Cited by 482Cancer Treatment and PharmacologyPain Mechanisms and TreatmentsChemotherapy-related skin toxicity

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A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

Polomano, Rosemary C., Mannes, Andrew J., Clark, Uraina S., Bennett, Gary J.·2001·Pain

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Abstract

Paclitaxel, an effective anti-neoplastic agent in the treatment of solid tumors, produces a dose-limiting painful peripheral neuropathy in a clinically significant number of cancer patients. Prior work has demonstrated paclitaxel-induced neurodegeneration and sensory loss in laboratory rodents. We describe here an experimental paclitaxel-induced painful peripheral neuropathy. Adult male rats were given four intraperitoneal injections on alternate days of vehicle or 0.5, 1.0, or 2.0 mg/kg of paclitaxel (Taxol). Behavioral tests for pain using mechanical and thermal stimuli applied to the tail and hind paws, and tests for motor performance, were taken before, during and after dosing for 22-35 days. All three doses of paclitaxel caused heat-hyperalgesia, mechano-allodynia, mechano-hyperalgesia, and cold-allodynia, but had no effect on motor performance. Neuropathic pain began within days and lasted for several weeks. We did not detect any dose-response relationship. Tests at the distal, mid, and proximal tail failed to show evidence of a length-dependent neuropathy. Vehicle control injections had no effect on any measure. No significant systemic toxicities were noted in the paclitaxel-treated animals. Light-microscopic inspection of the sciatic nerve (mid-thigh level), L4-L5 dorsal root ganglia, and dorsal and ventral roots, and the gray and white matter of the L4-L5 spinal cord, showed no structural abnormalities. Electron microscopic examination of the sciatic nerve (mid-thigh level) and the L4-L5 dorsal root ganglia and dorsal horns demonstrated no degeneration of myelinated and unmyelinated axons in the sciatic nerve and roots, but revealed endoneurial edema. This model may be useful in understanding a significant source of pain in cancer patients, and in finding ways to avoid the neurotoxicity that limits paclitaxel therapy.

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Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer
McGuire, W. P., Hoskins, W. J., Brady, M. F., Kucera, P. R., Partridge, E. E., Look, K. Y., Clarke‐Pearson, D. L., & Davidson, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340101 · Cited by 2,798
Taxol stabilizes microtubules in mouse fibroblast cells.
Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971
Paclitaxel (Taxol)
Rowinsky, E. K., & Donehower, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321507 · Cited by 1,924
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
Yoon, C., Wook, Y. Y., Na, H. S., Ho, K. S., & Mo, C. J. (1994) · Pain · doi:10.1016/0304-3959(94)90023-x · Cited by 868
Regression Analysis for Correlated Data
Liang, K., & Zeger, S. L. (1993) · Annual Review of Public Health · doi:10.1146/annurev.pu.14.050193.000355 · Cited by 765
Clinical toxicities encountered with paclitaxel (Taxol).
Rowinsky, E. K., Eisenhauer, E. A., Chaudhry, V., Sg, A., & Rc, D. (1993) · PubMed · Cited by 692
Taxol binds to polymerized tubulin in vitro
Parness, J., & Horwitz, S. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.2.479 · Cited by 624

Show all 79 references

Research works printed but not linked: 2

Fan, 1999, Possible mechanisms of paclitaxel-induced apoptosis., Biochem Pharmacol, 57, 1215
Polomano, 1998, Paclitaxel-induced painful peripheral neuropathy in rats., Soc Neurosci Abstr, 24, 381

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Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound
Bordet, T., Berna, P. P., Abitbol, J., & Pruss, R. M. (2010) · Pharmaceuticals · doi:10.3390/ph3020345 · Cited by 127
Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1
Gao, W., Zan, Y., Wang, Z.-J. J., Hu, X.-Y., & Huang, F. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.58 · Cited by 120
Animal Models of Chemotherapy-Evoked Painful Peripheral Neuropathies
Authier, N., Balayssac, D., Marchand, F., Ling, B., Zangarelli‌, A., Descoeur, J., Coudoré, F., Bourinet, E., & Eschalier, A. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.003 · Cited by 120
Cancer Chemotherapy-Related Symptoms: Evidence to Suggest a Role for Proinflammatory Cytokines
Wood, L. J., Nail, L. M., Gilster, A., Winters, K. A., & Elsea, C. R. (2006) · Oncology nursing forum · doi:10.1188/06.onf.535-542 · Cited by 120
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats
Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I. (2005) · Pain · doi:10.1016/j.pain.2005.07.008 · Cited by 117
Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats
Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats
Okubo, K., Takahashi, T., Sekiguchi, F., Kanaoka, D., Matsunami, M., Ohkubo, T., Yamazaki, J., Fukushima, N., Yoshida, S., & Kawabata, A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.004 · Cited by 116
Effects of natural and synthetic isothiocyanate-based H 2 S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels
Mannelli, L. D. C., Lucarini, E., Micheli, L., Mosca, I., Ambrosino, P., Soldovieri, M. V., Martelli, A., Testai, L., Taglialatela, M., Calderone, V., et al. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.029 · Cited by 116
CXCL5 Mediates UVB Irradiation–Induced Pain
Dawes, J. M., Calvo, M., Perkins, J. R., Paterson, K. J., Kiesewetter, H., Hobbs, C., Kaan, T. K. Y., Orengo, C. A., Bennett, D., & McMahon, S. B. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002193 · Cited by 116
Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms
Imai, S., Koyanagi, M., Azimi, Z., Nakazato, Y., Matsumoto, M., Ogihara, T., Yonezawa, A., Omura, T., Nakagawa, S., Wakatsuki, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05784-1 · Cited by 114
Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models
Favre‐Guilmard, C., Auguet, M., & Chabrier, P. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.047 · Cited by 114
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice
Segat, G. C., Manjavachi, M. N., Matias, D. O., Passos, G. F., Freitas, C. S., da Costa, R., & Calixto, J. Β. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.015 · Cited by 113
Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia
Cata, J. P., Weng, H., Chen, J.-H., & Dougherty, P. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.009 · Cited by 108
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways
Janes, K., Esposito, E., Doyle, T. M., Cuzzocrea, S., Tosh, D. K., Jacobson, K. A., & Salvemini, D. (2014) · Pain · doi:10.1016/j.pain.2014.09.016 · Cited by 111
Controlling murine and rat chronic pain through A 3 adenosine receptor activation
Chen, Z., Janes, K., Chen, C., Doyle, T. M., Bryant, L., Tosh, D. K., Jacobson, K. A., & Salvemini, D. (2012) · The FASEB Journal · doi:10.1096/fj.11-201541 · Cited by 107
Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model
Ji, X., Qian, N., Zhang, T., Li, J., Li, X., Wang, P., Zhao, D., Huang, G., Zhang, L., Zhou, F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060733 · Cited by 107
The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries
Zheng, F. Y., Xiao, W. H., & Bennett, G. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.052 · Cited by 106
Melatonin limits paclitaxel‐induced mitochondrial dysfunction in vitro and protects against paclitaxel‐induced neuropathic pain in the rat
Galley, H. F., McCormick, B., Wilson, K. L., Lowes, D. A., Colvin, L., & Torsney, C. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12444 · Cited by 103
Dysfunction in Multiple Primary Afferent Fiber Subtypes Revealed By Quantitative Sensory Testing in Patients with Chronic Vincristine-Induced Pain
Dougherty, P. M., Cata, J. P., Burton, A. W., Vu, K., & Weng, H. (2007) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2006.08.006 · Cited by 105
The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats
Cata, J. P., Weng, H., & Dougherty, P. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.001 · Cited by 102
Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells
Burgos, E., Gómez‐Nicola, D., Pascual, D., Martı́n, M. I., Nieto‐Sampedro, M., & Goicoechea, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.008 · Cited by 99
Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia
Weng, H., Aravindan, N., Cata, J. P., Chen, J.-H., Shaw, A., & Dougherty, P. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.049 · Cited by 99
Chemotherapy-Induced Peripheral Neuropathy
Fehrenbacher, J. C. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.12.002 · Cited by 104

Authors: Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J.
Affiliations: Pennsylvania State University (US)
University of Pennsylvania (US)
Hahnemann University Hospital (US)
Corresponding author: Polomano, Rosemary C.
ORCID: Polomano, Rosemary C.
Mannes, Andrew J.
Clark, Uraina S.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-12
Volume: 94
Issue: 3
Pages: 293-304
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(01)00363-3
OpenAlex: W1991677710
Cited by: 476
References: 79
Citations by year: 2026: 20 · 2025: 10 · 2024: 18 · 2023: 18 · 2022: 16 · 2021: 35 · 2020: 30 · 2019: 27 · 2018: 28 · 2017: 30 · 2016: 18 · 2015: 17 · 2014: 30 · 2013: 21 · 2012: 28
FWCI: 2.62
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
United States Pharmacopeia
National Institutes of Health (5k01nr000136-03)
National Institute of Nursing Research (KO1 NR 00136-01A1)
Topics: Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Keywords: paclitaxel, chemotherapy-induced peripheral neuropathy, neuropathic pain, thermal hyperalgesia, mechanical allodynia, cold allodynia, sciatic nerve, dorsal root ganglia, endoneurial edema, axonal degeneration, rat model, dose-response relationship, length-dependent neuropathy
MeSH terms: Animals, Antineoplastic Agents, Phytogenic, Behavior, Animal, Cold Temperature, Disease Models, Animal, Hot Temperature, Hindlimb, Hyperalgesia, Male, Motor Activity, Peripheral Nervous System Diseases, Physical Stimulation, Tail, Rats, Sprague-Dawley, Paclitaxel, Rats

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A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

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