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Cited by 174Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control

Carbó, Neus, López-Soriano, Joaquı́n, Costelli, Paola, Alvarez, Belén, Busquets, Sı́lvia, Baccino, Francesco M, Quinn, LeBris S, López-Soriano, Francisco J, Argilés, Josep M·2001·Biochimica et Biophysica Acta (BBA) - General Subjects
DOI 10.1016/s0304-4165(00)00188-4
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Abstract

Interleukin (IL)-15 is a cytokine which is highly expressed in skeletal muscle. Cell culture studies have indicated that IL-15 may have an important role in muscle fiber growth and anabolism. However, data concerning the metabolic effects of this cytokine in vivo are lacking. In the present study, IL-15 was administered to adult rats for 7 days. While IL-15 did not cause changes in either muscle mass or muscle protein content, it induced significant changes in the fractional rates of both muscle protein synthesis and degradation, with no net changes in protein accumulation. Additionally, IL-15 administration resulted in a 33% decrease in white adipose tissue mass and a 20% decrease in circulating triacylglycerols; this was associated with a 47% lower hepatic lipogenic rate and a 36% lower plasma VLDL triacylglycerol content. The decrease in white fat induced by IL-15 was in adipose tissue. No changes were observed in the rate of lipolysis as a result of cytokine administration. These findings indicate that IL-15 has significant effects on both protein and lipid metabolism, and suggest that this cytokine may participate in reciprocal regulation of muscle and adipose tissue mass.

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Crossref · 10.1016/s0304-4165(00)00188-4

Cites

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Citations

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Research works printed but not linked: 4

  1. M.W. Slein, d-Glucose determination with hexokinase and glucose-6-phosphate dehydrogenase, in: H.U. Bergmeyer (Ed.), Methods of Enzymatic Analysis, Academic Press, New York, 1963, pp. 117–123.
  2. Nilsson-Ehle, 1977, Rapid, simple and specific assays for lipoprotein lipase and hepatic lipase, Artery, 3, 197
  3. J.D. Lee, T.D. Lee, in: Statistic and Numerical Methods for Biologists, vol. 1, Van Nostrand Reinhold Company, 1982, pp. 185–205.
  4. D.H. Williamson, Regulation of adipose tissue mass and metabolism, in: N.J. Rothwell, M.J. Stock (Eds.), Obesity and Cachexia, John Wiley and Sons, New York, 1991, pp. 63–101.

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Metadata

Authors
Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F. M., Quinn, L. S., López-Soriano, F. J., & Argilés, J. M.
Affiliations
  • Universitat de Barcelona (ES)
  • University of Turin (IT)
  • University of Washington (US)
Corresponding author
Argilés, Josep M
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2001-04
Volume
1526
Issue
1
Pages
17-24
ISSN
0304-4165 (ISSN-L)
DOI
10.1016/s0304-4165(00)00188-4
OpenAlex
W2040190888
Cited by
174
References
42
Citations by year
2024: 7 · 2023: 6 · 2022: 11 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 7
FWCI
2.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
IL-15, white adipose tissue, skeletal muscle mass, weight management, muscle protein synthesis, muscle protein degradation, hepatic lipogenesis, triglyceride metabolism, lipolysis
MeSH terms
Adipose Tissue, Animals, Body Weight, Eating, Lipolysis, Lipoproteins, VLDL, Male, Muscle Proteins, Organ Size, Triglycerides, Rats, Wistar, Muscle, Skeletal, Interleukin-15, Rats

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