Differential virulence of Candida glabrata glycosylation mutants
Open accessAbstract
The fungus Candida glabrata is an important and increasingly common pathogen of humans, particularly in immunocompromised hosts. Despite this, little is known about the attributes that allow this organism to cause disease or its interaction with the host immune system. However, in common with other fungi, the cell wall of C. glabrata is the initial point of contact between the host and pathogen, and as such, it is likely to play an important role in mediating interactions and hence virulence. Here, we show both through genetic complementation and polysaccharide structural analyses that C. glabrata ANP1, MNN2, and MNN11 encode functional orthologues of the respective Saccharomyces cerevisiae mannosyltransferases. Furthermore, we show that deletion of the C. glabrata Anp1, Mnn2, and Mnn11 mannosyltransferases directly affects the structure of the fungal N -linked mannan, in line with their predicted functions, and this has implications for cell wall integrity and consequently virulence. C. glabrata anp1 and mnn2 mutants showed increased virulence, compared with wild-type (and mnn11 ) cells. This is in contrast to Candida albicans where inactivation of genes involved in mannan biosynthesis has usually been linked to an attenuation of virulence. In the long term, a better understanding of the attributes that allow C. glabrata to cause disease will provide insights that can be adopted for the development of novel therapeutic and diagnostic approaches. Background: Candida glabrata virulence is poorly understood at the molecular level. Results: Inactivation of components of the C. glabrata glycosylation machinery results in changes in fungal mannan structure and altered virulence. Conclusion: Changes in C. glabrata cell wall architecture impact the host-pathogen interactions. Significance: Greater understanding of C. glabrata virulence will provide insights that can be adopted for development of novel diagnostic and therapeutic interventions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mutants lacking CgAnp1 and CgMnn2 were hyperadherent to human microvascular endothelial cells HMEC-1.
“In addition, two enzymes of the N-linked glycosylation system, α-1,6-mannosyltransferase (CgAnp1) and α-1,2-mannosyltransferase (CgMnn2), have also been implicated in adherence, as mutants lacking these enzymes were hyperadherent to the human microvascular endothelial cells HMEC-1 [138].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [138]
CgAnp1 and CgMnn2 are implicated in adherence.
“In addition, two enzymes of the N-linked glycosylation system, α-1,6-mannosyltransferase (CgAnp1) and α-1,2-mannosyltransferase (CgMnn2), have also been implicated in adherence, as mutants lacking these enzymes were hyperadherent to the human microvascular endothelial cells HMEC-1 [138].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rudin, W. (1973) · Cited by 13,708 · see citing works
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E. M., Li, J., Hieter, P., & Boeke, J. D. (1998) · Yeast · doi:10.1002/(sici)1097-0061(19980130)14:2 · Cited by 3,411 · see citing works
Gietz, R. D., & Sugino, A. (1988) · Gene · doi:10.1016/0378-1119(88)90185-0 · Cited by 2,901 · see citing works
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742 · see citing works
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793 · see citing works
Dujon, B., Sherman, D., Fischer, G., Durrens, P., Casaregola, S., Lafontaine, I., de Montigny, J., Marck, C., Neuvéglise, C., Talla, E., et al. (2004) · Nature · doi:10.1038/nature02579 · Cited by 1,623 · see citing works
The structure and synthesis of the fungal cell wall
Bowman, S. M., & Free, S. J. (2006) · BioEssays · doi:10.1002/bies.20441 · Cited by 1,320 · see citing works
Dectin-1 is required for β-glucan recognition and control of fungal infection
Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C. H., Botto, M., Gordon, S., et al. (2006) · Nature Immunology · doi:10.1038/ni1408 · Cited by 1,155 · see citing works
Self-citationThe cell wall: a carbohydrate armour for the fungal cell
Latgé, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05872.x · Cited by 987 · see citing works
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946 · see citing works
Self-citationCell wall construction in Saccharomyces cerevisiae
Klis, F. M., Boorsma, A., & de Groot, P. W. J. (2006) · Yeast · doi:10.1002/yea.1349 · Cited by 776 · see citing works
Romani, L. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1255 · Cited by 759 · see citing works
The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
Reuß, O., Vik, Å., Kolter, R., & Morschhäuser, J. (2004) · Gene · doi:10.1016/j.gene.2004.06.021 · Cited by 744 · see citing works
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.
Staab, J., Bradway, S. D., Fidel, P., & Sundstrom, P. (1999) · Science · doi:10.1126/science.283.5407.1535 · Cited by 683 · see citing works
Overview of N- and O-linked oligosaccharide structures found in various yeast species
Gemmill, T. R., & Trimble, R. B. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00126-3 · Cited by 439 · see citing works
Cormack, B. P., Ghori, N., & Falkow, S. (1999) · Science · doi:10.1126/science.285.5427.578 · Cited by 383 · see citing works
Molecular organization of the cell wall of <i>Candida albicans</i> and its relation to pathogenicity
Ruiz-Herrera, J., Victoria Elorza, M., ValentÃn, E., & Sentandreu, R. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2005.00017.x · Cited by 376 · see citing works
Extrathymic T-cell differentiation in vitro
Pawelec, G. (2004) · Nature reviews. Immunology · doi:10.1038/nri1257-c1 · Cited by 362 · see citing works
Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1.
Gale, C. A., Bendel, C. M., McClellan, M., Hauser, M., Becker, J. M., Berman, J., & Hostetter, M. K. (1998) · Science · doi:10.1126/science.279.5355.1355 · Cited by 356 · see citing works
Wisplinghoff, H., Seifert, H., Tallent, S. M., Bischoff, T., Wenzel, R. P., & Edmond, M. B. (2003) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000078159.53132.40 · Cited by 350 · see citing works
Importance of the Candida albicans cell wall during commensalism and infection
Gow, N. A., & Hube, B. (2012) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.04.005 · Cited by 347 · see citing works
Self-citationEncapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans
Kwon-Chung, K. J., & Rhodes, J. C. (1986) · Infection and Immunity · doi:10.1128/iai.51.1.218-223.1986 · Cited by 345 · see citing works
Method for Fingerprinting Yeast Cell Wall Mannans
Kocourek, J., & Ballou, C. E. (1969) · Journal of Bacteriology · doi:10.1128/jb.100.3.1175-1181.1969 · Cited by 331 · see citing works
Immune Recognition of <i>Candida albicans</i> β‐glucan by Dectin‐1
Gow, N. A. R., Netea, M. G., Munro, C. A., Ferwerda, G., Bates, S., Mora‐Montes, H. M., Walker, L., Jansen, T., Jacobs, L., Tsoni, V., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/523110 · Cited by 314 · see citing works
Self-citationAdams, E. L., Rice, P. J., Graves, B. M., Ensley, H. E., Yu, H., Brown, G. D., Gordon, S., Monteiro, M. A., Papp-Szabó, E., Lowman, D. W., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.133124 · Cited by 312 · see citing works
Self-citationMueller, A., Raptis, J., Rice, P. J., Kalbfleisch, J. H., Stout, R. D., Ensley, H. E., Browder, W., & Williams, D. L. (2000) · Glycobiology · doi:10.1093/glycob/10.4.339 · Cited by 300 · see citing works
Self-citationBallou, C. E. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)85038-p · Cited by 298 · see citing works
Pattern recognition: recent insights from Dectin-1
Reid, D. M., Gow, N. A. R., & Brown, G. D. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.003 · Cited by 291 · see citing works
Self-citationKaur, R., Ma, B., & Cormack, B. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611195104 · Cited by 284 · see citing works
Nakayama, K.-I., Nagasu, T., Shimma, Y., Kuromitsu, J., & Jigami, Y. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05316.x · Cited by 260 · see citing works
Zhao, X., Oh, S.-H., Cheng, G., Green, C. B., Nuessen, J. A., Yeater, K., Leng, R. P., Brown, A. J. P., & Hoyer, L. L. (2004) · Microbiology · doi:10.1099/mic.0.26943-0 · Cited by 254 · see citing works
Nicotinic Acid Limitation Regulates Silencing of <i>Candida</i> Adhesins During UTI
Domergue, R., Castaño, I., De Las Peñas, A., Zupancic, M., Lockatell, V., Hebel, J. R., Johnson, D., & Cormack, B. P. (2005) · Science · doi:10.1126/science.1108640 · Cited by 249 · see citing works
Outer Chain N-Glycans Are Required for Cell Wall Integrity and Virulence of Candida albicans
Bates, S., Hughes, H. B., Munro, C. A., Thomas, W. P. H., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Brown, A. J. P., Odds, F. C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510360200 · Cited by 238 · see citing works
Self-citationMrša, V., Seidl, T. L., Gentzsch, M., & Tanner, W. (1997) · Yeast · doi:10.1002/(sici)1097-0061(19970930)13:12 · Cited by 226 · see citing works
Jungmann, J., & Munro, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.423 · Cited by 224 · see citing works
Munro, C. A., Bates, S., Buurman, E. T., Hughes, H. B., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Bain, J. M., Brand, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411413200 · Cited by 200 · see citing works
Self-citationCastaño, I., Pan, S., Zupancic, M., Hennequin, C., Dujon, B., & Cormack, B. P. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04465.x · Cited by 188 · see citing works
Asparagine-linked glycosylation in the yeast Golgi
Dean, N. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00132-9 · Cited by 188 · see citing works
Mannosylphosphate transfer to yeast mannan
Jigami, Y., & Odani, T. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00134-2 · Cited by 185 · see citing works
Shibata, N., Suzuki, A., Kobayashi, H., & Okawa, Y. (2007) · Biochemical Journal · doi:10.1042/bj20070081 · Cited by 178 · see citing works
Host–microbe interactions: innate pattern recognition of fungal pathogens
van de Veerdonk, F. L., Kullberg, B. J., van der Meer, J. W., Gow, N. A., & Netea, M. G. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.06.002 · Cited by 169 · see citing works
Self-citationMultiple Functions of Pmt1p-mediated ProteinO-Mannosylation in the Fungal Pathogen Candida albicans
Timpel, C., Strahl-Bolsinger, S., Ziegelbauer, K., & Ernst, J. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20837 · Cited by 161 · see citing works
The molecular basis for the immunogenicity ofCryptococcus neoformansmannoproteins
Levitz, S. M., & Specht, C. A. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00071.x · Cited by 154 · see citing works
The KTR and MNN1 mannosyltransferase families of Saccharomyces cerevisiae
Lussier, M. P., Sdicu, A., & Bussey, H. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00133-0 · Cited by 141 · see citing works
Processing glycosidases of Saccharomyces cerevisiae
Herscovics, A. A. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00129-9 · Cited by 137 · see citing works
Yip, C., Welch, S. K., Klebl, F., Gilbert, T. L., Seidel, P., Grant, F. J., O’Hara, P. J., & MacKay, V. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2723 · Cited by 137 · see citing works
Jungmann, J., Rayner, J. C., & Munro, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6579 · Cited by 136 · see citing works
Innate immune mechanisms for recognition and uptake of Candida species
Netea, M. G., & Maródi, L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.007 · Cited by 134 · see citing works
Loss of Cell Wall Mannosylphosphate in Candida albicans Does Not Influence Macrophage Recognition
Hobson, R. P., Munro, C. A., Bates, S., MacCallum, D. M., Cutler, J. E., Heinsbroek, S. E. M., Brown, G. D., Odds, F. C., & Gow, N. A. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405003200 · Cited by 131 · see citing works
Self-citationRayner, J. C., & Munro, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26836 · Cited by 129 · see citing works
Mora-Montes, H. M., Bates, S., Netea, M. G., Castillo, L., Brand, A., Buurman, E. T., Díaz-Jiménez, D. F., Jan Kullberg, B., Brown, A. J. P., Odds, F. C., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081513 · Cited by 129 · see citing works
Self-citationSaccharomyces cerevisiae mutants that make mannoproteins with a truncated carbohydrate outer chain.
Ballou, L., Cohen, R. E., & Ballou, C. E. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70728-5 · Cited by 117 · see citing works
Hill, K., Boone, C. M., Goebl, M. G., Puccia, R., Sdicu, A., & Bussey, H. (1992) · Genetics · doi:10.1093/genetics/130.2.273 · Cited by 101 · see citing works
Timpel, C., Zink, S., Strahl‐Bolsinger, S., Schröppel, K., & Ernst, J. F. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.11.3063-3071.2000 · Cited by 101 · see citing works
Lussier, M., Sdicu, A., Bussereau, F., Jacquet, M., & Bussey, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15527 · Cited by 99 · see citing works
Chapman, R. E., & Munro, S. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06817.x · Cited by 91 · see citing works
Protein Glycosylation in Candida
Mora-Montes, H. M., Ponce‐Noyola, P., Villagómez-Castro, J. C., Gow, N. A. R., Flores-Carreón, A., & López-Romero, E. (2009) · Future Microbiology · doi:10.2217/fmb.09.88 · Cited by 90 · see citing works
Self-citationOlson, G. M., Fox, D. S., Wang, P., Alspaugh, J. A., & Buchanan, K. L. (2006) · Eukaryotic Cell · doi:10.1128/ec.00182-06 · Cited by 80 · see citing works
Kamran, M., Calcagno, A.-M., Findon, H., Bignell, E., Jones, M. D., Warn, P., Hopkins, P., Denning, D. W., Butler, G., Rogers, T., et al. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.546-552.2004 · Cited by 75 · see citing works
Self-citationIsolation of a Candida glabrata centromere and its use in construction of plasmid vectors
Kitada, K., Yamaguchi, E., & Arisawa, M. (1996) · Gene · doi:10.1016/0378-1119(96)00132-1 · Cited by 70 · see citing works
Calcagno-Pizarelli, A. M., Bignell, E., Warn, P. A., Jones, M. D., Denning, D. W., Mühlschlegel, F. A., Rogers, T. R., & Haynes, K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03755.x · Cited by 70 · see citing works
Self-citationHäusler, A., & Robbins, P. W. (1992) · Glycobiology · doi:10.1093/glycob/2.1.77 · Cited by 68 · see citing works
The N‐oligosaccharyltransferase complex from yeast
Knauer, R., & Lehle, L. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00356-4 · Cited by 67 · see citing works
Adhesion of Candida albicans to Endothelial Cells under Physiological Conditions of Flow
Grubb, S. E. W., Murdoch, C., Sudbery, P. E., Saville, S. P., Lopez-Ribot, J. L., & Thornhill, M. H. (2009) · Infection and Immunity · doi:10.1128/iai.00518-09 · Cited by 66 · see citing works
Self-citationLachance, M., & PANG, W.-M. (1997) · Yeast · doi:10.1002/(sici)1097-0061(19970315)13:3 · Cited by 64 · see citing works
Lussier, M., Sdicu, A., Camirand, A., & Bussey, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.11001 · Cited by 62 · see citing works
Candida glabrata fungaemia in intensive care units
Ruan, S., Lee, L., Jerng, J., Yu, C., & Hsueh, P. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01892.x · Cited by 55 · see citing works
Shibata, N., Kobayashi, H., Okawa, Y., & Suzuki, S. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03622.x · Cited by 53 · see citing works
Murciano, C., Moyes, D. L., Runglall, M., Islam, A., Mille, C., Fradin, C., Poulain, D., Gow, N. A. R., & Naglik, J. R. (2011) · Infection and Immunity · doi:10.1128/iai.05591-11 · Cited by 52 · see citing works
Self-citationJawhara, S., Mogensen, E. G., Maggiotto, F., Fradin, C., Sarazin, A., Dubuquoy, L., Maes, E., Guérardel, Y., Janbon, G., & Poulain, D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.329300 · Cited by 51 · see citing works
1H- and 13C-n.m.r.-spectral study of synthetic methyl d-manno-oligosaccharides
Ogawa, T., & Sasajima, K. (1981) · Carbohydrate Research · doi:10.1016/s0008-6215(00)80667-9 · Cited by 50 · see citing works
Characterization of the PMT Gene Family in Cryptococcus neoformans
Willger, S. D., Ernst, J. F., Alspaugh, J. A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006321 · Cited by 50 · see citing works
ROMERO, P. A., LUSSIER, M., Sdicu, A., Bussey, H., & Herscovics, A. A. (1997) · Biochemical Journal · doi:10.1042/bj3210289 · Cited by 49 · see citing works
Kobayashi, H., Mitobe, H., Takahashi, K., Yamamoto, T., Shibata, N., & Suzuki, S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90739-j · Cited by 46 · see citing works
Weig, M., Haynes, K., Rogers, T. R., Kurzai, O., Frosch, M., & Mühlschlegel, F. A. (2001) · Microbiology · doi:10.1099/00221287-147-8-2007 · Cited by 46 · see citing works
Self-citationMacCallum, D. M., Findon, H., Kenny, C. C., Butler, G., Haynes, K., & Odds, F. C. (2006) · Infection and Immunity · doi:10.1128/iai.00817-06 · Cited by 45 · see citing works
Self-citationGlee, P. M., Cutler, J. E., Benson, E. E., Bargatze, R. F., & Hazen, K. C. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.2815-2820.2001 · Cited by 42 · see citing works
Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome
Stead, D., Walker, J., Holcombe, L. J., Gibbs, S. R. S., Yin, Z., Selway, L., Butler, G., Brown, A. J. P., & Haynes, K. (2009) · PROTEOMICS · doi:10.1002/pmic.200800706 · Cited by 29 · see citing works
Self-citationCalcagno-Pizarelli, A. M., Bignell, E., Rogers, T. R., Canedo, M., Mühlschlegel, F. A., & Haynes, K. (2004) · Yeast · doi:10.1002/yea.1125 · Cited by 29 · see citing works
Self-citationTakahashi, S., Kudoh, A., Okawa, Y., & Shibata, N. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08564.x · Cited by 25 · see citing works
Calcagno-Pizarelli, A. M., Bignell, E., Rogers, T. R., Jones, M. D., Mühlschlegel, F. A., & Haynes, K. (2005) · Medical Mycology · doi:10.1080/13693780400006088 · Cited by 25 · see citing works
Self-citationStead, D., Findon, H., Yin, Z., Walker, J., Selway, L., Cash, P., Dujon, B., Hennequin, C., Brown, A. J. P., & Haynes, K. (2005) · PROTEOMICS · doi:10.1002/pmic.200401064 · Cited by 22 · see citing works
Self-citationLižičárová, I., Matulová, M., Capek, P., & Machová, E. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.03.007 · Cited by 19 · see citing works
Kobayashi, H., Oyamada, H., Matsuda, K., et al. (2003) · Archives of Microbiology · doi:10.1007/s00203-003-0550-7 · Cited by 18 · see citing works
Kobayashi, H., Oyamada, H., Iwadate, N., et al. (1998) · Archives of Microbiology · doi:10.1007/s002030050559 · Cited by 16 · see citing works
Okawa, Y., & Goto, K. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.187 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [72]Findon H. (2006) Microbiology. Ph.D. thesis, Imperial College London, London
Cited by
Sorted by citations
Fungal Strategies to Evade the Host Immune Recognition
Hernández-Chávez, M., Pérez-García, L., Niño-Vega, G., & Mora-Montes, H. (2017) · Journal of Fungi · doi:10.3390/jof3040051 · Cited by 173 · see citing works
Self-citationCandida glabrata: A Lot More Than Meets the Eye
Kumar, K., Askari, F., Sahu, M. S., & Kaur, R. (2019) · Microorganisms · doi:10.3390/microorganisms7020039 · Cited by 128 · see citing works
Innate immune responses against the fungal pathogen Candida auris
Wang, Y., Zou, Y., Chen, X., Li, H., Yin, Z., Zhang, B., Xu, Y., Zhang, Y., Zhang, R., Huang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31201-x · Cited by 107 · see citing works
Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin
Galocha, M., Pais, P., Cavalheiro, M., Pereira, D., Viana, R., & Teixeira, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092345 · Cited by 105 · see citing works
Kasper, L., Seider, K., Gerwien, F., Allert, S., Brunke, S., Schwarzmüller, T., Ames, L., Zubiria-Barrera, C., Mansour, M. K., Becken, U., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096015 · Cited by 59 · see citing works
Self-citationDeletion of <i>ADA2</i> Increases Antifungal Drug Susceptibility and Virulence in Candida glabrata
Yu, S.-J., Chang, Y.-L., & Chen, Y.-L. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01924-17 · Cited by 43 · see citing works
<i>Candida glabrata</i> : new tools and technologies—expanding the toolkit
Ho, H.-L., & Haynes, K. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov066 · Cited by 29 · see citing works
Self-citationShe, X., Calderone, R., Kruppa, M., Lowman, D., Williams, D., Zhang, L., Gao, Y., Khamooshi, K., Liu, W., & Li, D. (2016) · PLOS ONE · doi:10.1371/journal.pone.0147175 · Cited by 27 · see citing works
Self-citationHistone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata
Yu, S., Paderu, P., Lee, A., Eirekat, S., Healey, K., Chen, L., Perlin, D. S., & Zhao, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00963-22 · Cited by 23 · see citing works
<i>Candida glabrata's</i> recurrent infections: biofilm formation during Amphotericin B treatment
Rodrigues, C. F., Silva, S., Azeredo, J., & Henriques, M. (2016) · Letters in Applied Microbiology · doi:10.1111/lam.12600 · Cited by 21 · see citing works
- Authors
- West, L., Lowman, D. W., Mora-Montes, H. M., Grubb, S., Murdoch, C., Thornhill, M. H., Gow, N. A. R., Williams, D., & Haynes, K.
- Affiliations
- Imperial College London (GB)
- East Tennessee State University (US)
- University of Sheffield (GB)
- University of Aberdeen (GB)
- University of Exeter (GB)
- Corresponding author
- Haynes, Ken
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 288
- Issue
- 30
- Pages
- 22006-22018
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3724654
- OpenAlex
- W2059639333
- Cited by
- 62
- References
- 88
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Research Exeter (University of Exeter) (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- Figshare (submittedVersion)
- Funders
- Wellcome Trust (072420, 080088, 075174)
- National Institutes of Health
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BBS/B/10331, BB/F005210/2, BB/F005210/1, BBF005210)
- National Institute of General Medical Sciences (R01GM053522, R01GM53522)
- National Institute of Allergy and Infectious Diseases (R21AI065549)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- Candida glabrata, virulence, glycosylation, mannosyltransferase, cell wall integrity, fungal cell wall, host-pathogen interaction, gene complementation, polysaccharide structure, immunocompromised patients
- MeSH terms
- Animals, Candidiasis, Carbohydrate Sequence, Cell Line, Cell Wall, Fungal Proteins, Genetic Complementation Test, Glycosylation, Humans, Isoenzymes, Male, Mannans, Mannosyltransferases, Molecular Sequence Data, Mutation, Magnetic Resonance Spectroscopy, Virulence, Saccharomyces cerevisiae Proteins, Candida glabrata, Endothelial Cells, Mice, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
