p21WAF1/Cip1: more than a break to the cell cycle?

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

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New functional activities for the p21 family of CDK inhibitors.

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

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Cyclin-Binding Motifs Are Essential for the Function of p21 CIP1

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Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen

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Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21

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5-Fluorouracil: mechanisms of action and clinical strategies

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p21 in cancer: Intricate networks and multiple activities

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PCNA, the Maestro of the Replication Fork

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Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

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The Dual Roles of NRF2 in Cancer

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Untitled work

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When NRF2 Talks, Who's Listening?

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Hallmarks of senescence in carcinogenesis and cancer therapy

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Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts

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A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

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Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence

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Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

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Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

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p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

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The lauric acid-activated signaling prompts apoptosis in cancer cells

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Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

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Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin

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Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells

Helt, A.-M., Funk, J. O., & Galloway, D. A. (2002) · Journal of Virology · doi:10.1128/jvi.76.20.10559-10568.2002 · Cited by 90

Genome-Wide MRNA Expression Profiling in Vastus Lateralis of COPD Patients with Low and Normal Fat Free Mass Index and Healthy Controls

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Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis

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Senescence determines the fate of activated rat pancreatic stellate cells

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IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells

Zuo, S., Liu, C., Wang, J., Wang, F., Xu, W., Cui, S., Yuan, L., Chen, X., Fan, W., Cui, M., et al. (2012) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-012-1153-y · Cited by 58

Reduction of both number and proliferative activity of human endothelial progenitor cells in obesity

Tobler, K., Freudenthaler, A., Baumgartner-Parzer, S. M., Wolzt, M., Ludvik, B., Nansalmaa, E., Nowotny, P. J., Seidinger, D., Steiner, S., Luger, A., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.280 · Cited by 59

The Activity and Stability of the Intrinsically Disordered Cip/Kip Protein Family AreRegulated by Non-Receptor TyrosineKinases

Huang, Y., Yoon, M.-K., Otieno, S., Lelli, M., & Kriwacki, R. W. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.11.011 · Cited by 36

p21 WAF1 /Cip1 limits senescence and acinar‐to‐ductal metaplasia formation during pancreatitis

Grabliauskaite, K., Hehl, A. B., Seleznik, G. M., Saponara, E., Schlesinger, K., Zuellig, R. A., Dittmann, A., Bain, M., Reding, T., Sonda, S., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4440 · Cited by 27

Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s disease patients

Esteras, N., Alquézar, C., Bermejo-Pareja, F., Bialopiotrowicz, E., Wojda, U., & Martín-Requero, Á. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.10.014 · Cited by 25

ATR controls the p21WAF1/Cip1 protein up‐regulation and apoptosis in response to low UV fluences

Al‐Khalaf, H. H., Hendrayani, S., & Aboussekhra, A. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.20864 · Cited by 13

Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity

Colón-Mesa, I., Fernández-Galilea, M., Sáinz, N., Lopez-Yus, M., Artigas, J. M., Arbonés-Mainar, J. M., Félix-Soriano, E., Escoté, X., & Moreno-Aliaga, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111745 · Cited by 9