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Cited by 68Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Operant performance and cortical acetylcholine release: role of response rate, reward density, and non-contingent stimuli

Himmelheber, Anne Marie, Sarter, Martin, Bruno, John P·1997·Cognitive Brain Research
DOI 10.1016/s0926-6410(97)00014-1
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Abstract

The relationship between acetylcholine (ACh) efflux in medial prefrontal cortex (mPFC) and performance in a visual discrimination task and a variable interval (VI) schedule of reinforcement was studied in rats. Animals were pretrained in one of the two tasks and then unilaterally implanted with microdialysis guide cannula into the mPFC. Animals were then dialyzed, during 12 min collection intervals, in the operant chambers prior to task onset and during and after task performance. Each animal was dialyzed for a total of four sessions: two standard task sessions, one session in which a houselight was flashed at 0.5 Hz during the third 12 min block, and an extinction session (always the last session) in which reinforcement was withheld during the final three blocks. Response accuracy in the discrimination task was very high (> 95% correct) and stable across the four blocks with a progressive increase in omissions. The flashing houselight did not affect performance whereas the loss of reinforcement led to an increase in omissions. VI performance was associated with a high number of lever presses and a high reward rate that declined over the four blocks. Again, the flashing houselight did not affect VI performance whereas lever pressing declined markedly during the extinction session. ACh efflux did not change, relative to baseline, during performance in either task, or with the presentation of the flashing houselight or the loss of reinforcement. These data contrast with the changes in cortical ACh efflux observed in situations characterized by the presentation of novel stimuli or changing demands on attentional processing and, therefore, assist in the specification of hypotheses on the cognitive functions of cortical ACh.

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Crossref · 10.1016/s0926-6410(97)00014-1

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  • Increases in ACh release are not observed in animals performing behavioral procedures that control for non-cognitive performance variables, such as lever pressing and reward rates, or the presentation of stimuli and distractors in contexts that do not require attention.

    “These increases in ACh release were not observed in animals performing behavioral procedures that controlled for non-cognitive performance variables, such as lever pressing and reward rates, or the presentation of stimuli and distractors in contexts that do not require attention (e.g., Himmelheber et al, 1997; Arnold et al, 2002).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Himmelheber et al, 1997

  • Attentional performance-associated increases in cortical ACh release are consistently demonstrated by microdialysis.

    “Measures of ACh release in task-performing animals, using microdialysis, consistently demonstrated attentional performance-associated increases in cortical ACh release.”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Himmelheber et al, 1997

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Authors
Himmelheber, A. M., Sarter, M., & Bruno, J. P.
Affiliations
The Ohio State University (US)
Corresponding author
Bruno, John P
ORCID
Venue
Cognitive Brain Research
Publisher
Elsevier BV
Published
1997-07
Volume
6
Issue
1
Pages
23-36
ISSN
0926-6410 (ISSN-L)
DOI
10.1016/s0926-6410(97)00014-1
OpenAlex
W2044466219
Cited by
68
References
45
Citations by year
2026: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2020: 3 · 2019: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cognitive Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag010173-10)
  • National Institute on Aging (R01 AG10173)
  • National Institute of Mental Health (KO2 MH01072, K02MH001072)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
acetylcholine efflux, medial prefrontal cortex, operant performance, response rate, variable-interval schedules, extinction, visual discrimination task, attentional processes
MeSH terms
Acetylcholine, Animals, Conditioning, Operant, Discrimination Learning, Male, Photic Stimulation, Psychomotor Performance, Rats, Inbred BN, Rats, Inbred F344, Reward, Prefrontal Cortex, Rats

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