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Evidence for activation of microglia in patients with psychiatric illnesses
Abstract
Activation of microglia/macrophages is a key event in response to pathological changes in the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with activated microglia cells. In order to elucidate a potential role of microgliosis in severe psychiatric illnesses, post-mortem frontal cortex and hippocampus of patients with schizophrenia (n = 14) and affective disorder (n = 6) and control specimens (n = 13) were studied. Additionally Alzheimer's disease cases (n = 8) were included as a human model system with typical neurodegenerative alterations and microglia activation. All patient groups revealed subjects with abundant microglia immunostaining (schizophrenia, three patients; affective disorder, one patient; Alzheimer's disease, four patients) in both gray and white matter. This finding provides evidence for distinct neuropathological changes in brains of patients with schizophrenia and affective disorder. The activation of microglia cells, which represent a major part of the brain immune response, may help to unravel the pathophysiological processes in severe psychiatric illnesses.
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“In this context, the neuropathology of schizophrenia has been reported to be closely associated with cytokines and microglial activation (Bayer et al., 1999; Brown, 2011; Juckel et al., 2011; Meyer et al., 2009; Monji et al., 2009; Najjar et al., 2013; Radewicz et al., 2000; Vuillermot et al., 2010).”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Bayer et al., 1999
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Metadata
- Authors
- Bayer, T. A., Buslei, R., Havas, L., & Falkai, P.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Bayer, Thomas A
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 271
- Issue
- 2
- Pages
- 126-128
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2069782517
- Cited by
- 323
- References
- 19
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 13 · 2018: 26 · 2017: 22 · 2016: 18 · 2015: 22 · 2014: 26 · 2013: 27 · 2012: 18
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- microglial activation, HLA-DR, schizophrenia, mood disorders, bipolar disorder, Alzheimer's disease, postmortem brain, frontal cortex, hippocampus, neuroinflammation, brain immune response, neuropathology
- MeSH terms
- Aged, Mental Disorders, Female, HLA-DR Antigens, Humans, Immunohistochemistry, Macrophage Activation, Male, Middle Aged, Schizophrenia, Microglia, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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