Changes in sensory processing in the spinal dorsal horn accompany vincristine-induced hyperalgesia and allodynia
Abstract
Abnormal sensation and pain are major dose-limiting factors in cancer chemotherapy with vincristine. In this study, we have adapted a model of this condition by using repeated daily intraperitoneal injections of vincristine in rats. Mechanical allodynia and hyperalgesia without change in responses to thermal stimuli were first observed following 5-8 days of vincristine treatment (0.1mg/kg/day) and then persisted throughout the remainder of the treatment interval (2-3 weeks). Electrophysiological recording from wide dynamic range (WDR) neurons in the lumbar (L4-L5) spinal dorsal horn in hyperalgesic rats demonstrated significantly increased spontaneous activity and after-discharges to noxious mechanical stimuli (von Frey filaments with a bending force greater than 58.02mN, skin compression 1.3 and 3N, 1mm(2)), increased acute A- and C-fiber responses, after-discharges and abnormal 'wind-up' to electrical stimuli (5mA, 2ms) at 0.1Hz applied across the receptive field. These results suggest a state of central sensitization develops in spinal WDR neurons with repeated vincristine treatment that contributes to the spontaneous pain and hyperalgesia seen in patients and the hyperresponsiveness to sensory stimuli seen in animals treated with vincristine.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vincristine produced mechanical allodynia, but not thermal hyperalgesia, in a 10 day injection paradigm.
“Vincristine produced mechanical allodynia, but not thermal hyperalgesia, in a 10 day injection paradigm121.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [121]
Cites
Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108 · see citing works
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works
Chemotherapy-induced peripheral neuropathy
Quasthoff, S., & Hartung, H. P. (2002) · Journal of Neurology · doi:10.1007/pl00007853 · Cited by 967 · see citing works
Mechanism of inhibition of cell proliferation by Vinca alkaloids.
Jordan, M. A., Thrower, D., & Wilson, L. (1991) · PubMed · Cited by 539 · see citing works
Cutaneous sensory receptors in the rat foot
Leem, J. W., Willis, W. D., & Chung, J. M. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.5.1684 · Cited by 410 · see citing works
Kajander, K. C., & Bennett, G. J. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.734 · Cited by 372 · see citing works
Vincristine‐induced neuropathy
Sandier, S. G., Tobin, W. E., & Henderson, E. S. (1969) · Neurology · doi:10.1212/wnl.19.4.367 · Cited by 301 · see citing works
CASEY, E. B., Jelliffe, A. M., Quesne, P. M. L., & Millett, Y. L. (1973) · Brain · doi:10.1093/brain/96.1.69 · Cited by 296 · see citing works
Laird, J. M. A., & Bennett, G. J. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.6.2072 · Cited by 267 · see citing works
Yakhnitsa, V., Linderoth, B., & Meyerson, B. A. (1999) · Pain · doi:10.1016/s0304-3959(98)00169-9 · Cited by 228 · see citing works
Lobert, S., Vulevic, B., & Correia, J. J. (1996) · Biochemistry · doi:10.1021/bi953037i · Cited by 214 · see citing works
Paleček, J., Palečková, V., Dougherty, P. M., Carlton, S. M., & Willis, W. D. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.6.1562 · Cited by 195 · see citing works
Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans
Aley, K. O., Reichling, D. B., & Levine, J. D. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00020-6 · Cited by 185 · see citing works
Long term effects of vincristine on the peripheral nervous system
Postma, T. J., Benard, B. A., Huijgens, P. C., et al. (1993) · Journal of Neuro-Oncology · doi:10.1007/bf01050259 · Cited by 151 · see citing works
Schouenborg, J., Weng, H., Kalliom�ki, J., & Holmberg, H. (1995) · Experimental Brain Research · doi:10.1007/bf00241353 · Cited by 134 · see citing works
Vincristine-induced allodynia in the rat
Nozaki‐Taguchi, N., Chaplan, S. R., Higuera, E. S., Ajakwe, R., & Yaksh, T. L. (2001) · Pain · doi:10.1016/s0304-3959(01)00294-9 · Cited by 126 · see citing works
Nociceptor Hyper-Responsiveness during Vincristine-Induced Painful Peripheral Neuropathy in the Rat
Tanner, K. D., Reichling, D. B., & Levine, J. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06480.1998 · Cited by 119 · see citing works
Pertovaara, A., Kontinen, V., & Kalso, E. A. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6555 · Cited by 111 · see citing works
Laird, J. M. A., & Cerveró, F. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.4.854 · Cited by 108 · see citing works
Domain-restricted expression of two glutamic acid decarboxylase genes in midgestation mouse embryos
Katarova, Z., Sekerkov�, G., Prodan, S., Mugnaini, E., & Szab�, G. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000904)424:4 · Cited by 91 · see citing works
Pain related behaviour during vincristine-induced neuropathy in rats
Authier, N., Coudore, F., Eschalier, A., & Fialip, J. (1999) · NeuroReport · doi:10.1097/00001756-199904060-00013 · Cited by 77 · see citing works
Tabo, E., Jinks, S. L., Eisele, J. H., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00243-7 · Cited by 70 · see citing works
Weiden, P. L., & Wright, S. E. (1972) · New England Journal of Medicine · doi:10.1056/nejm197206222862523 · Cited by 58 · see citing works
Mann, G. (1972) · New England Journal of Medicine · doi:10.1056/nejm197206222862521 · Cited by 56 · see citing works
Peripheral neuropathy in cancer patients: clinical types, etiology, and presentation. Part 2.
Forman, A. (1990) · PubMed · Cited by 34 · see citing works
Zhang, D. X., Owens, C. M., & Willis, W. D. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.65.6.1554 · Cited by 28 · see citing works
Peripheral neuropathy in cancer patients: incidence, features, and pathophysiology.
Forman, A. (1990) · PubMed · Cited by 15 · see citing works
Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4
Flagged first, then by citations
Cited by
Sorted by citations
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
Flatters, S. J. L., & Bennett, G. J. (2004) · Pain · doi:10.1016/j.pain.2004.01.029 · Cited by 576 · see citing works
Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Lynch, M. E., Cesar-Rittenberg, P., & Hohmann, A. G. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.02.018 · Cited by 266 · see citing works
Rahn, E. J., Makriyannis, A., & Hohmann, A. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707333 · Cited by 146 · see citing works
- Authors
- Weng, R. H., Cordella, V. J., & Dougherty, M. P.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Pain
- Published
- 2003-05
- Volume
- 103
- Issue
- 1
- Pages
- 131-138
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W1607354731
- Cited by
- 161
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 15 · 2020: 9 · 2019: 2 · 2018: 11 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 11 · 2013: 12 · 2012: 5
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS039933, NS39933)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- vincristine, mechanical allodynia, dorsal horn, wide dynamic range neurons, central sensitization, afterdischarge, wind-up, spontaneous pain, cancer pain
- MeSH terms
- Action Potentials, Afferent Pathways, Analysis of Variance, Animals, Behavior, Animal, Drug Administration Schedule, Electric Stimulation, Electrophysiology, Hyperalgesia, Male, Pain, Pain Measurement, Physical Stimulation, Reaction Time, Time Factors, Vincristine, Case-Control Studies, Rats, Sprague-Dawley, Posterior Horn Cells, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
