Asparagine-linked glycosylation in the yeast Golgi

Dean, Neta

doi:10.1016/s0304-4165(98)00132-9

Cited by 188Glycosylation and Glycoproteins ResearchFungal and yeast genetics researchCellular transport and secretion

Asparagine-linked glycosylation in the yeast Golgi

Dean, Neta·1999·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/s0304-4165(98)00132-9

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Abstract

The Golgi complex is the site where the terminal carbohydrate modification of proteins and lipids occurs. These carbohydrates play a variety of biological roles, ranging from the stabilization of glycoprotein structure to the provision of ligands for cell-cell interactions to the regulation of cell surface properties. Progress in our understanding of the biosynthesis and regulation of glycoconjugates has been accelerating at a rapid pace. Recent advances in the field of yeast glycobiology have been particularly impressive. This review focuses on glycosylation of proteins in the Golgi of the yeast Saccharomyces cerevisiae, with emphasis on the candidate mannosyltransferases that participate in the synthesis of N-linked oligosaccharides. Current views on how these enzymes may be regulated and how glycosylation relates on other cellular processes are also discussed.

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Yeast cells produce glycoproteins with high-mannose glycan structures, which may be immunogenic and less potent in humans.
“However, these cells produce glycoproteins with high-mannose glycans structures, which may be immunogenic and less potent in humans (Dean, 1999;Gemmill and Trimble, 1999;Gerngross, 2004;Dumont et al., 2015).”
From Therapeutic glycoprotein production in mammalian cells (2017) · cites this paper as Dean, 1999

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Dynamics of cell wall structure in Saccharomyces cerevisiae
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Htm1p, a mannosidase‐like protein, is involved in glycoprotein degradation in yeast
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Outer Chain N-Glycans Are Required for Cell Wall Integrity and Virulence of Candida albicans
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Mnt1p and Mnt2p of Candida albicans Are Partially Redundant α-1,2-Mannosyltransferases That Participate in O-Linked Mannosylation and Are Required for Adhesion and Virulence
Munro, C. A., Bates, S., Buurman, E. T., Hughes, H. B., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Bain, J. M., Brand, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411413200 · Cited by 200 · see citing works
Candida albicans Pmr1p, a Secretory Pathway P-type Ca2+/Mn2+-ATPase, Is Required for Glycosylation and Virulence
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Golgi Localization of Glycosyltransferases Requires a Vps74p Oligomer
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In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans inPichia pastoris
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Quo vadis? The challenges of recombinant protein folding and secretion in Pichia pastoris
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N -Glycosylation of Effector Proteins by an α-1,3-Mannosyltransferase Is Required for the Rice Blast Fungus to Evade Host Innate Immunity
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A eukaryotic capsular polysaccharide is synthesized intracellularly and secreted via exocytosis.
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Appropriate Glycosylation of Recombinant Proteins for Human Use: Implications of Choice of Expression System
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Surface Glycans ofCandida albicansand Other Pathogenic Fungi: Physiological Roles, Clinical Uses, and Experimental Challenges
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Engineering of glycosylation in yeast and other fungi: current state and perspectives
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Engineering of an artificial glycosylation pathway blocked in core oligosaccharide assembly in the yeast Pichia pastoris: production of complex humanized glycoproteins with terminal galactose
Bobrowicz, P. (2004) · Glycobiology · doi:10.1093/glycob/cwh104 · Cited by 150 · see citing works
Endoplasmic Reticulum α-Glycosidases of Candida albicans Are Required for N Glycosylation, Cell Wall Integrity, and Normal Host-Fungus Interaction
Mora-Montes, H. M., Bates, S., Netea, M. G., Díaz-Jiménez, D. F., López-Romero, E., Zinker, S., Ponce‐Noyola, P., Kullberg, B. J., Brown, A. J. P., Odds, F. C., et al. (2007) · Eukaryotic Cell · doi:10.1128/ec.00350-07 · Cited by 149 · see citing works
Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network
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Specific molecular features in the organization and biosynthesis of the cell wall ofAspergillus fumigatus
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Localization of Golgi-resident glycosyltransferases
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Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate
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Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up
Madhavan, A., Arun, K. B., Sindhu, R., Krishnamoorthy, J., Rajasekharan, R., Sirohi, R., Pugazhendi, A., Awasthi, M. K., Szakács, G., & Binod, P. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01617-z · Cited by 117 · see citing works
Mechanisms of transport through the Golgi complex
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What can yeast tell us about N‐linked glycosylation in the Golgi apparatus?
Munro, S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02488-7 · Cited by 115 · see citing works
Targeted metabolic labeling of yeast N-glycans with unnatural sugars
Breidenbach, M. A., Gallagher, J. E. G., King, D., Smart, B. P., Wu, P., & Bertozzi, C. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911247107 · Cited by 100 · see citing works
Galactomannoproteins of Aspergillus fumigatus
Morelle, W., Bernard, M., Debeaupuis, J.-P., Buitrago, M., Tabouret, M., & Latgé, J.-P. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.7.1308-1316.2005 · Cited by 98 · see citing works
Identification of a New Family of Genes Involved in β-1,2-Mannosylation of Glycans in Pichia pastoris and Candida albicans
Mille, C., Bobrowicz, P., Trinel, P. A., Li, H., Maes, E., Guérardel, Y., Fradin, C., Martinez‐Esparza, M., Davidson, R. C., Janbon, G., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708825200 · Cited by 94 · see citing works
Flocculation protein structure and cell–cell adhesion mechanism in Saccharomyces cerevisiae
Goossens, K. V. Y., & Willaert, R. (2010) · Biotechnology Letters · doi:10.1007/s10529-010-0352-3 · Cited by 92 · see citing works
The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast
Peyroche, A., Courbeyrette, R., Rambourg, A., & Jackson, C. L. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.12.2241 · Cited by 77 · see citing works
Free oligosaccharide regulation during mammalian protein N-glycosylation
Chantret, I., & Moore, S. E. H. (2007) · Glycobiology · doi:10.1093/glycob/cwn003 · Cited by 75 · see citing works
Glycoengineered antibodies: towards the next-generation of immunotherapeutics
Mastrangeli, R., Palinsky, W., & Bierau, H. (2018) · Glycobiology · doi:10.1093/glycob/cwy092 · Cited by 74 · see citing works
Evaluation of different yeast cell wall mutants and microalgae strains as feed for gnotobiotically grown brine shrimp Artemia franciscana
Marques, A., Dhont, J., Sorgeloos, P., & Bossier, P. (2004) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2004.06.008 · Cited by 74 · see citing works
Functional Characterization of the Hansenula polymorpha HOC1, OCH1, and OCR1 Genes as Members of the Yeast OCH1 Mannosyltransferase Family Involved in Protein Glycosylation
Kim, M. W., Kim, E. J., Kim, J., Park, J., Oh, D., Shimma, Y., Chiba, Y., Jigami, Y., Rhee, S. K., & Kang, H. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508507200 · Cited by 71 · see citing works
The Components of the Saccharomyces cerevisiaeMannosyltransferase Complex M-Pol I Have Distinct Functions in Mannan Synthesis
Stolz, J., & Munro, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208023200 · Cited by 71 · see citing works
An episomal expression vector for screening mutant gene libraries in Pichia pastoris
Lee, C. C., Williams, T., Wong, D. W. S., & Robertson, G. H. (2005) · Plasmid · doi:10.1016/j.plasmid.2004.12.001 · Cited by 69 · see citing works
α-1,6-Mannosylation of N-Linked Oligosaccharide Present on Cell Wall Proteins Is Required for Their Incorporation into the Cell Wall in the Filamentous Fungus Neurospora crassa
Maddi, A., & Free, S. J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00134-10 · Cited by 67 · see citing works
An Engineered Saccharomyces cerevisiae Strain Binds the Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody 2G12 and Elicits Mannose-Specific gp120-Binding Antibodies
Luallen, R. J., Lin, J., Fu, H., Cai, K. K., Agrawal-Gamse, C., Mboudjeka, I., Lee, F.-H., Montefiori, D. C., Smith, D. F., Doms, R. W., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00412-08 · Cited by 65 · see citing works
Molecular and Phenotypic Analysis ofCaVRG4, Encoding an Essential Golgi Apparatus GDP-Mannose Transporter
Nishikawa, A., Poster, J. B., Jigami, Y., & Dean, N. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.1.29-42.2002 · Cited by 65 · see citing works
Self-citation
An α-1,3-Mannosyltransferase of Cryptococcus neoformans
Sommer, U., Liu, H., & Doering, T. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307223200 · Cited by 63 · see citing works
Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-mannose
Engel, J., Schmalhorst, P. S., & Routier, F. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.398321 · Cited by 63 · see citing works
Differential virulence of Candida glabrata glycosylation mutants
West, L., Lowman, D. W., Mora-Montes, H. M., Grubb, S., Murdoch, C., Thornhill, M. H., Gow, N. A. R., Williams, D., & Haynes, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.478743 · Cited by 62 · see citing works
Glycosyltransferases and their products: cryptococcal variations on fungal themes
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N-Glycan Modification in Aspergillus Species
Kainz, E., Gallmetzer, A., Hatzl, C., Nett, J. H., Li, H., Schinko, T., Pachlinger, R., Berger, H., Reyes-Domínguez, Y., Bernreiter, A., et al. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01058-07 · Cited by 58 · see citing works
Functional analysis of the ALG3 gene encoding the Dol-P-Man: Man5GlcNAc2-PP-Dol mannosyltransferase enzyme of P. pastoris
Davidson, R. C. (2004) · Glycobiology · doi:10.1093/glycob/cwh023 · Cited by 58 · see citing works
Morphodynamics of the Secretory Pathway
Képès, F., Rambourg, A., & Satiat‐Jeunemaître, B. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)42002-6 · Cited by 57 · see citing works
Retrograde Transport of the Mannosyltransferase Och1p to the Early Golgi Requires a Component of the COG Transport Complex
Bruinsma, P., Spelbrink, R. G., & Nothwehr, S. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405500200 · Cited by 55 · see citing works
Characterization of a novel enzyme—Starmerella bombicola lactone esterase (SBLE)—responsible for sophorolipid lactonization
Ciesielska, K., Roelants, S. L. K. W., Bogaert, I. V., Waele, S. D., Vandenberghe, I. H. M., Groeneboer, S., Soetaert, W., & Devreese, B. V. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7633-2 · Cited by 55 · see citing works
Characterization of N-linked oligosaccharides assembled on secretory recombinant glucose oxidase and cell wall mannoproteins from the methylotrophic yeast Hansenula polymorpha
Kim, M. W. (2003) · Glycobiology · doi:10.1093/glycob/cwh030 · Cited by 54 · see citing works
Heterologous Protein Expression and Secretion in Yarrowia lipolytica
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MNN5 Encodes an Iron-Regulated α-1,2-Mannosyltransferase Important for Protein Glycosylation, Cell Wall Integrity, Morphogenesis, and Virulence in Candida albicans
Bai, C., Xu, X.-L., Chan, F.-Y., Lee, R. T. H., & Wang, Y. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.2.238-247.2006 · Cited by 52 · see citing works
Engineering Yeast for Producing Human Glycoproteins: Where are We Now?
Laukens, B., Visscher, C. D., & Callewaert, N. (2015) · Future Microbiology · doi:10.2217/fmb.14.104 · Cited by 51 · see citing works
The Pathogenic Fungus Cryptococcus neoformans Expresses Two Functional GDP-Mannose Transporters with Distinct Expression Patterns and Roles in Capsule Synthesis
Cottrell, T. R., Griffith, C. L., Liu, H., Nenninger, A. A., & Doering, T. L. (2007) · Eukaryotic Cell · doi:10.1128/ec.00015-07 · Cited by 51 · see citing works
Immunoisolaton of the Yeast Golgi Subcompartments and Characterization of a Novel Membrane Protein, Svp26, Discovered in the Sed5-Containing Compartments
Inadome, H., Noda, Y., Adachi, H., & Yoda, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7696-7710.2005 · Cited by 51 · see citing works
Unraveling Unique Structure and Biosynthesis Pathway of N-Linked Glycans in Human Fungal Pathogen Cryptococcus neoformans by Glycomics Analysis
Park, J. N., Lee, D. J., Kwon, O., Oh, D., Bahn, Y., & Kang, H. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.354209 · Cited by 50 · see citing works
The N-Terminal Domain of the Flo1 Flocculation Protein from Saccharomyces cerevisiae Binds Specifically to Mannose Carbohydrates
Goossens, K. V. Y., Stassen, C., Stals, I., Donohue, D. S., Devreese, B. V., Greve, H. D., & Willaert, R. (2010) · Eukaryotic Cell · doi:10.1128/ec.00185-10 · Cited by 50 · see citing works
Galactofuranoic‐oligomannose N‐linked glycans of α‐galactosidase A fromAspergillus niger
Wallis, G. L. F., Easton, R. L., Jolly, K., HEMMING, F. W., & Peberdy, J. F. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02322.x · Cited by 50 · see citing works
A Molecular and Genomic View of the Fungal Cell Wall
Klis, F. M., Ram, A. F. J., & de Groot, P. W. J. (2007) · Springer eBooks · doi:10.1007/978-3-540-70618-2_4 · Cited by 48 · see citing works
Molecular characterization of Vig4/Vrg4 GDP‐mannose transporter of the yeast Saccharomyces cerevisiae
Abe, M., Hashimoto, H., & Yoda, K. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01177-1 · Cited by 47 · see citing works
Glycosylation status of theC. albicanscell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling
Sheth, C. C., Hall, R. A., Lewis, L. E., Brown, A. J. P., Odds, F. C., Erwig, L. P., & Gow, N. A. R. (2011) · Medical Mycology · doi:10.3109/13693786.2010.551425 · Cited by 45 · see citing works
Disruption of the OCH1 and MNN1 genes decrease N-glycosylation on glycoprotein expressed in Kluyveromyces lactis
Liu, B., Gong, X., Chang, S., Yang, Y., Song, M., Duan, D., Wang, L., Ma, Q., & Wu, J. (2009) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2009.06.016 · Cited by 43 · see citing works
Engineering of Yeast Glycoprotein Expression
Wachter, C. D., Landuyt, L. V., & Callewaert, N. (2018) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2018_69 · Cited by 43 · see citing works
Breaking the barrier to fast electron transfer
Demin, S., & Hall, E. A. H. (2009) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2009.03.006 · Cited by 43 · see citing works
Surface Hydrophobicity Changes of Two Candida albicans Serotype B mnn4 Δ Mutants
Singleton, D. R., Masuoka, J., & Hazen, K. C. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.4.639-648.2005 · Cited by 43 · see citing works
Engineering of the Yeast Yarrowia lipolytica for the Production of Glycoproteins Lacking the Outer-Chain Mannose Residues of N-Glycans
Song, Y., Choi, M. H., Park, J., Kim, M. W., Kim, E. J., Kang, H. A., & Kim, J. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02058-06 · Cited by 43 · see citing works
A combinatorial genetic library approach to target heterologous glycosylation enzymes to the endoplasmic reticulum or the Golgi apparatus of Pichia pastoris
Nett, J. H., Stadheim, T. A., Li, H., Bobrowicz, P., Hamilton, S. R., Davidson, R. C., Choi, B., Mitchell, T., Bobrowicz, B., Rittenhour, A. M., et al. (2010) · Yeast · doi:10.1002/yea.1835 · Cited by 41 · see citing works
Considerations of critical quality attributes in the analytical comparability assessment of biosimilar products
Kwon, O.-S., Joung, J., Park, Y., Kim, C., & Hong, S. H. (2017) · Biologicals · doi:10.1016/j.biologicals.2017.04.005 · Cited by 40 · see citing works
Regulation of the Transport and Protein Levels of the Inositol Phosphorylceramide Mannosyltransferases Csg1 and Csh1 by the Ca2+-binding Protein Csg2
Uemura, S., Kihara, A., Iwaki, S., Inokuchi, J., & Igarashi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606649200 · Cited by 40 · see citing works
Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants
Avaro, S., Belgareh‐Touzé, N., Sibella-Arguelles, C., Volland, C., & Haguenauer‐Tsapis, R. (2002) · Yeast · doi:10.1002/yea.838 · Cited by 40 · see citing works
A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts
McDonald, A. G., Tipton, K. F., & Davey, G. P. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004844 · Cited by 39 · see citing works
Protein N‐glycosylation determines functionality of the Saccharomyces cerevisiae cell wall integrity sensor Mid2p
Hutzler, F., Gerstl, R., Lommel, M., & Strahl, S. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06243.x · Cited by 39 · see citing works
Expression of Trichoderma reesei cellulases CBHI and EGI in Ashbya gossypii
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Authors: Dean, N.
Affiliations: Stony Brook University (US)
Corresponding author: Dean, Neta
ORCID: Dean, Neta
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 1999-01
Volume: 1426
Issue: 2
Pages: 309-322
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/s0304-4165(98)00132-9
OpenAlex: W2119861230
Cited by: 188
References: 96
Citations by year: 2025: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 4 · 2013: 10 · 2012: 7
FWCI: 0.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: asparagine-linked glycosylation, N-glycans, Golgi apparatus, Saccharomyces cerevisiae, mannosyltransferase, protein glycosylation, glycoconjugate synthesis, enzyme regulation
MeSH terms: Asparagine, Carbohydrate Sequence, Glycoproteins, Glycosylation, Golgi Apparatus, Intracellular Membranes, Mannosyltransferases, Molecular Sequence Data, Nitrogen, Oligosaccharides, Saccharomyces cerevisiae

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Asparagine-linked glycosylation in the yeast Golgi

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