Cited by 482Cancer Treatment and PharmacologyPain Mechanisms and TreatmentsChemotherapy-related skin toxicity

The DOI matches its Crossref record; 77 of the 79 references it cites were found in a registry or an index.

A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

Polomano, Rosemary C., Mannes, Andrew J., Clark, Uraina S., Bennett, Gary J.·2001·Pain

Open this paper in CoChat — free account

Abstract

Paclitaxel, an effective anti-neoplastic agent in the treatment of solid tumors, produces a dose-limiting painful peripheral neuropathy in a clinically significant number of cancer patients. Prior work has demonstrated paclitaxel-induced neurodegeneration and sensory loss in laboratory rodents. We describe here an experimental paclitaxel-induced painful peripheral neuropathy. Adult male rats were given four intraperitoneal injections on alternate days of vehicle or 0.5, 1.0, or 2.0 mg/kg of paclitaxel (Taxol). Behavioral tests for pain using mechanical and thermal stimuli applied to the tail and hind paws, and tests for motor performance, were taken before, during and after dosing for 22-35 days. All three doses of paclitaxel caused heat-hyperalgesia, mechano-allodynia, mechano-hyperalgesia, and cold-allodynia, but had no effect on motor performance. Neuropathic pain began within days and lasted for several weeks. We did not detect any dose-response relationship. Tests at the distal, mid, and proximal tail failed to show evidence of a length-dependent neuropathy. Vehicle control injections had no effect on any measure. No significant systemic toxicities were noted in the paclitaxel-treated animals. Light-microscopic inspection of the sciatic nerve (mid-thigh level), L4-L5 dorsal root ganglia, and dorsal and ventral roots, and the gray and white matter of the L4-L5 spinal cord, showed no structural abnormalities. Electron microscopic examination of the sciatic nerve (mid-thigh level) and the L4-L5 dorsal root ganglia and dorsal horns demonstrated no degeneration of myelinated and unmyelinated axons in the sciatic nerve and roots, but revealed endoneurial edema. This model may be useful in understanding a significant source of pain in cancer patients, and in finding ways to avoid the neurotoxicity that limits paclitaxel therapy.

Integrity signals

Registry

Crossref · 10.1016/s0304-3959(01)00363-3

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer
McGuire, W. P., Hoskins, W. J., Brady, M. F., Kucera, P. R., Partridge, E. E., Look, K. Y., Clarke‐Pearson, D. L., & Davidson, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340101 · Cited by 2,798
Taxol stabilizes microtubules in mouse fibroblast cells.
Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971
Paclitaxel (Taxol)
Rowinsky, E. K., & Donehower, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321507 · Cited by 1,924
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
Yoon, C., Wook, Y. Y., Na, H. S., Ho, K. S., & Mo, C. J. (1994) · Pain · doi:10.1016/0304-3959(94)90023-x · Cited by 868
Regression Analysis for Correlated Data
Liang, K., & Zeger, S. L. (1993) · Annual Review of Public Health · doi:10.1146/annurev.pu.14.050193.000355 · Cited by 765
Clinical toxicities encountered with paclitaxel (Taxol).
Rowinsky, E. K., Eisenhauer, E. A., Chaudhry, V., Sg, A., & Rc, D. (1993) · PubMed · Cited by 692
Taxol binds to polymerized tubulin in vitro
Parness, J., & Horwitz, S. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.2.479 · Cited by 624

Show all 79 references

Research works printed but not linked: 2

Fan, 1999, Possible mechanisms of paclitaxel-induced apoptosis., Biochem Pharmacol, 57, 1215
Polomano, 1998, Paclitaxel-induced painful peripheral neuropathy in rats., Soc Neurosci Abstr, 24, 381

Sorted by citations

Items 301–400 of 482

Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models
Bianco, M. R., Cirillo, G., Petrosino, V., Marcello, L., Soleti, A., Merizzi, G., Cavaliere, C., & Papa, M. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.08.088 · Cited by 13
Transcriptome Profiling of miRNA-mRNA Interactions and Associated Mechanisms in Chemotherapy-Induced Neuropathic Pain
Yang, X.-H., Huang, X., Lu, W., Yan, F., Ye, Y., Wang, L., Tang, X., Zeng, W., Huang, J., & Xie, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03398-5 · Cited by 12
Neuropathy, its Profile and Experimental Nerve Injury Neuropathic Pain Models: A Review
Sharma, K. K., Fatima, N., Ali, Z., Moshin, M., Chandra, P., Verma, A. K., Goshain, O., & Kumar, G. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128274200231128065425 · Cited by 12
7-Chloro-4-(Phenylselanyl) Quinoline Is a Novel Multitarget Therapy to Combat Peripheral Neuropathy and Comorbidities Induced by Paclitaxel in Mice
Paltian, J. J., dos Reis, A. S., Martins, A. W. S., Blödorn, E. B., Dellagostin, E. N., Soares, L. K., Schumacher, R. F., Campos, V. F., Alves, D. A. C., Luchese, C., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02991-4 · Cited by 12
Drug-Induced Myopathy and Neuropathy
Saleh, F. G., & Seidman, R. (2003) · Journal of Clinical Neuromuscular Disease · doi:10.1097/00131402-200312000-00003 · Cited by 12
Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]
Li, Z., Han, X., Hong, X., Li, X., Gao, J., Zhang, H., & Zheng, A. (2021) · Marine Drugs · doi:10.3390/md19030121 · Cited by 12
Dynamic long-term microstructural and ultrastructural alterations in sensory nerves of rats of paclitaxel-induced neuropathic pain
Yuan, W., Li, J., Junfei, Z., & Feng, Y. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20140727 · Cited by 12
Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice
Kamei, J., Hayashi, S.-S., Akane, S., Nakanishi, Y., Kai, M., Ikegami, M., & Ikeda, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171819 · Cited by 12
Paw withdrawal thresholds and persistent hindlimb flexion in experimental mononeuropathies
Wallas, T. R., Winterson, B. J., Ransil, B. J., & Bove, G. M. (2003) · Journal of Pain · doi:10.1016/s1526-5900(03)00619-9 · Cited by 12
Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models
Fotio, Y., Sasso, O., Ciccocioppo, R., & Piomelli, D. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000674 · Cited by 11
Neuroimaging uncovers neuronal and metabolic changes in pain modulatory brain areas in a rat model of chemotherapy-induced neuropathy – MEMRI and ex vivo spectroscopy studies
Costa‐Pereira, J. T., Oliveira, R., Guadilla, I., Guillén, M. J., Tavares, I., & López‐Larrubia, P. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.10.018 · Cited by 11
The Potential Antinociceptive Effect and Mechanism of Cannabis sativa L. Extract on Paclitaxel-Induced Neuropathic Pain in Rats Uncovered by Multi-Omics Analysis
Xu, Y., Yao, L., Guo, Y., Shi, C., Zhou, J., & Hua, M. (2024) · Molecules · doi:10.3390/molecules29091958 · Cited by 11
Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel
Pennypacker, S. D., Fonseca, M. M., Morgan, J. W., Dougherty, P. M., Cubillos‐Ruiz, J. R., Strowd, R. E., III, & Romero-Sandoval, E. A. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2021.12.019 · Cited by 11
Spinal Cord Mechanisms of Hyperalgesia and Allodynia
Coderre, T. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00168-7 · Cited by 12
Paclitaxel-induced hyperalgesia modulates negative affective component of pain and NR1 receptor expression in the frontal cortex in rats
Noda, K., Akita, H., Ogata, M., & Saji, M. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.01.002 · Cited by 11
Hyperbaric oxygen produces a nitric oxide synthase-regulated anti-allodynic effect in rats with paclitaxel-induced neuropathic pain
Zhang, Y., Brewer, A. L., Nelson, J. T., Smith, P. T., Shirachi, D. Y., & Quock, R. M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.01.009 · Cited by 11
FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors
Wang, G., Zhang, X., Pan, X., & Yun, X. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135471 · Cited by 11
Neuroprotective Effect of Ramipril Is Mediated by AT2 in a Mouse MODEL of Paclitaxel-Induced Peripheral Neuropathy
Bouchenaki, H., Bernard, A., Bessaguet, F., Frachet, S., Richard, L., Sturtz, F. G., Magy, L., Bourthoumieu, S., Demiot, C., & Danigo, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040848 · Cited by 11
Upregulation of neuronal progranulin mediates the antinociceptive effect of trimetazidine in paclitaxel-induced peripheral neuropathy: Role of ERK1/2 signaling
Nasser, A. H., Gendy, A. M., El-Yamany, M. F., & El-Tanbouly, D. M. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116096 · Cited by 11
Effect of Ethyl Pyruvate on Paclitaxel-Induced Neuropathic Pain in Rats
Choi, S.-S., Koh, W. U., Nam, J., Shin, J. W., Leem, J. G., & Suh, J. H. (2013) · The Korean journal of pain · doi:10.3344/kjp.2013.26.2.135 · Cited by 11
Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice
Lobos, N., Lux, S., Zepeda, R., Pélissier, T., Marcos, J. L., Bustos-Quevedo, G., Hernández, A., & Constandil, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098359 · Cited by 10
Attenuation of p38 MAPK / NF ‐ κB / TRPV1 / CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐induced peripheral neuropathy
Elaleem, W. S. A., Ghaiad, H. R., Abd‐Elmawla, M. A., & Shaheen, A. A. (2024) · BioFactors · doi:10.1002/biof.2125 · Cited by 13
Pain Testing in the Laboratory Mouse
Langford, D. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012373898-1.00023-2 · Cited by 10
Peripheral Neuropathy in a Woman With Breast Cancer
Cianfrocca, M. E., Flatters, S. J. L., Bennett, G. J., McNicol, E. D., Relias, V., Carr, D. B., & Gillis, T. A. (2006) · Journal of Pain · doi:10.1016/j.jpain.2005.10.001 · Cited by 10
A cannabinoid pharmacotherapy for chemotherapy-evoked painful peripheral neuropathy
Hohmann, A. G. (2005) · Pain · doi:10.1016/j.pain.2005.07.007 · Cited by 10
Pretreatment of Shaoyao Gancao Decoction (芍药甘草汤) alters pharmacokinetics of intravenous paclitaxel in rats
Wang, Y., Huang, X., Mei-zuo, Z., Lu, R., Xia, Z.-A., Fan, R., Liu, B., Huang, W. C., & Gan, P. (2016) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-016-2619-6 · Cited by 9
Subacute toxicity and toxicokinetics study of DHP107, an oral paclitaxel formulation with once-weekly dosing in mice
Kim, J., Lee, S., Kim, Y., Jeong, E. J., Lee, I., Son, M., Lee, J., Kim, S. K., & Moon, K. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.02.004 · Cited by 9
Neurobiological studies of chronic pain and analgesia: Rationale and refinements
Fairbanks, C. A., & Goracke‐Postle, C. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.049 · Cited by 9
Recovery Sleep Does Not Mitigate the Effects of Prior Sleep Loss on Paclitaxel-Induced Mechanical Hypersensitivity in Sprague-Dawley Rats
Kozachik, S., Opp, M. R., & Page, G. G. (2014) · Biological Research For Nursing · doi:10.1177/1099800414539385 · Cited by 9
Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms
Vitet, L., Patte‐Mensah, C., Boujedaini, N., Mensah‐Nyagan, A. G., & Meyer, L. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3575-z · Cited by 9
Chemotherapy-Induced Neuropathic Pain
Raffa, R. B., Langford, R. M., Pergolizzi, J. V., Porreca, F., & Tallarida, R. J. (2012) · CRC Press eBooks · doi:10.1201/b12366 · Cited by 10
The synergistic anti-nociceptive effects of nefopam and gabapentinoids in inflammatory, osteoarthritis, and neuropathic pain mouse models
Xiao, X., Chen, Y., Zhu, J., Yin, M.-Y., Huang, C.-N., Qin, H.-M., Liu, S., Xiao, Y., Fang, H.-W., Zhuang, T., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176738 · Cited by 9
Evaluation of Lercanidipine in Paclitaxel-Induced Neuropathic Pain Model in Rat: A Preliminary Study
Saha, L., Hota, D., & Chakrabarti, A. (2012) · Pain Research and Treatment · doi:10.1155/2012/143579 · Cited by 8
Resistance of Food-Maintained Operant Responding to Mechanical Punishment in Rats: Further Evidence for Weak “Affective/Motivational Pain” in Rat Models of Inflammatory and Neuropathic Pain
Negus, S. S., Marsh, S. A., & Townsend, E. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.615782 · Cited by 8
Simultaneous hyperbaric oxygen therapy during systemic chemotherapy reverses chemotherapy-induced peripheral neuropathy by inhibiting TLR4 and TRPV1 activation in the central and peripheral nervous system
Chou, P., Lu, C.-Y., Kan, J., Wang, S.-H., Lo, J.-J., Huang, S., & Wu, S. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06269-8 · Cited by 8
Cancer pain syndromes
Twycross, R., & Bennett, M. (2008) · CRC Press eBooks · doi:10.1201/b13440-3 · Cited by 8
Comparison of paclitaxel and cisplatin effects on the slowly adapting type I mechanoreceptor
Zhang, J., & Tuckett, R. P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.069 · Cited by 8
Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice
Whitaker, E. E., Mecum, N. E., Cott, R. C., & Goode, D. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298396 · Cited by 7
The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies
Duarte, D. B., & Vasko, M. R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384999-1.10013-7 · Cited by 7
JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
Filipiuc, L.-E., Creangă-Murariu, I., Tamba, B.-I., Ababei, D. C., Rusu, R.-N., Stanciu, G. D., Ştefănescu, R., Ciorpac, M., Szilagyi, A., Gogu, M.-R., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-67154-y · Cited by 9
Caffeic Acid Phenethyl Ester (CAPE) Attenuates Paclitaxel-induced Peripheral Neuropathy: A Mechanistic Study
Sharma, S. S., Kulkarni, N. P., Vaidya, B., & Narula, A. S. (2022) · Current Neurovascular Research · doi:10.2174/1567202619666220829104851 · Cited by 7
Les principaux syndromes douloureux liés au cancer
George, B., & Delfieu, D. (2008) · ONCOLOGIE · doi:10.1007/s10269-008-0959-3 · Cited by 7
TMI-1, TNF-α-Converting Enzyme Inhibitor, Protects Against Paclitaxel-Induced Neurotoxicity in the DRG Neuronal Cells In Vitro
Kim, Y., Jung, Y.-H., Park, S.-B., Kim, H., Kwon, J.-Y., Kim, H.-K., Lee, H., Jeon, S., & Kim, E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.842779 · Cited by 7
Effect of chronic vincristine treatment on mechanical withdrawal response and pre-pulse inhibition in the rat
Borzan, J., LaGraize, S. C., & Fuchs, P. N. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.032 · Cited by 7
An animal model of chemotherapy‐induced vagal neuropathy
Weissman‐Fogel, I., Dashkovsky, A., Rogowski, Z., & Yarnitsky, D. (2008) · Muscle & Nerve · doi:10.1002/mus.21152 · Cited by 6
Cancer Pain — The Role of an Integrated, Comprehensive Rehabilitation Program in Its Management
Saggini, R., Bellomo, R. G., Carmignano, S. M., & Saggini, A. (2015) · InTech eBooks · doi:10.5772/60548 · Cited by 6
Behavior and electrophysiology studies of the peripheral neuropathy induced by individual and co-administration of paclitaxel and oxaliplatin in rat
Paniagua, N., Sánchez-Robles, E., Bagüés, A., Martı́n, M. I., Goicoechea, C., & Girón, R. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119397 · Cited by 5
Identifying circRNA–miRNA–mRNA Regulatory Networks in Chemotherapy-Induced Peripheral Neuropathy
Cao, F., Wang, X., Ye, Q., Yan, F., Lu, W., Xie, J., Bi, B., & Wang, X. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45080430 · Cited by 5
The refined biomimetic NeuroDigm GEL™ Model of neuropathic pain in the mature rat
Hannaman, M. R., Fitts, D. A., Doss, R. M., Weinstein, D. E., & Bryant, J. (2016) · F1000Research · doi:10.12688/f1000research.9544.2 · Cited by 6
NYX-2925, A NOVEL, NON-OPIOID, SMALL-MOLECULE MODULATOR OF THE N-METHYL-d-ASPARTATE RECEPTOR (NMDAR), DEMONSTRATES POTENTIAL TO TREAT CHRONIC, SUPRASPINAL CENTRALIZED PAIN CONDITIONS
Gajda, J. M., Asiedu, M. N., Morrison, G., Dunning, J. A., Ghoreishi-Haack, N. S., & Barth, A. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100067 · Cited by 5
Systemic, Intrathecal, and Intracerebroventricular Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512–2 Toxin in Persistent Pain Models
Cavalli, J., de Assis, P. M., Gonçalves, E. C. D., Bobermin, L. D., Quincozes‐Santos, A., Raposo, N. R. B., Gomez, M. V., & Dutra, R. C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02864-w · Cited by 4
Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia
Lu, C., Ye, F., Luo, Q., Wang, Z., Wang, Y., Xia, Z., & Shu, H. (2018) · BioScience Trends · doi:10.5582/bst.2018.01037 · Cited by 5
Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel induced Neuropathy: Isobolographic Analysis
Ofori, A. E., Eric, W., Kyei, S., Robert, B. P., & Boampong, J. N. (2015) · Pharmacognosy Journal · doi:10.5530/pj.2015.6.8 · Cited by 5
The Self-administration of Analgesic Drugs in Experimentally Induced Chronic Pain
Wade, C. L., & Fairbanks, C. A. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_344 · Cited by 5
Intrathecal administration of the Nav1.7 inhibitor PF-05089771 produces rapid and side-effect-free analgesia in mice.
Zhou, X.-L., Zhou, X.-L., Ji, M.-J., Xu, P., Cox, J. J., Zhao, J., & Zhang, C.-J. (2025) · Pain · doi:10.1097/j.pain.0000000000003823 · Cited by 7
ApoA-I binding protein (AIBP) regulates transient receptor potential vanilloid 1 (TRPV1) activity in rat dorsal root ganglion neurons by selective disruption of toll-like receptor 4 (TLR4)-lipid rafts
Li, Y., Uhelski, M. L., North, R. Y., Farson, L. B., Bankston, C. B., Roland, G. H., Fan, D. H., Sheffield, K. N., Jia, A., Orlando, D., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.017 · Cited by 5
Ozanimod, a functional sphingosine-1-phosphate receptor 1 antagonist, restores brainstem descending pain pathways in murine models of neuropathic pain
Giancotti, L. A., Squillace, S., Chen, Z., Lauro, F., Li, Y., & Salvemini, D. (2025) · Pain · doi:10.1097/j.pain.0000000000003770 · Cited by 4
A Hyperresponsive HPA Axis May Confer Resilience Against Persistent Paclitaxel-Induced Mechanical Hypersensitivity
Kozachik, S., & Page, G. G. (2015) · Biological Research For Nursing · doi:10.1177/1099800415609418 · Cited by 4
Goshajinkigan improves paclitaxel-induced peripheral neuropathy in rats
Hashimoto, K., Sakuma, Y., & Kotani, J. (2006) · Journal of Osaka Dental University · doi:10.18905/jodu.40.1_47 · Cited by 4
Effects of Benfotiamine and Methylcobalamin on Paclitaxel Induced Peripheral Neuropathy
Dizaye, K. F., & Qadir, C. Y. (2014) · Middle East Journal of Internal Medicine · doi:10.5742/meim.2014.92404 · Cited by 4
Small Synthetic Hyaluronan Disaccharide BIS014 Mitigates Neuropathic Pain in Mice
Padín, J. F., Maroto, M., Entrena, J. M., Egea, J., Montell, E., Vergés, J., López, M. G., Cobos, E. J., & García, A. G. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.07.014 · Cited by 4
Preventive and therapeutic effects of JM-20 on paclitaxel-evoked painful peripheral neuropathy in rats
Garrido‐Suárez, B. B., Garrido, G., Menéndez, A. B., Aparicio, G., Valdés, O., Ochoa, E., Verdecia-Reyes, Y., & Delgado, R. (2021) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres20.970_9.2.165 · Cited by 4
Therapeutic effects of melittin on paclitaxel-induced peripheral neuropathic pain and spinal neuronal hyperactivity in male rats
Li, D., Wu, Y., Chang, L., Song, Y., Du, X., Xue, F., Liu, Y., Wu, J., & Wang, T. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1622553 · Cited by 4
Morphological manifestations of experimental paclitaxel-induced sciatic neuropathy under correction of 2-ethyl-6-methyl-3-hydroxypyridine succinate
Ostrovskyi, M. M. (2021) · ScienceRise Medical Science · doi:10.15587/2519-4798.2021.232975 · Cited by 3
Lidocaine Enhanced Antitumor Efficacy and Relieved Chemotherapy-Induced Hyperalgesia in Mice with Metastatic Gastric Cancer
Gao, P., Peng, F., Liu, J., Wu, W., Zhao, G., Liu, C., Cao, H., Li, Y., Qiu, F., & Zhang, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020828 · Cited by 3
Drug Addiction and Chronic Pain: A Review of Animal Models
Wade, C. L., Koob, G. F., & Vendruscolo, L. F. (2014) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-1856-0_5 · Cited by 3
La evaluación del dolor experimental en el laboratorio: los modelos de dolor neuropático en animales
Baños, J.-E., & Ruiz, G. (2006) · Hispana · Cited by 3
Mecanismos del dolor neuropático: Del laboratorio a la clínica
Gómez-Barrios, J. V., & Tortorici, V. (2009) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 3
Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats
Pinheiro, K. D. V., Brusco, I., Hausen, B. S., Moresco, R. N., Rigo, F. K., Oliveira, S. M., & Ferreira, J. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00702-w · Cited by 3
Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid Derivatives with possible HCN channel binding ability
Saini, A., Sharma, S., Rana, P., Khanna, B., Kaur, T., & Dhingra, N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05088-w · Cited by 2
Plant-Derived Secondary Metabolites Tetrahydropalmatine and Rutaecarpine Alleviate Paclitaxel-Induced Neuropathic Pain via TRPV1 and TRPM8 Modulation
Park, K.-T., Yun, H., Kang, J., Lee, J.-C., & Kim, W. (2026) · Metabolites · doi:10.3390/metabo16010046 · Cited by 2
Design and Characterization of a Dual COX-2/Ca V 2.2 Inhibitor with Potent Analgesic Activity
Qiu, J., Tao, S., Zhang, T., Miao, Z., Hu, S., Liu, W., Su, J., Hai, A., Huang, Z., Liu, J., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02649 · Cited by 2
Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses
Lamberti, A., Lozano, V. M., Fernández-Carvajal, A. M., & Ferrer-Montiel, A. V. (2026) · FEBS Journal · doi:10.1111/febs.70517 · Cited by 2
Paclitaxel triggers molecular and cellular changes in the choroid plexus
Zamani, A., EmamiAref, P., Kubíčková, L., Hašanová, K., Šandor, O., Dubový, P., & Joukal, M. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1488369 · Cited by 2
Morpho-Functional State of the Spinal Nodes in Paclitaksel-Induced Neuropathy Corrected by Armadin
Ostrovskyi, M. M. (2019) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs04.06.074 · Cited by 2
Vascular endothelial growth factor and HDAC 6: a neuroprotective signalling pathway against cancer therapy-induced neuropathy
Garrido, J. J. (2012) · Brain · doi:10.1093/brain/aws227 · Cited by 2
Central Analgesic Activity
Daniel, V. (2015) · Springer eBooks · doi:10.1007/978-3-319-05392-9_40 · Cited by 2
A Comparative Study between the Effect of Nerve Growth Factor and All-Trans Retinoic Acid versus their combined use on Taxol Induced Peripheral Neuropathy in Adult Male Albino Rat
Moghazy, H. M., Abdelrahman, A., Haliem, N. G. A. E., Elnady, H. M., & lotfy, A. (2019) · The Egyptian Journal of Histology · doi:10.21608/ejh.2019.7080.1063 · Cited by 2
Noncancer-Related Pain in Daily Practice
Żylicz, Z. (2013) · Springer eBooks · doi:10.1007/978-0-85729-230-8_14 · Cited by 2
[Animal models of neuropathic pain].
Sasaki, A., & Kuraishi, Y. (2006) · Folia Pharmacologica Japonica · doi:10.1254/fpj.127.151 · Cited by 2
Peripheral Neuropathy Due to Chemotherapy and Radiation Therapy
Driver, L., Cata, J. P., & Phan, P. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-0261-5.50016-8 · Cited by 2
Clavulanic acid prevents paclitaxel-induced neuropathic pain through a systemic and central anti-inflammatory effect in mice
Balcazar-Ochoa, L. G., López, G. E. Á., Chavarría, A., Carreto, R. J. R., González‐Hernández, A., Guzmán‐Ruiz, M. A., Mendoza, M. S., Ochoa-Aguilar, A., & Ventura‐Martínez, R. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00522 · Cited by 1
Gaussian white noise stimulation as an alternative method to excite sensory neurons
Losgott, T., Schicker, K. W., Hilber, K., Boehm, S., & Salzer, I. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1561905 · Cited by 1
Neurobehavioral manifestations in female rats after intermittent exposure to an anticancer agent, paclitaxel
Pathak, D., & Singh, K. P. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000833 · Cited by 1
Multifaced roles of cannabinoid therapy in cancer: balancing analgesia, antitumor potential, and systemic toxicity
Creangă-Murariu, I., Ciorpac, M., Gogu, M.-R., Pricope, C. V., Bild, V., Ababei, D. C., Filipiuc, L.-E., Szilagyi, A., Josan, C.-L., Caruntu, I.-D., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1691893 · Cited by 1
Dynamics of hippocampal morphological changes in condition of cisplatin and paclitaxel combined administration
Kulynych, H. B., Herashchenko, S. B., Fedorak, V. M., Yurah, H. Y., Polyvkan, M. I., & Атаманчук, О. В. (2026) · Reports of Morphology · doi:10.31393/morphology-journal-2026-32(1)-01 · Cited by 1
Experimental assessment of the temporal dynamics of motor impairments in neuropathy induced by paclitaxel, cisplatin, and their concomitant administration
Kulynych, H. B., Herashchenko, S. B., Островський, М., & Polyvkan, M. I. (2026) · The Journal of V N Karazin Kharkiv National University series Medicine · doi:10.26565/2313-6693-2026-58-04 · Cited by 1
Lymphotoxin-beta receptor controls the development of chronic pain
Tumanov, A. V., Mecklenburg, J. M., Belugin, S., Naratadam, G. T., Barba-Escobedo, P. A., Todd, A. W., Koroleva, E., Hovhannisyan, A. H., Shein, S. A., Tamada, K., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117269 · Cited by 1
Pain syndromes in cancer survivors
Polomano, R. C., Ashburn, M. A., & Farrar, J. T. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511642357.009 · Cited by 1
Acupuncture and Moxibustion in Animal Models of Cancer
Zhang, R.-X., & Lao, L. (2012) · Evidence-based anticancer complementary and alternative medicine · doi:10.1007/978-94-007-4833-0_13 · Cited by 1
Common characteristics and pathways in neuropathic pain of different etiologies
Vadakkan, K. I., Xu, H., & Zhuo, M. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.12.001 · Cited by 1
Portulaca oleracea inhibit vincristine induced peripheral neuropathy: involvement of ATP-sensitive K+ channels
Rupa, L. M., Mohan, K. K. L. A. J., & Kumar, N. (2014) · International Journal of Basic & Clinical Pharmacology · doi:10.5455/2319-2003.ijbcp20140611 · Cited by 1
Antiallodynic Effect of Hyperbaric Oxygen on Paclitaxel-Induced Peripheral Neuropathy in a Model of Rat and Its Mechanism
Miao, T., Meng, X., He, H., & Ji, X. (2019) · OALib · doi:10.4236/oalib.1105339 · Cited by 1
Histological examination of peripheral neuropathy caused by paclitaxel
Hashimoto, K., Sakuma, Y., & Kotani, J. (2004) · Journal of Osaka Dental University · doi:10.18905/jodu.38.1_53 · Cited by 1
The effect of hand therapy on alleviating chemotherapy-induced peripheral neuropathy in a model mouse
Shinouchi, R., Sasaki, A., Takaki, T., Tsuji, M., Kiuchi, Y., & Nobe, K. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137138 · Cited by 1
The Future of Chemotherapy: The Mechanisms and Benefits of Exercise in Taxane-Induced Peripheral Neuropathy
Shastry, S., Mizrahi, D., & Kanzawa-Lee, G. A. (2023) · Physiologia · doi:10.3390/physiologia3040042 · Cited by 1
Neuroprotective effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the sciatic nerve and its segmental centers in experimental paclitaxel-induced peripheral neuropathy
Herashchenko, S. B., Островський, М., Kulynych, H. B., & Markiv, I. M. (2023) · Reports of Morphology · doi:10.31393/morphology-journal-2023-29(4)-10 · Cited by 1
Management of pain at end of life
Paice, J. A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2242-0.00079-1 · Cited by 1
Insights into the Contribution of Voltage-Gated Sodium Channel 1.7 to Paclitaxel-Induced Neuropathy
Bernal, L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0692-18.2018 · Cited by 1
The Correlation of the Grading of Chemotherapy-Induced Peripheral Neurotoxicity (CIPN) Using the Total Neuropathy Score-Reduced and Various Electrophysiological Parameters in Breast Cancer Patients
Kim, S., Yang, H.-J., & Koh, S.-J. (2019) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2019.1.5 · Cited by 1

Authors: Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J.
Affiliations: Pennsylvania State University (US)
University of Pennsylvania (US)
Hahnemann University Hospital (US)
Corresponding author: Polomano, Rosemary C.
ORCID: Polomano, Rosemary C.
Mannes, Andrew J.
Clark, Uraina S.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-12
Volume: 94
Issue: 3
Pages: 293-304
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(01)00363-3
OpenAlex: W1991677710
Cited by: 476
References: 79
Citations by year: 2026: 20 · 2025: 10 · 2024: 18 · 2023: 18 · 2022: 16 · 2021: 35 · 2020: 30 · 2019: 27 · 2018: 28 · 2017: 30 · 2016: 18 · 2015: 17 · 2014: 30 · 2013: 21 · 2012: 28
FWCI: 2.62
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
United States Pharmacopeia
National Institutes of Health (5k01nr000136-03)
National Institute of Nursing Research (KO1 NR 00136-01A1)
Topics: Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Keywords: paclitaxel, chemotherapy-induced peripheral neuropathy, neuropathic pain, thermal hyperalgesia, mechanical allodynia, cold allodynia, sciatic nerve, dorsal root ganglia, endoneurial edema, axonal degeneration, rat model, dose-response relationship, length-dependent neuropathy
MeSH terms: Animals, Antineoplastic Agents, Phytogenic, Behavior, Animal, Cold Temperature, Disease Models, Animal, Hot Temperature, Hindlimb, Hyperalgesia, Male, Motor Activity, Peripheral Nervous System Diseases, Physical Stimulation, Tail, Rats, Sprague-Dawley, Paclitaxel, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks