Cited by 482Cancer Treatment and PharmacologyPain Mechanisms and TreatmentsChemotherapy-related skin toxicity

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A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

Polomano, Rosemary C., Mannes, Andrew J., Clark, Uraina S., Bennett, Gary J.·2001·Pain

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Abstract

Paclitaxel, an effective anti-neoplastic agent in the treatment of solid tumors, produces a dose-limiting painful peripheral neuropathy in a clinically significant number of cancer patients. Prior work has demonstrated paclitaxel-induced neurodegeneration and sensory loss in laboratory rodents. We describe here an experimental paclitaxel-induced painful peripheral neuropathy. Adult male rats were given four intraperitoneal injections on alternate days of vehicle or 0.5, 1.0, or 2.0 mg/kg of paclitaxel (Taxol). Behavioral tests for pain using mechanical and thermal stimuli applied to the tail and hind paws, and tests for motor performance, were taken before, during and after dosing for 22-35 days. All three doses of paclitaxel caused heat-hyperalgesia, mechano-allodynia, mechano-hyperalgesia, and cold-allodynia, but had no effect on motor performance. Neuropathic pain began within days and lasted for several weeks. We did not detect any dose-response relationship. Tests at the distal, mid, and proximal tail failed to show evidence of a length-dependent neuropathy. Vehicle control injections had no effect on any measure. No significant systemic toxicities were noted in the paclitaxel-treated animals. Light-microscopic inspection of the sciatic nerve (mid-thigh level), L4-L5 dorsal root ganglia, and dorsal and ventral roots, and the gray and white matter of the L4-L5 spinal cord, showed no structural abnormalities. Electron microscopic examination of the sciatic nerve (mid-thigh level) and the L4-L5 dorsal root ganglia and dorsal horns demonstrated no degeneration of myelinated and unmyelinated axons in the sciatic nerve and roots, but revealed endoneurial edema. This model may be useful in understanding a significant source of pain in cancer patients, and in finding ways to avoid the neurotoxicity that limits paclitaxel therapy.

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Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer
McGuire, W. P., Hoskins, W. J., Brady, M. F., Kucera, P. R., Partridge, E. E., Look, K. Y., Clarke‐Pearson, D. L., & Davidson, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340101 · Cited by 2,798
Taxol stabilizes microtubules in mouse fibroblast cells.
Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971
Paclitaxel (Taxol)
Rowinsky, E. K., & Donehower, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321507 · Cited by 1,924
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
Yoon, C., Wook, Y. Y., Na, H. S., Ho, K. S., & Mo, C. J. (1994) · Pain · doi:10.1016/0304-3959(94)90023-x · Cited by 868
Regression Analysis for Correlated Data
Liang, K., & Zeger, S. L. (1993) · Annual Review of Public Health · doi:10.1146/annurev.pu.14.050193.000355 · Cited by 765
Clinical toxicities encountered with paclitaxel (Taxol).
Rowinsky, E. K., Eisenhauer, E. A., Chaudhry, V., Sg, A., & Rc, D. (1993) · PubMed · Cited by 692
Taxol binds to polymerized tubulin in vitro
Parness, J., & Horwitz, S. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.2.479 · Cited by 624

Show all 79 references

Research works printed but not linked: 2

Fan, 1999, Possible mechanisms of paclitaxel-induced apoptosis., Biochem Pharmacol, 57, 1215
Polomano, 1998, Paclitaxel-induced painful peripheral neuropathy in rats., Soc Neurosci Abstr, 24, 381

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Hopkins, H. L., Duggett, N. A., & Flatters, S. J. L. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000204 · Cited by 49
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Zang, X., Lee, J. B., Deshpande, K., Garbuzenko, O. B., Minko, T., & Kagan, L. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.013 · Cited by 47
Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape
Kim, H. K., Lee, S. Y., Koike, N., Kim, E., Wirianto, M., Burish, M. J., Yagita, K., Lee, H. K., Chen, Z., Chung, J. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70757-w · Cited by 50
Tempol Ameliorates and Prevents Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain
Kim, H. K., Hwang, S.-H., & Abdi, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00532 · Cited by 46
Peripheral neuropathy due to paclitaxel: study of the temporal relationships between the therapeutic schedule and the clinical quantitative score (QST) and comparison with neurophysiological findings
Caraceni, A. T., Pietro, M., Cinzia, M., Sergio, C., Cresta, S., Gianni, L., & Scaioli, V. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9438-8 · Cited by 46
Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α2-Adrenergic Receptor
Choi, J. H., Jeon, C., Lee, J. H., Jang, J. U., Quan, F., Lee, K., Kim, W., & Kim, S. K. (2017) · Toxins · doi:10.3390/toxins9110351 · Cited by 45
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit
Slivicki, R. A., Saberi, S. A., Iyer, V., Vemuri, K. V., Makriyannis, A., & Hohmann, A. G. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.252288 · Cited by 45
Study of nuclear factor-2 erythroid related factor-2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats
Singh, J., Saha, L., Singh, N., Kumari, P., Bhatia, A., & Chakrabarti, A. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13047 · Cited by 45
Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone
Ullah, R., Ali, G., Subhan, F., Naveed, M., Khan, A., Khan, J., Halim, S. A., Ahmad, N., Zakiullah, & Al‐Harrasi, A. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104981 · Cited by 45
Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture
Pittman, S. K., Gracias, N. G., Vasko, M. R., & Fehrenbacher, J. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.011 · Cited by 44
Targeting Axon Integrity to Prevent Chemotherapy-Induced Peripheral Neuropathy
Chine, V. B., Au, N. P. B., Kumar, G., & Ma, C. H. E. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1301-8 · Cited by 43
Targeting the CaVα–CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy
Khanna, R., Yu, J., Yang, X.-F., Moutal, A., Chefdeville, A., Gokhale, V. M., Shuja, Z., Chew, L. A., Bellampalli, S. S., Luo, S., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001524 · Cited by 43
Impact of Dose, Sex, and Strain on Oxaliplatin-Induced Peripheral Neuropathy in Mice
Warncke, U. O., Toma, W. B., Meade, J. A., Park, A. J., Thompson, D., Caillaud, M., Bigbee, J. W., Bryant, C. D., & Damaj, M. I. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.683168 · Cited by 42
Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: The role of spinal 5‐HT3 receptors
Costa‐Pereira, J. T., Serrão, P., Martins, I., & Tavares, I. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14614 · Cited by 42
Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy
Kawashiri, T., Egashira, N., Itoh, Y., Shimazoe, T., Ikegami, Y., Yano, T., Yoshimura, M., & Oishi, R. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.004 · Cited by 42
Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats
Kumar, K. K., Priyanka, L., Gnananath, K., Pingili, R. B., & Sujatha, S. (2014) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-014-0203-z · Cited by 41
Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents
Rossato, M. F., Rigo, F. K., Oliveira, S. M., Guerra, G. P., Silva, C. R., Cunha, T. M., Gomez, M. V., Ferreira, J., & Trevisan, G. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.03.033 · Cited by 40
DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain
Brandolini, L., Castelli, V., Aramini, A., Giorgio, C., Bianchini, G., Russo, R., Caro, C. D., d’Angelo, M., Catanesi, M., Benedetti, E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48231-z · Cited by 40
Mesenchymal stem cells therapy enhances the efficacy of pregabalin and prevents its motor impairment in paclitaxel-induced neuropathy in rats: Role of Notch1 receptor and JAK/STAT signaling pathway
Al‐Massri, K. F., Ahmed, L. A., & El-Abhar, H. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.013 · Cited by 38
Neuropathic pain modeling: Focus on synaptic and ion channel mechanisms
Bouali‐Benazzouz, R., Landry, M., Benazzouz, A., & Fossat, P. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102030 · Cited by 40
Role of Spinal Cord α2-Adrenoreceptors in Noradrenergic Inhibition of Nociceptive Transmission During Chemotherapy-Induced Peripheral Neuropathy
Costa‐Pereira, J. T., Ribeiro, J., Martins, I., & Tavares, I. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01413 · Cited by 37
Chronic pain impact on rodents’ behavioral repertoire
Cunha, A. M., Pereira-Mendes, J., Almeida, A., Guimarães, M. R., & Leite‐Almeida, H. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.022 · Cited by 38
Primary culture of trigeminal satellite glial cells: a cell-based platform to study morphology and function of peripheral glia.
Poulsen, J. N., Larsen, F., Duroux, M. C., & Gazerani, P. (2014) · Europe PMC (PubMed Central) · Cited by 37
Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective
Cheng, X. L., Liu, H. Q., Wang, Q., Huo, J. G., Wang, X. N., & Cao, P. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00234 · Cited by 36
Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels
Shan, Z., Cai, S., Yu, J., Zhang, Z., Vallecillo, T., Serafini, M., Thomas, A. M., Pham, N. Y. N., Bellampalli, S. S., Moutal, A., et al. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00166 · Cited by 35
Spinal cord stimulation prevents paclitaxel-induced mechanical and cold hypersensitivity and modulates spinal gene expression in rats
Sivanesan, E., Stephens, K., Huang, Q., Chen, Z., Ford, N. C., Duan, W., He, S.-Q., Gao, X., Linderoth, B., Raja, S. N., et al. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000785 · Cited by 35
Muscle pain in models of chemotherapy‐induced and alcohol‐induced peripheral neuropathy
Álvarez, P., Ferrari, L. F., & Levine, J. D. (2011) · Annals of Neurology · doi:10.1002/ana.22382 · Cited by 34
Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel
Jamieson, S. M. F., Liu, J., Connor, B. J., Dragunow, M., & McKeage, M. J. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.04.009 · Cited by 35
Dorsal root ganglion explants derived from chemotherapy-treated mice have reduced neurite outgrowth in culture
Livni, L., Lees, J. G., Barkl‐Luke, M. E., Goldstein, D., & Moalem‐Taylor, G. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.016 · Cited by 34
Pharmacological interventions targeting Wnt/β-catenin signaling pathway attenuate paclitaxel-induced peripheral neuropathy
Resham, K., & Sharma, S. S. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172714 · Cited by 34
Fatigue and sleep during cancer and chemotherapy: translational rodent models.
Ray, M. A., Rogers, L. Q., Trammell, R. A., & Toth, L. A. (2008) · PubMed Central · Cited by 34
Case Report: Painful Peripheral Neuropathy Following Treatment With Docetaxel for Breast Cancer
Wampler, M. A., Hamolsky, D., Hamel, K. A., Melisko, M., & Topp, K. S. (2005) · Clinical journal of oncology nursing · doi:10.1188/05.cjon.189-193 · Cited by 34

Authors: Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J.
Affiliations: Pennsylvania State University (US)
University of Pennsylvania (US)
Hahnemann University Hospital (US)
Corresponding author: Polomano, Rosemary C.
ORCID: Polomano, Rosemary C.
Mannes, Andrew J.
Clark, Uraina S.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-12
Volume: 94
Issue: 3
Pages: 293-304
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(01)00363-3
OpenAlex: W1991677710
Cited by: 476
References: 79
Citations by year: 2026: 20 · 2025: 10 · 2024: 18 · 2023: 18 · 2022: 16 · 2021: 35 · 2020: 30 · 2019: 27 · 2018: 28 · 2017: 30 · 2016: 18 · 2015: 17 · 2014: 30 · 2013: 21 · 2012: 28
FWCI: 2.62
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
United States Pharmacopeia
National Institutes of Health (5k01nr000136-03)
National Institute of Nursing Research (KO1 NR 00136-01A1)
Topics: Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Keywords: paclitaxel, chemotherapy-induced peripheral neuropathy, neuropathic pain, thermal hyperalgesia, mechanical allodynia, cold allodynia, sciatic nerve, dorsal root ganglia, endoneurial edema, axonal degeneration, rat model, dose-response relationship, length-dependent neuropathy
MeSH terms: Animals, Antineoplastic Agents, Phytogenic, Behavior, Animal, Cold Temperature, Disease Models, Animal, Hot Temperature, Hindlimb, Hyperalgesia, Male, Motor Activity, Peripheral Nervous System Diseases, Physical Stimulation, Tail, Rats, Sprague-Dawley, Paclitaxel, Rats

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A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

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