current Pain and Headache Reports · doi:10.1007/s11916-020-00885-5 · Cited by 28
Local Peripheral Effects of β-Caryophyllene through CB2 Receptors in Neuropathic Pain in Mice
Kuwahata, H., Katsuyama, S., Komatsu, T., Nakamura, H., Corasaniti, M. T., Bagetta, G., Sakurada, S., Sakurada, T., & Takahama, K. (2012) · Pharmacology & Pharmacy · doi:10.4236/pp.2012.34053 · Cited by 29
Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis
Łuszczki, J. J., & Florek-Łuszczki, M. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70867-8 · Cited by 28
Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat
Abalo, R., Cabezos, P. A., Vera, G., López-Pérez, A. E., & Martı́n, M. I. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12073 · Cited by 28
Diabetic thermal hyperalgesia: Role of TRPV1 and CB1 receptors of periaqueductal gray
Mohammadi-Farani, A., Sahebgharani, M., Sepehrizadeh, Z., Jaberi, E., & Ghazi‐Khansari, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.077 · Cited by 28
Local application of the cannabinoid receptor agonist, WIN 55,212–2, to spinal trigeminal nucleus caudalis differentially affects nociceptive and non-nociceptive neurons
Papanastassiou, A. M., Fields, H. L., & Meng, I. D. (2003) · Pain · doi:10.1016/j.pain.2003.11.009 · Cited by 28
Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain
Ahmed, M. M., Rajpal, S., Sweeney, C., Gerovac, T. A., Allcock, B., McChesney, S. L., Patel, A. U., Tilghman, J. I., Miranpuri, G. S., & Resnick, D. K. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.08.015 · Cited by 26
Ultra-low dose naltrexone enhances cannabinoid-induced antinociception
Paquette, J. J., & Olmstead, M. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200512000-00001 · Cited by 26
CB1-cannabinoid-, TRPV1-vanilloid- and NMDA-glutamatergic-receptor-signalling systems interact in the prelimbic cerebral cortex to control neuropathic pain symptoms
de Medeiros, P. S., Oliveira-Silva, M., Negrini-Ferrari, S. E., Medeiros, A. C., Elias-Filho, D. H., Coimbra, N. C., & de Freitas, R. L. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.09.013 · Cited by 27
Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease
Badal, S. A. M., Smith, K. N., & Rajnarayanan, R. V. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.06.003 · Cited by 27
Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats
Chapman, V. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00125-3 · Cited by 25
The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases
Tudorancea, I. M., Ciorpac, M., Stanciu, G. D., Caratașu, C.-C., Săcărescu, A., Ignat, B. E., Burlui, A., Rezuş, E., Creangă-Murariu, I., Alexa‐Stratulat, T., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102492 · Cited by 28
Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands
Yang, J., Williams, A. H., Penthala, N. R., Prather, P. L., Crooks, P. A., & Zhan, C. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00551 · Cited by 25
Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice
Gündüz, Ö., Karadağ, Ç. H., & Ulugöl, A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.05.029 · Cited by 25
Using Cannabis to Treat Cancer-Related Pain
Byars, T., Theisen, E., & Bolton, D. L. (2019) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2019.04.012 · Cited by 25

Authors: Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Herzberg, U
ORCID: Herzberg, U
Eliav, E
Kopin, Irwin J
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1997-01
Volume: 221
Issue: 2-3
Pages: 157-160
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/s0304-3940(96)13308-5
OpenAlex: W1968446992
Cited by: 307
References: 15
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 14 · 2012: 12
FWCI: 10.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: cannabinoid receptor agonists, neuropathic pain, chronic constriction injury, sciatic nerve, analgesia, mechanical allodynia, thermal hyperalgesia, mechanical hyperalgesia, enantiomer specificity
MeSH terms: Rimonabant, Animals, Cannabinoids, Hot Temperature, Hyperalgesia, Injections, Intraperitoneal, Male, Morpholines, Naphthalenes, Pain, Peripheral Nervous System Diseases, Piperidines, Pyrazoles, Receptors, Drug, Rats, Sprague-Dawley, Analgesics, Non-Narcotic, Receptors, Cannabinoid, Benzoxazines, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks