The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention
Abstract
The present study used microdialysis techniques to compare acetylcholine release in the frontoparietal cortex of rats performing in a task requiring sustained attention with that of rats performing in two control procedures. The two control procedures were a fixed-interval 9-s schedule of reinforcement assessing primarily the effects of operant responding and comparable reward rates, and an operant procedure designed to test the effects of lever extension to prompt responding. These two control procedures involved comparable sensory-motor and motivational variables to those of the sustained attention task, but did not explicitly tax attentional processes. Performance of the sustained attention task was associated with a significant increase in cortical acetylcholine efflux, reaching a maximum of nearly 140%. Performance of the two control procedures was associated with significantly smaller (approximately 50%) increases in cortical acetylcholine release. This robust dissociation between attentional and control performance-associated increases in cortical acetylcholine release resulted, in part, from the elimination of the pre-task transfer of the animals into the operant chambers and the associated increases in acetylcholine release observed in previous studies. The present results support the hypothesis that demands on attentional performance, as opposed to the frequency of lever pressing, reward delivery and other task-related variables, selectively activate the basal forebrain corticopetal cholinergic system.
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“These increases in ACh release were not observed in animals performing behavioral procedures that controlled for non-cognitive performance variables, such as lever pressing and reward rates, or the presentation of stimuli and distractors in contexts that do not require attention (e.g., Himmelheber et al, 1997; Arnold et al, 2002).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Arnold et al, 2002
In the citing paper
“Measures of ACh release in task-performing animals, using microdialysis, consistently demonstrated attentional performance-associated increases in cortical ACh release.”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Arnold et al, 2002
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Zar, J. H. (1996) · Cited by 7,837
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348
The cognitive neuroscience of sustained attention: where top-down meets bottom-up.
Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194
Self-citationCognitive functions of cortical acetylcholine: toward a unifying hypothesis
Sarter, M. F., & Bruno, J. P. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00009-4 · Cited by 675
Self-citationMcGaughy, J., Kaiser, T., & Sarter, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.247 · Cited by 435 · cited 2×
“Similarly, using an operant task designed to measure sustained attention performance, McGaughy et al. (1996) demonstrated that the loss of cortical cholinergic inputs produced by infusions of the selective cholinergic immunotoxin 192 IgG-saporin into the basal forebrain decreases animals’ ability…”
BackgroundMethodSelf-citationMuir, J. L., Everitt, B. J., & Robbins, T. W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02313.1994 · Cited by 421
Acetylcholine and Choline in Neuronal Tissue Measured by HPLC with Electrochemical Detection
Potter, P. E., Meek, J. L., & Neff, N. H. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb13668.x · Cited by 412
Robinson, T. E., Gorny, G., Mitton, E., & Kolb, B. E. (2001) · Synapse · doi:10.1002/1098-2396(20010301)39:3 · Cited by 411
Self-citationMcGaughy, J. A., & Sarter, M. F. (1995) · Psychopharmacology · doi:10.1007/bf02246109 · Cited by 348
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Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733
Self-citationSarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667
Self-citationPrefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales
Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623
Self-citationMore attention must be paid: The neurobiology of attentional effort
Sarter, M., Gehring, W. J., & Kozak, R. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.002 · Cited by 552
Self-citationHasselmo, M. E., & McGaughy, J. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45015-2 · Cited by 525
Metadata
- Authors
- Arnold, H. M., Burk, J. A., Hodgson, E. M., Sarter, M., & Bruno, J. P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Bruno, J.P
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 114
- Issue
- 2
- Pages
- 451-460
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2096253586
- Cited by
- 195
- References
- 36
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH057436, MH57436)
- National Institute of Neurological Disorders and Stroke (NS37026, R01NS037026)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- acetylcholine release, sustained attention, frontoparietal cortex, cholinergic system, attentional demands, operant responding, fixed-interval schedules, basal forebrain, rats
- MeSH terms
- Acetylcholine, Animals, Attention, Behavior, Animal, Cerebral Cortex, Cholinergic Fibers, Conditioning, Operant, Male, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Rats, Inbred F344, Up-Regulation, Microdialysis, Presynaptic Terminals, Basal Nucleus of Meynert, Rats
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