Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats
Open accessAbstract
Background and purpose: The ability of cannabinoids to suppress mechanical hypersensitivity (mechanical allodynia) induced by treatment with the chemotherapeutic agent vincristine was evaluated in rats. Sites of action were subsequently identified. Experimental approach: Mechanical hypersensitivity developed over the course of ten daily injections of vincristine relative to groups receiving saline at the same times. Effects of the CB 1/CB 2 receptor agonist WIN55,212‐2, the receptor‐inactive enantiomer WIN55,212‐3, the CB 2‐selective agonist (R,S)‐AM1241, the opiate agonist morphine and vehicle on chemotherapy‐induced neuropathy were evaluated. WIN55,212‐2 was administered intrathecally (i.t.) or locally in the hindpaw to identify sites of action. Pharmacological specificity was established using competitive antagonists for CB 1 (SR141716) or CB 2 receptors (SR144528). Key results: Systemic administration of WIN55,212‐2, but not WIN55,212‐3, suppressed vincristine‐evoked mechanical allodynia. A leftward shift in the dose‐response curve was observed following WIN55,212‐2 relative to morphine treatment. The CB 1 (SR141716) and CB 2 (SR144528) antagonists blocked the anti‐allodynic effects of WIN55,212‐2. (R,S)‐AM1241 suppressed vincristine‐induced mechanical hypersensitivity through a CB 2 mechanism. Both cannabinoid agonists suppressed vincristine‐induced mechanical hypersensitivity without inducing catalepsy. Spinal sites of action are implicated in cannabinoid modulation of chemotherapy‐induced neuropathy. WIN55,212‐2, but not WIN55,212‐3, administered i.t. suppressed vincristine‐evoked mechanical hypersensitivity at doses that were inactive following local hindpaw administration. Spinal coadministration of both the CB 1 and CB 2 antagonists blocked the anti‐allodynic effects of WIN55,212‐2. Conclusions and implications: Cannabinoids suppress the maintenance of vincristine‐induced mechanical allodynia through activation of CB 1 and CB 2 receptors. These anti‐allodynic effects are mediated, at least in part, at the level of the spinal cord. British Journal of Pharmacology (2007) 152, 765–777; doi:10.1038/sj.bjp.0707333; published online 18 June 2007
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The effects of spinal WIN55,212-2 were blocked by intrathecal co-administration of rimonabant and SR144528, implicating both CB1 and CB2 receptors.
“These effects were blocked by intrathecal co-administration of rimonabant and SR144528, implicating both CB 1 and CB 2 receptors (Rahn et al, 2007).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Rahn et al, 2007
Systemic administration of WIN55,212-2 suppresses vincristine-evoked mechanical allodynia through a CB1 and CB2-dependent mechanism.
“In particular, systemic administration of WIN55,212-2 suppresses vincristine-evoked mechanical allodynia through a CB 1 and CB 2 -dependent mechanism.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Rahn et al, 2007
Spinal administration of WIN55,212-2 suppressed vincristine-evoked mechanical hypersensitivity at doses that were inactive following intraplantar administration.
“Spinal administration of WIN55,212-2 suppressed vincristineevoked mechanical hypersensitivity at doses that were inactive following intraplantar administration.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Rahn et al, 2007
AM1241 reverses vincristine-induced mechanical hypersensitivity through a CB2 receptor mechanism of action.
“In addition, AM1241 reverses vincristine-induced mechanical hypersensitivity through a CB 2 receptor mechanism of action.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Rahn et al, 2007
Mixed CB1/CB2 receptor agonists and CB2 selective receptor agonists reduce nociceptive behavior in vincristine-treated rats.
“Mixed CB 1 /CB 2 receptor agonists and CB 2 selective receptor agonists reduce nociceptive behavior in vincristine-treated rats (Rahn et al, 2007) (see Table 5).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Rahn et al, 2007
Systemic and intrathecal, but not intraplantar, WIN55,212-2 suppressed vincristine-induced mechanical allodynia through activation of CB1 and CB2 receptors.
“Systemic and intrathecal, but not intraplantar, WIN55,212-2 suppressed vincristine-induced mechanical allodynia through activation of CB1 and CB2 receptors.122”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [122]
Systemic (R,S)-AM1241 partially reversed vincristine-induced mechanical allodynia in a CB2-dependent manner.
“Systemic (R,S)-AM1241 also partially reversed vincristine-induced mechanical allodynia in a CB2-dependent manner.122”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [122]
The anti-allodynic effects of WIN55,212-2 and (R,S)-AM1241 were observed at doses that did not produce intrinsic effects on motor behavior in the bar test.
“The anti-allodynic effects of WIN55,212-2 and (R,S)-AM1241 were observed at doses that did not produce intrinsic effects on motor behavior in the bar test.122”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762 · see citing works
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works
Chronic catheterization of the spinal subarachnoid space
Yaksh, T. L., & Rudy, T. A. (1976) · Physiology & Behavior · doi:10.1016/0031-9384(76)90029-9 · Cited by 2,242 · see citing works
Identification and Functional Characterization of Brainstem Cannabinoid CB<sub>2</sub>Receptors
Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., et al. (2005) · Science · doi:10.1126/science.1115740 · Cited by 1,470 · see citing works
Self-citationIncreased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,065 · see citing works
Self-citationCannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.
Mackie, K., & Hille, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3825 · Cited by 693 · see citing works
Mackie, K., Lai, Y. Y., Westenbroek, R. E., & Mitchell, R. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06552.1995 · Cited by 626 · see citing works
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
Flatters, S. J. L., & Bennett, G. J. (2004) · Pain · doi:10.1016/j.pain.2004.01.029 · Cited by 576 · see citing works
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
Hanus, L. O., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R., & Fride, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14228 · Cited by 574 · see citing works
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor
Buckley, N. E., McCoy, K. L., Mezey, É., Bonner, T. I., Zimmer, A. M., Felder, C. C., Glass, M., & Zimmer, A. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00211-9 · Cited by 544 · see citing works
Flatters, S. J. L., & Bennett, G. J. (2006) · Pain · doi:10.1016/j.pain.2006.01.037 · Cited by 536 · see citing works
Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834309100 · Cited by 491 · see citing works
Self-citationA painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00363-3 · Cited by 476 · see citing works
Zhang, J., Hoffert, C., Vu, H. K., Groblewski, T., Ahmad, S., & O'Donnell, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02704.x · Cited by 419 · see citing works
CB2 cannabinoid receptor-mediated peripheral antinociception
Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works
Self-citationFox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works
Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00022-k · Cited by 329 · see citing works
Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13308-5 · Cited by 307 · see citing works
Vincristine‐induced neuropathy
Sandier, S. G., Tobin, W. E., & Henderson, E. S. (1969) · Neurology · doi:10.1212/wnl.19.4.367 · Cited by 301 · see citing works
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms
Beltramo, M., Bernardini, N., Bertorelli, R., Campanella, M., Nicolussi, E., Fredduzzi, S., & Reggiani, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04684.x · Cited by 290 · see citing works
Porreca, F., Burgess, S. E., Gardell, L. R., Vanderah, T. W., Malan, T. P., Ossipov, M. H., Lappi, D. A., & Lai, J. Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05281.2001 · Cited by 266 · see citing works
Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., & Winter, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.009 · Cited by 251 · see citing works
Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors
Quartilho, A., Mata, H. P., Ibrahim, M. M., Vanderah, T. W., Porreca, F., Makriyannis, A., & Malan, T. P. (2003) · Anesthesiology · doi:10.1097/00000542-200310000-00031 · Cited by 243 · see citing works
Self-citationBridges, D., Ahmad, K., & Rice, A. S. C. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704110 · Cited by 221 · see citing works
Dysregulation of Cellular Calcium Homeostasis in Chemotherapy-Evoked Painful Peripheral Neuropathy
Siau, C., & Bennett, G. J. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000204318.35194.ed · Cited by 185 · see citing works
Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord
Hohmann, A. G., Briley, E. M., & Herkenham, M. A. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01321-3 · Cited by 183 · see citing works
Self-citationNackley, A. G., Makriyannis, A., & Hohmann, A. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00126-x · Cited by 176 · see citing works
Self-citationMartin, W. J., Hohmann, A. G., & Walker, J. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06601.1996 · Cited by 172 · see citing works
Self-citationCB2 cannabinoid receptor mediation of antinociception
Ibrahim, M. M., Rude, M. L., Stagg, N. J., Mata, H. P., Lai, J. Y., Vanderah, T. W., Porreca, F., Buckley, N. E., Makriyannis, A., & Malan, P. T. (2006) · Pain · doi:10.1016/j.pain.2005.12.018 · Cited by 172 · see citing works
Self-citationDescription of a short-term Taxol®-induced nociceptive neuropathy in rats
Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudore, F. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02910-3 · Cited by 171 · see citing works
Cata, J. P., Weng, H., Lee, B., Reuben, J. M., & Dougherty, P. M. (2006) · PubMed · Cited by 171 · see citing works
An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections
Authier, N. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00003-7 · Cited by 165 · see citing works
Weng, R. H., Cordella, V. J., & Dougherty, M. P. (2003) · Pain · doi:10.1016/s0304-3959(02)00445-1 · Cited by 161 · see citing works
Selective Opioid Inhibition of Small Nociceptive Neurons
Taddese, A., Nah, S.-Y., & McCleskey, E. W. (1995) · Science · doi:10.1126/science.270.5240.1366 · Cited by 161 · see citing works
Sagar, D. R., Kelly, S., Millns, P. J., O'Shaughnessey, C. T., Kendall, D. A., & Chapman, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04206.x · Cited by 154 · see citing works
Vera–Portocarrero, L. P., Zhang, E.-T., Ossipov, M. H., Xie, J. Y., King, T. E., Lai, J., & Porreca, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.016 · Cited by 141 · see citing works
Walczak, J.-S., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.010 · Cited by 133 · see citing works
Whiteside, G. T., Lee, G. P., & Valenzano, K. J. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780363023 · Cited by 132 · see citing works
Kawamata, M., & Omote, K. (1996) · Pain · doi:10.1016/s0304-3959(96)03222-8 · Cited by 131 · see citing works
Vincristine-induced allodynia in the rat
Nozaki‐Taguchi, N., Chaplan, S. R., Higuera, E. S., Ajakwe, R., & Yaksh, T. L. (2001) · Pain · doi:10.1016/s0304-3959(01)00294-9 · Cited by 126 · see citing works
Hohmann, A. G., Farthing, J. N., Zvonok, A. M., & Makriyannis, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060079 · Cited by 123 · see citing works
Self-citationLynch, J. J., Wade, C. L., Zhong, C., Mikusa, J. P., & Honoré, P. (2004) · Pain · doi:10.1016/j.pain.2004.03.010 · Cited by 122 · see citing works
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats
Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I. (2005) · Pain · doi:10.1016/j.pain.2005.07.008 · Cited by 117 · see citing works
Kehl, L. J., Hamamoto, D. T., Wacnik, P. W., Croft, D. L., Norsted, B. D., Wilcox, G. L., & Simone, D. A. (2003) · Pain · doi:10.1016/s0304-3959(02)00450-5 · Cited by 115 · see citing works
Nackley, A. G., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00886.2003 · Cited by 111 · see citing works
Self-citationAley, K. O., & Levine, J. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00009-x · Cited by 110 · see citing works
A New Animal Model of Vincristine-Induced Nociceptive Peripheral Neuropathy
Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudoré, F. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(03)00043-3 · Cited by 110 · see citing works
Selective Mediation of Nerve Injury-Induced Tactile Hypersensitivity by Neuropeptide Y
Ossipov, M. H., Zhang, E.-T., Carvajal, C., Gardell, L. R., Quirion, R., Dumont, Y., Lai, J. Y., & Porreca, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09858.2002 · Cited by 109 · see citing works
LaBuda, C. J., & Little, P. J. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.11.008 · Cited by 108 · see citing works
Hohmann, A. G., Tsou, K., & Walker, J. M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00802-7 · Cited by 108 · see citing works
Self-citationCata, J. P., Weng, H., Chen, J.-H., & Dougherty, P. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.009 · Cited by 108 · see citing works
Two distinctive antinociceptive systems in rats with pathological pain
Mao, J., Price, D. D., Lü, J., Keniston, L., & Mayer, D. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00998-2 · Cited by 104 · see citing works
Amelioration of vincristine neurotoxicity by glutamic acid
Jackson, D. V., Wells, H. B., Atkins, J. N., Zekan, P. J., White, D. R., Richards, F., Cruz, J. M., & Muss, H. B. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90306-3 · Cited by 102 · see citing works
Hohmann, A. G., & Herkenham, M. A. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00534-5 · Cited by 102 · see citing works
Self-citationJoshi, S. K., Hernandez, G., Mikusa, J. P., Zhu, C. Z., Zhong, C., Salyers, A. K., Wismer, C. T., Chandran, P., Decker, M. W., & Honoré, P. H. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.005 · Cited by 100 · see citing works
Chemotherapy-evoked Painful Peripheral Neuropathy
Polomano, R. C., & Bennett, G. J. (2001) · Pain Medicine · doi:10.1046/j.1526-4637.2001.002001008.x · Cited by 100 · see citing works
Domain-restricted expression of two glutamic acid decarboxylase genes in midgestation mouse embryos
Katarova, Z., Sekerkov�, G., Prodan, S., Mugnaini, E., & Szab�, G. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000904)424:4 · Cited by 91 · see citing works
Drew, L., Harris, J. E., Millns, P. J., Kendall, D. A., & Chapman, V. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00101.x · Cited by 82 · see citing works
Strangman, N. M., & Walker, J. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.472 · Cited by 81 · see citing works
Pertwee, R. G., & Ross, T. M. (1991) · Neuropharmacology · doi:10.1016/0028-3908(91)90044-c · Cited by 79 · see citing works
Pain related behaviour during vincristine-induced neuropathy in rats
Authier, N., Coudore, F., Eschalier, A., & Fialip, J. (1999) · NeuroReport · doi:10.1097/00001756-199904060-00013 · Cited by 77 · see citing works
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats
Ulugöl, A., Karadağ, Ç. H., İpçi, Y., Tamer, M., & Dökmeci, İ. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.061 · Cited by 73 · see citing works
Kamei, J., Tamura, N., & Saitoh, A. (2005) · Pain · doi:10.1016/j.pain.2005.05.026 · Cited by 46 · see citing works
Özçay, F., Kayıran, S. M., & Özbek, N. Y. (2003) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2003.2897 · Cited by 14 · see citing works
Bacon, M. A., James, K., & Zee, B. C.-Y. (2003) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.2003.13320.x · Cited by 11 · see citing works
A cannabinoid pharmacotherapy for chemotherapy-evoked painful peripheral neuropathy
Hohmann, A. G. (2005) · Pain · doi:10.1016/j.pain.2005.07.007 · Cited by 10 · see citing works
Self-citationDrug-Induced Gastrointestinal Disorders
Hyson, E. A., Burrell, M. I., & Toffler, R. B. (1981) · Radiology of iatrogenic disorders · doi:10.1007/978-1-4612-5853-7_1 · Cited by 5 · see citing works
Drug-induced Gastrointestinal Disorders
Hawkey, C. J., & Skelly, M. M. (2003) · Medicine · doi:10.1383/medc.31.3.106.28498 · Cited by 2 · see citing works
Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4
Flagged first, then by citations
Cited by
Sorted by citations
Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works
Self-citationCannabinoids and Pain: New Insights From Old Molecules
Vuckovic, S. M., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01259 · Cited by 417 · see citing works
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Self-citationDonvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Cannabinoids in the management of difficult to treat pain
Russo, E. B. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1928 · Cited by 296 · see citing works
Ward, S. J., McAllister, S. D., Kawamura, R., Murase, R., Neelakantan, H., & Walker, E. A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12439 · Cited by 277 · see citing works
Lynch, M. E., Cesar-Rittenberg, P., & Hohmann, A. G. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.02.018 · Cited by 266 · see citing works
Self-citationCytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management
Vanderwall, A. G., & Milligan, E. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03009 · Cited by 219 · see citing works
Deng, L., Guindon, J., Cornett, B., Makriyannis, A., Mackie, K., & Hohmann, A. G. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.009 · Cited by 200 · see citing works
Self-citationThe Role of the Endocannabinoid System in Pain
Woodhams, S. G., Sagar, D. R., Burston, J. J., & Chapman, V. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-46450-2_7 · Cited by 205 · see citing works
Sciolino, N. R., Zhou, W., & Hohmann, A. G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.010 · Cited by 179 · see citing works
Self-citationKinsey, S. G., Wise, L. E., Ramesh, D., Abdullah, R., Selley, D. E., Cravatt, B. F., & Lichtman, A. H. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201426 · Cited by 169 · see citing works
Guindon, J., Lai, Y., Takacs, S. M., Bradshaw, H. B., & Hohmann, A. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.013 · Cited by 160 · see citing works
Self-citationKing, K. M., Myers, A. M., Soroka‐Monzo, A. J., Tuma, R. F., Tallarida, R. J., Walker, E. A., & Ward, S. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13887 · Cited by 156 · see citing works
The analgesic potential of cannabinoids.
Elikottil, M., Gupta, M., & Gupta, P. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0034 · Cited by 141 · see citing works
Animal Models of Chemotherapy-Evoked Painful Peripheral Neuropathies
Authier, N., Balayssac, D., Marchand, F., Ling, B., Zangarelli, A., Descoeur, J., Coudoré, F., Bourinet, E., & Eschalier, A. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.003 · Cited by 120 · see citing works
Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116 · see citing works
Self-citationCB1 Cannabinoid Receptor Signaling and Biased Signaling
Leo, L. M., & Abood, M. E. (2021) · Molecules · doi:10.3390/molecules26175413 · Cited by 117 · see citing works
Integrating Cannabis into Clinical Cancer Care
Abrams, D. I. (2016) · Current Oncology · doi:10.3747/co.23.3099 · Cited by 115 · see citing works
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice
Segat, G. C., Manjavachi, M. N., Matias, D. O., Passos, G. F., Freitas, C. S., da Costa, R., & Calixto, J. Β. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.015 · Cited by 113 · see citing works
Deng, L., Guindon, J., Vemuri, V. K., Thakur, G. A., White, F. A., Makriyannis, A., & Hohmann, A. G. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-71 · Cited by 94 · see citing works
Self-citationOpportunities for cannabis in supportive care in cancer
Kleckner, A., Kleckner, I., Kamen, C., Tejani, M., Janelsins, M., Morrow, G., & Peppone, L. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919866362 · Cited by 78 · see citing works
Lal, S., Shekher, A., Puneet, Narula, A. S., Abrahamse, H., & Gupta, S. C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105302 · Cited by 89 · see citing works
Naguib, M., Diaz, P., Xu, J. J., Astruc‐Diaz, F., Craig, S., Vivas‐Mejia, P., & Brown, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.340 · Cited by 82 · see citing works
Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands
Davis, M. P. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.918603 · Cited by 79 · see citing works
Dynamic changes to the endocannabinoid system in models of chronic pain
Sagar, D. R., Burston, J. J., Woodhams, S. G., & Chapman, V. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0390 · Cited by 76 · see citing works
Opioid and cannabinoid synergy in a mouse neuropathic pain model
Kazantzis, N. P., Casey, S. L., Seow, P. W., Mitchell, V. A., & Vaughan, C. W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13534 · Cited by 71 · see citing works
Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain
Gutierrez, T., Crystal, J. D., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pain · doi:10.1016/j.pain.2011.03.038 · Cited by 71 · see citing works
Self-citationCannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain
Blanton, H. L., Brelsfoard, J., Deturk, N., Pruitt, K., Narasimhan, M., Morgan, D. J., & Guindon, J. (2019) · Drugs · doi:10.1007/s40265-019-01132-x · Cited by 70 · see citing works
Chapter 14 Involvement of Inflammatory Mediators in Neuropathic Pain Caused by Vincristine
Kiguchi, N., Maeda, T., Kobayashi, Y., Saika, F., & Kishioka, S. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85014-9 · Cited by 70 · see citing works
Use of Cannabis and Cannabinoids for Treatment of Cancer
Cherkasova, V., Wang, B., Gerasymchuk, M., Fiselier, A., Kovalchuk, O., & Kovalchuk, I. (2022) · Cancers · doi:10.3390/cancers14205142 · Cited by 70 · see citing works
Vera, G., Cabezos, P. A., Martín, M. I., & Abalo, R. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.02.008 · Cited by 68 · see citing works
Ling, B., Coudoré, F., Decalonne, L., Eschalier, A., & Authier, N. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.007 · Cited by 67 · see citing works
Gamaleddin, I., Zvonok, A. M., Makriyannis, A., Goldberg, S. R., & Foll, B. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029900 · Cited by 66 · see citing works
Self-citationRahn, E. J., Deng, L., Thakur, G. A., Vemuri, K. V., Zvonok, A. M., Lai, Y. Y., Makriyannis, A., & Hohmann, A. G. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-27 · Cited by 65 · see citing works
Self-citationMulpuri, Y., Marty, V. N., Munier, J. J., Mackie, K., Schmidt, B. L., Seltzman, H. H., & Spigelman, I. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.002 · Cited by 62 · see citing works
Role of Cannabinoids in Pain Management
Russo, E. B., & Hohmann, A. G. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1560-2_18 · Cited by 62 · see citing works
Self-citationMakriyannis, A. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500220s · Cited by 61 · see citing works
Self-citationCannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
Campos, R. M. P., Aguiar, A. F. L., Paes-Colli, Y., Trindade, P. M. P., Ferreira, B. K., Reis, R. A. D. M., & Sampaio, L. D. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.785176 · Cited by 59 · see citing works
Cannabis, Cannabinoids and Cannabis-Based Medicines in Cancer Care
Abrams, D. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354221081772 · Cited by 49 · see citing works
Rahn, E. J., Thakur, G. A., Wood, J. A. T., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.024 · Cited by 57 · see citing works
Self-citationRole of the endogenous cannabinoid system in nicotine addiction: novel insights
Gamaleddin, I. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00041 · Cited by 58 · see citing works
The pharmacological management of dental pain
Pergolizzi, J. V., Magnusson, P., LeQuang, J. A., Gharibo, C. G., & Varrassi, G. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1718651 · Cited by 53 · see citing works
Wilkerson, J. L., Gentry, K. R., Dengler, E. C., Wallace, J. A., Kerwin, A. A., Kuhn, M. N., Zvonok, A. M., Thakur, G. A., Makriyannis, A., & Milligan, E. D. (2012) · Brain and Behavior · doi:10.1002/brb3.44 · Cited by 51 · see citing works
Self-citationThe central cannabinoid receptor type-2 (CB2) and chronic pain
Shang, Y.-C., & Tang, Y. (2016) · International Journal of Neuroscience · doi:10.1080/00207454.2016.1257992 · Cited by 51 · see citing works
Hossain, M. Z., Ando, H., Unno, S., & Kitagawa, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041423 · Cited by 52 · see citing works
Wala, E. P., Crooks, P. A., McIntosh, J. M., & Holtman, J. R. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31825a3c72 · Cited by 43 · see citing works
Effect of Chronic Pain on Fentanyl Self-Administration in Mice
Wade, C. L., Krumenacher, P., Kitto, K. F., Peterson, C. D., Wilcox, G. L., & Fairbanks, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079239 · Cited by 43 · see citing works
Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-Induced Neuropathic Pain in Rodents
Kalvala, A. K., Bagde, A., Arthur, P., Surapaneni, S. K., Nimma, R., Nathani, A., & Singh, M. S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108693 · Cited by 43 · see citing works
Reddy, V. P., Grogan, D. P., Ahluwalia, M., Salles, É. L., Ahluwalia, P. K., Khodadadi, H., Alverson, K., Nguyen, A., Raju, S. P., Gaur, P., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00203-4 · Cited by 42 · see citing works
Microglial Cannabinoid CB2 Receptors in Pain Modulation
Xu, K., Wu, Y., Tian, Z., Xu, Y., Wu, C., & Wang, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032348 · Cited by 41 · see citing works
Vera, G., López‐Miranda, V., Herradón, E., Martı́n, M. I., & Abalo, R. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.05.008 · Cited by 41 · see citing works
Role of sensory nerves in gastroprotective effect of anandamide in rats.
Warzecha, Z., DEMBINSKI, A. B., Ceranowicz, P., Dembiński, M., Cieszkowski, J., Kownacki, P., & Konturek, P. C. (2011) · PubMed · Cited by 41 · see citing works
Park, B. Y., Park, S. H., Kim, W. M., Yoon, M. H., & Lee, H. G. (2010) · The Korean journal of pain · doi:10.3344/kjp.2010.23.3.179 · Cited by 39 · see citing works
Masocha, W. (2018) · Pain Research and Management · doi:10.1155/2018/5234943 · Cited by 37 · see citing works
Cannabis for Pain and Headaches: Primer
Kim, P. S., & Fishman, M. A. (2017) · Current Pain and Headache Reports · doi:10.1007/s11916-017-0619-7 · Cited by 36 · see citing works
Furuse, S., Kawamata, T., Yamamoto, J., Niiyama, Y., Omote, K., Watanabe, M., & Namiki, A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181a51e0d · Cited by 37 · see citing works
Ghovanloo, M., Estación, M., Higerd‐Rusli, G. P., Zhao, P., Dib‐Hajj, S. D., & Waxman, S. G. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15833 · Cited by 33 · see citing works
Wu, B.-Y., Liu, C., Su, Y., Chen, S., Chen, Y., & Tsai, M.-Y. (2018) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.11.022 · Cited by 33 · see citing works
Repetti, C. S. F., Gírio, R. J. S., Friolani, M., & Barbalho, S. M. (2019) · Ciência Rural · doi:10.1590/0103-8478cr20180595 · Cited by 38 · see citing works
Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia
Mishra, G., Singh, P. N. D., Molla, M., Yimer, Y. S., Ewunetie, A., Tadesse, T. Y., Ayele, T. M., & Kefale, B. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105260 · Cited by 32 · see citing works
Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy
Tamba, B.-I., Stanciu, G. D., Urîtu, C. M., Rezuş, E., Ştefănescu, R., Mihai, C. T., Luca, A., Rusu-Zota, G., Leon, M. M., Cojocaru, E., et al. (2020) · Medicina · doi:10.3390/medicina56010024 · Cited by 32 · see citing works
Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice
Linglu, D., Li, Y., Xu, Y., Ru, Z., Ma, L., Shaoju, J., Du, J., Sun, T., & Yu, J. (2013) · Neurological Sciences · doi:10.1007/s10072-013-1603-6 · Cited by 31 · see citing works
Thomas, A., Okine, B. N., Finn, D. P., & Masocha, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110456 · Cited by 29 · see citing works
Bhalla, S., Singh, N., & Jaggi, A. S. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.02.016 · Cited by 29 · see citing works
Henderson, A. N., Crawford, L. C., Sepúlveda, D. E., Hale, D. E., Lesperance, J., & Morgan, D. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.684115 · Cited by 30 · see citing works
Łuszczki, J. J., & Florek-Łuszczki, M. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70867-8 · Cited by 28 · see citing works
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system
Cabañero, D., Martín‐García, E., & Maldonado, R. J. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1971196 · Cited by 29 · see citing works
Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat
Abalo, R., Cabezos, P. A., Vera, G., López-Pérez, A. E., & Martı́n, M. I. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12073 · Cited by 28 · see citing works
Abalo, R., Chen, C., Vera, G., Fichna, J., Thakur, G. A., López-Pérez, A. E., Makriyannis, A., Martı́n, M. I., & Storr, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12668 · Cited by 28 · see citing works
Self-citationTopical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
D’Andre, S. D., McAllister, S. D., Nagi, J., Giridhar, K. V., Ruiz-Macias, E., & Loprinzi, C. L. (2021) · Integrative Cancer Therapies · doi:10.1177/15347354211061739 · Cited by 27 · see citing works
Should Oncologists Recommend Cannabis?
Abrams, D. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0659-9 · Cited by 22 · see citing works
Casey, S. L., Mitchell, V. A., Sokolaj, E. E., Winters, B. L., & Vaughan, C. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158649 · Cited by 26 · see citing works
Sadaka, A. H., Canuel, J., Febo, M., Johnson, C. T., Bradshaw, H. B., Ortiz, R. J., Ciumo, F., Kulkarni, P., Gitcho, M. A., & Ferris, C. F. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1055433 · Cited by 25 · see citing works
Abalo, R., Cabezos, P. A., Vera, G., Fernández‐pujol, R., & Martı́n, M. I. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01466.x · Cited by 26 · see citing works
Alkislar, I., Miller, A. R., Hohmann, A. G., Sadaka, A. H., Cai, X., Kulkarni, P., & Ferris, C. F. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.11.015 · Cited by 24 · see citing works
Self-citationAlmaraz, E. R., & Butowski, N. A. (2023) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-01047-y · Cited by 24 · see citing works
Herbal medicines and chemotherapy induced peripheral neuropathy (CIPN): A critical literature review
Schloss, J. M., Colosimo, M. L., & Vitetta, L. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.889081 · Cited by 23 · see citing works
Update on cannabis and cannabinoids for cancer pain
Chung, M. J., Kim, H. K., & Abdi, S. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000934 · Cited by 24 · see citing works
Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition
Kawamata, T., Niiyama, Y., Yamamoto, J., & Furuse, S. (2010) · Journal of Anesthesia · doi:10.1007/s00540-010-0919-0 · Cited by 22 · see citing works
Slivicki, R. A., Ali, Y., Lu, H., & Hohmann, A. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147620 · Cited by 21 · see citing works
Self-citationOstadhadi, S., Rahmatollahi, M., Dehpour, A. R., & Rahimian, R. (2014) · Phytotherapy Research · doi:10.1002/ptr.5265 · Cited by 19 · see citing works
Chronic pain and cannabinoids. Great expectations or a christmas carol
Pascual, D., Sánchez-Robles, E., García, M. M., & Goicoechea, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.033 · Cited by 22 · see citing works
Lee, G., & Kim, S. K. (2016) · Molecules · doi:10.3390/molecules21091252 · Cited by 21 · see citing works
Arena, C., Gado, F., Mannelli, L. D. C., Cervetto, C., Carpi, S., Reynoso-Moreno, I., Polini, B., Vallini, E., Chicca, S., Lucarini, E., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112858 · Cited by 20 · see citing works
Bagüés, A., López‐Tofiño, Y., Llorente‐Berzal, A., & Abalo, R. (2022) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000667 · Cited by 18 · see citing works
Goel, Y., Fouda, R., & Gupta, K. (2022) · Antioxidants · doi:10.3390/antiox11020265 · Cited by 19 · see citing works
Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence
Safi, K., Sobieraj, J., Błaszkiewicz, M., Żyła, J., Salata, B., & Dzierżanowski, T. (2024) · Biomedicines · doi:10.3390/biomedicines12020307 · Cited by 21 · see citing works
Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain
Małek, N., Kucharczyk, M. W., & Starowicz, K. (2014) · BioMed Research International · doi:10.1155/2014/686908 · Cited by 19 · see citing works
Spyridakos, D., Papadogkonaki, S., Dionysopoulou, S., Mastrodimou, N., Polioudaki, H., & Thermos, K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104907 · Cited by 17 · see citing works
Do cannabinoids have a role in cancer pain management?
Farquhar-Smith, W. P. (2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283260612 · Cited by 15 · see citing works
Kim, K., Jeong, W., Jun, I., & Park, J. Y. (2020) · Korean Journal of Anesthesiology · doi:10.4097/kja.19481 · Cited by 15 · see citing works
Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence
Sokolaj, E. E., Assareh, N., Anderson, K. E., Aubrey, K. R., & Vaughan, C. W. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15964 · Cited by 15 · see citing works
Suppressive Effect of Imipramine on Vincristine-Induced Mechanical Allodynia in Mice
Saika, F., Kiguchi, N., Kobayashi, Y., Fukazawa, Y., Maeda, T., Ozaki, M., & Kishioka, S. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1231 · Cited by 14 · see citing works
Ghovanloo, M.-R., Effraim, P. R., Tyagi, S., Zhao, P., Dib-Hajj, S., & Waxman, S. (2024) · Communications Biology · doi:10.1038/s42003-024-05781-x · Cited by 15 · see citing works
The Efficacy of Cannabis in Oncology Patient Care and Its Anti-Tumor Effects
Shalata, W., Saleh, O. A., Tourkey, L., Shalata, S., Neime, A. E., Abu‐Juma, A., Soklakova, A., Tourkey, L., Jama, A. A., & Yakobson, A. (2024) · Cancers · doi:10.3390/cancers16162909 · Cited by 13 · see citing works
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
Guenther, K. G., & Hohmann, A. G. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70116 · Cited by 12 · see citing works
Self-citationEmerging Roles of Cannabinoids and Synthetic Cannabinoids in Clinical Experimental Models
Morales, P., & Reggio, P. H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-57369-0_4 · Cited by 13 · see citing works
Gorzo, A., Havasi, A. D., Spînu, Ș., Oprea, A. L., Burz, C. C., & Sur, D. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175036 · Cited by 13 · see citing works
Pros and Cons of the Cannabinoid System in Cancer: Focus on Hematological Malignancies
Irrera, N., Bitto, A., Sant’Antonio, E., Lauro, R., Musolino, C., & Allegra, A. (2021) · Molecules · doi:10.3390/molecules26133866 · Cited by 12 · see citing works
- Authors
- Rahn, E. J., Makriyannis, A., & Hohmann, A. G.
- Affiliations
- University of Georgia (US)
- Northeastern University (US)
- Corresponding author
- Hohmann, A G
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2007-11
- Volume
- 152
- Issue
- 5
- Pages
- 765-777
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC2190028
- OpenAlex
- W1542530495
- Cited by
- 146
- References
- 70
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 10 · 2012: 11
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Psi Chi
- American Psychological Association of Graduate Students
- National Institute on Drug Abuse (DA3801, DA022478, DA 9158, R01DA003801, R21DA022478, R01DA021644, R01DA014022, R37DA003801, DA014022, P01DA009158, DA021644)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- CB1 receptor, CB2 receptor, vincristine, chemotherapy-induced peripheral neuropathy, mechanical allodynia, neuropathic pain, WIN 55,212-2, SR141716, SR144528, morphine, spinal cord, intrathecal administration
- MeSH terms
- Rimonabant, Animals, Body Weight, Camphanes, Cannabinoids, Catalepsy, Dose-Response Relationship, Drug, Hindlimb, Hyperesthesia, Injections, Intraperitoneal, Injections, Spinal, Male, Morphine, Morpholines, Naphthalenes, Neuralgia, Pain Measurement, Physical Stimulation, Piperidines, Pyrazoles, Thermosensing, Vincristine, Rats, Sprague-Dawley, Pain Threshold, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Benzoxazines, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
