The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The effect of opioids on phantom limb pain and cortical reorganization
Abstract
The efficacy of oral retarded morphine sulphate (MST) was tested against placebo in a double-blind crossover design in 12 patients with phantom limb pain after unilateral leg or arm amputation. Two counterbalanced treatment phases of 4 weeks each were initiated with an intravenous test infusion of MST or Placebo. The titration phase was 2 weeks. The dose of MST was titrated to at least 70 mg/day and at highest 300 mg/day. Pain intensity was assessed hourly on visual analog scales during a 4-week treatment-free phase, both treatment phases and at two follow-ups (6 and 12 months). Reorganization of somatosensory cortex, electric perception and pain thresholds as well as selective attention were measured pre- and post-treatment. A significant pain reduction was found during MST but not during placebo. A clinically relevant response to MST (pain reduction of more than 50%) was evident in 42%, a partial response (pain reduction of 25-50%) in 8% of the patients. Neuromagnetic source imaging of three patients showed initial evidence for reduced cortical reorganization under MST concurrent with the reduction in pain intensity. Perception and pain thresholds were not significantly altered whereas attention was significantly lower under MST. Thus, opioids show efficacy in the treatment of phantom limb pain and may potentially influence also cortical reorganization. These data need to be replicated in larger patient samples.
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Cites
A self-rating depression scale
ZUNG, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01720310065008 · Cited by 9,813 · cited 1×
“At all ®ve time points the Self-Rating Depression Scale (SDS, Zung, 1965) was used to assess depression since it has few somatic items and is therefore also suitable for patients with chronic pain.”
MethodThe McGill Pain Questionnaire: Major properties and scoring methods
Melzack, R. (1975) · Pain · doi:10.1016/0304-3959(75)90044-5 · Cited by 6,845
Detecting Alcoholism: The CAGE Questionnaire
Ewing, J. A. (1984) · JAMA · doi:10.1001/jama.1984.03350140051025 · Cited by 3,005
The West Haven-Yale Multidimensional Pain Inventory (WHYMPI)
Kerns, R. D., Turk, D. C., & Rudy, T. E. (1985) · Pain · doi:10.1016/0304-3959(85)90004-1 · Cited by 2,128
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Flor, H., Elbert, T., Knecht, S., Wienbruch, C., Pantev, C., Birbaumers, N., Larbig, W., & Taub, E. (1995) · Nature · doi:10.1038/375482a0 · Cited by 1,845
Self-citationCredibility of analogue therapy rationales
Borkovec, T. D., & Nau, S. D. (1972) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(72)90045-6 · Cited by 1,553 · cited 1×
“In order to assess expected treatment outcome, a visual analogue scale of 10 cm length with the endpoints `not at all' and `very high' was used (Borkovec and Nau, 1972; Flor, 1991).”
MethodLack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
Arnér, S., & Meyerson, B. A. (1988) · Pain · doi:10.1016/0304-3959(88)90198-4 · Cited by 991
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899
Portenoy, R. K., Foley, K. M., & Inturrisi, C. E. (1990) · Pain · doi:10.1016/0304-3959(90)90025-9 · Cited by 565
Birbaumer, N., Lutzenberger, W., Montoya, P., Larbig, W., Unertl, K., Töpfner, S., Grodd, W., Taub, E., & Flor, H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05503.1997 · Cited by 484
Self-citation
Cited by
Dworkin, R. H., Turk, D. C., Wyrwich, K. W., Beaton, D., Cleeland, C. S., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Kerns, R. D., Ader, D. N., et al. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.005 · Cited by 3,471
Pharmacologic management of neuropathic pain: Evidence-based recommendations
Dworkin, R. H., O’Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., Kalso, E. A., Loeser, J. D., Miaskowski, C., Nurmikko, T. J., et al. (2007) · Pain · doi:10.1016/j.pain.2007.08.033 · Cited by 2,126
EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision
Attal, N., Cruccu, G., Baron, R., Haanpää, M., Hansson, P., Jensen, T. S., & Nurmikko, T. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.02999.x · Cited by 1,873
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216
McNicol, E. D., Midbari, A., & Eisenberg, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006146.pub2 · Cited by 434
Metadata
- Authors
- Huse, E., Larbig, W., Flor, H., & Birbaumer, N.
- Venue
- Pain
- Published
- 2001-02
- Volume
- 90
- Issue
- 1
- Pages
- 47-55
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2077547311
- Cited by
- 309
- References
- 34
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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