Increases in cortical acetylcholine release during sustained attention performance in rats
Abstract
Acetylcholine (ACh) efflux in the frontoparietal cortex was studied with in vivo microdialysis while rats performed in an operant task designed to assess sustained attention. Transferring animals from the baseline environment into the operant chambers elicited a robust increase in cortical ACh efflux that persisted throughout the 18-min pre-task period. Subsequent performance in the 36-min sustained attention task was associated with further significant increases in frontoparietal ACh efflux, while the termination of the task resulted in a delayed decline in ACh levels. Upon the 12-min presentation of a visual distracter (flashing houselight, 0.5 Hz) during task performance, animals initially developed a significant response bias to the left lever in the first 6-min distracter block, reflecting a reduction of attentional effort. Under continued conditions of increased attentional demand, performance recovered during the second 6-min distracter block. This return to attentional processing was accompanied by an increase in cortical ACh efflux, suggesting that the augmentation of attentional demand produced by the distracter elicited further increases in ACh release. The enhancement of cortical ACh efflux observed prior to task performance implies the presence of complex relationships between cortical ACh release and anticipatory and/or contextual factors related to operant performance and attentional processing. This finding, along with the further increases in cortical ACh efflux associated with task performance, extends hypotheses regarding the crucial role of cortical cholinergic transmission for attentional functions. Furthermore, the effects of the distracter stimulus provide evidence for a direct relationship between attentional effort and cortical ACh release.
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Distractor stimuli in the sustained attention task should not evoke cholinergic transients.
“In contrast, distractor stimuli in the sustained attention task should not evoke cholinergic transients (Himmelheber et al, 2000; Gill et al, 2000; Howe et al, unpublished results).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Himmelheber et al, 2000
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348 · see citing works
NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES
Bowen, D. M., Smith, C. B., White, P., & DAVISON, A. N. (1976) · Brain · doi:10.1093/brain/99.3.459 · Cited by 1,313 · see citing works
Vasey, M. W., & Thayer, J. F. (1987) · Psychophysiology · doi:10.1111/j.1469-8986.1987.tb00324.x · Cited by 1,063 · see citing works
Cholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948 · see citing works
Neurotransmitter enzyme abnormalities in senile dementia
Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90073-9 · Cited by 724 · see citing works
Cognitive functions of cortical acetylcholine: toward a unifying hypothesis
Sarter, M. F., & Bruno, J. P. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00009-4 · Cited by 662 · see citing works
Self-citationMcGaughy, J., Kaiser, T., & Sarter, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.247 · Cited by 435 · see citing works
Self-citationMcGaughy, J. A., Kaiser, T. E., & Sarter, M. F. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.247 · Cited by 435 · see citing works
Self-citationMuir, J. L., Everitt, B. J., & Robbins, T. W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02313.1994 · Cited by 421 · see citing works
McGaughy, J. A., & Sarter, M. F. (1995) · Psychopharmacology · doi:10.1007/bf02246109 · Cited by 348 · see citing works
Self-citationAcquas, E., Wilson, C., & Fibiger, H. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03089.1996 · Cited by 318 · see citing works
Chiba, A., Bucci, D., Holland, P., & Gallagher, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07315.1995 · Cited by 257 · see citing works
Everitt, B. J., Robbins, T. W., & Muir, J. L. (1995) · Psychopharmacology · doi:10.1007/bf02245253 · Cited by 214 · see citing works
Metherate, R., & Ashe, J. H. (1993) · Synapse · doi:10.1002/syn.890140206 · Cited by 203 · see citing works
Inglis, F. M., & Fibiger, H. C. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00578-s · Cited by 176 · see citing works
McGaughy, J., & Sarter, M. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1519 · Cited by 147 · see citing works
Self-citationMcGaughy, J. A., & Sarter, M. F. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1519 · Cited by 143 · see citing works
Self-citationInglis, F. M., Day, J. C., & Fibiger, H. C. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90342-5 · Cited by 136 · see citing works
Holley, L. A., Turchi, J. N., Apple, C. A., & Sarter, M. F. (1995) · Psychopharmacology · doi:10.1007/bf02246150 · Cited by 130 · see citing works
Self-citationOrsetti, M., Casamenti, F., & Pepeu, G. (1996) · Brain Research · doi:10.1016/0006-8993(96)00292-2 · Cited by 126 · see citing works
Mesulam, M. M. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62112-3 · Cited by 120 · see citing works
Moore, H., Sarter, M. F., & Bruno, J. P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11444-2 · Cited by 103 · see citing works
Self-citationAttention and stimulus processing in the rat
Muir, J. L. (1996) · Cognitive Brain Research · doi:10.1016/0926-6410(96)00008-0 · Cited by 89 · see citing works
Moore, H. M., Stuckman, S. S., Sarter, M. F., & Bruno, J. P. (1995) · Synapse · doi:10.1002/syn.890210407 · Cited by 73 · see citing works
Self-citationMoore, H. M., Sarter, M. F., & Bruno, J. P. (1992) · Brain Research · doi:10.1016/0006-8993(92)91527-l · Cited by 72 · see citing works
Self-citationActivation to acquisition : functional aspects of the basal forebrain cholinergic system
Richardson, R. T. (1991) · Medical Entomology and Zoology · Cited by 70 · see citing works
Himmelheber, A. M., Sarter, M., & Bruno, J. P. (1997) · Cognitive Brain Research · doi:10.1016/s0926-6410(97)00014-1 · Cited by 68 · see citing works
Self-citationJiménez-Capdeville, M. E., & Dykes, R. W. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00439-4 · Cited by 57 · see citing works
Himmelheber, A. M., Fadel, J. R., Sarter, M. F., & Bruno, J. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00097-9 · Cited by 42 · see citing works
Self-citationThiel, C. M., Huston, J. P., & Schwarting, R. K. W. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00961-5 · Cited by 40 · see citing works
Detection of visual signals by rats: effects of signal intensity, event rate, and task type
Bushnell, P. J. (1999) · Behavioural Processes · doi:10.1016/s0376-6357(99)00030-3 · Cited by 37 · see citing works
Functional Implications of Tonic and Phasic Activity Changes in Nucleus Basalis Neurons
Richardson, R. T., & DeLong, M. R. (1991) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-0556-9_6 · Cited by 36 · see citing works
Butt, A. E., Testylier, G., & Dykes, R. W. (1997) · Psychobiology · doi:10.3758/bf03327024 · Cited by 36 · see citing works
In Vivo Neurochemical Correlates of Cognitive Processes: Methodological and Conceptual Challenges
Bruno, J. P., Sorter, M., Arnold, H. M., & Himmelheber, A. M. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.1.25 · Cited by 34 · see citing works
Self-citationDopaminergic modulation of striatal acetylcholine release in rats depleted of dopamine as neonates
Johnson, B. J., & Bruno, J. P. (1995) · Neuropharmacology · doi:10.1016/0028-3908(94)00144-h · Cited by 24 · see citing works
Self-citationGiovanni Laviola, A., & Dell’Omo, G. (1997) · Psychobiology · doi:10.3758/bf03331923 · Cited by 18 · see citing works
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The cognitive neuroscience of sustained attention: where top-down meets bottom-up.
Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194 · see citing works
Self-citationModes and models of forebrain cholinergic neuromodulation of cognition
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Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623 · see citing works
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Polley, D. B., Steinberg, E. E., & Merzenich, M. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3771-05.2006 · Cited by 551 · see citing works
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Giovannini, M. G., Rakovska, A., Benton, R. S., Pazzagli, M., Bianchi, L., & Pepeu, G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00266-4 · Cited by 267 · see citing works
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Reed, A., Riley, J. R., Carraway, R. S., Carrasco, A. E., Perez, C., Jakkamsetti, V., & Kilgard, M. P. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.038 · Cited by 227 · see citing works
Modulators in concert for cognition: Modulator interactions in the prefrontal cortex
Briand, L. A., Gritton, H., Howe, W. M., Young, D. A., & Sarter, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.007 · Cited by 216 · see citing works
Self-citationSpecific basal forebrain-cortical cholinergic circuits coordinate cognitive operations
Záborszky, L., Gombkoto, P., Varsanyi, P., Gielow, M. R., Poe, G., Role, L. W., Ananth, M., Rajebhosale, P., Talmage, D. A., Hasselmo, M. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1676-18.2018 · Cited by 202 · see citing works
Arnold, H. M., Burk, J. A., Hodgson, E. M., Sarter, M., & Bruno, J. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00292-0 · Cited by 195 · see citing works
Self-citationCognitive sequelae of head injury: involvement of basal forebrain and associated structures
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Changes in Acetylcholine Extracellular Levels During Cognitive Processes: Table 1.Preprint
Pepeu, G., & Giovannini, M. G. (2004) · Learning & Memory · doi:10.1101/lm.68104 · Cited by 193 · see citing works
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Newman, E. L., Gupta, K., Climer, J. R., Monaghan, C. K., & Hasselmo, M. E. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00024 · Cited by 185 · see citing works
Bentley, P., Masud Husain, B., & Dolan, R. J. (2004) · Neuron · doi:10.1016/s0896-6273(04)00145-x · Cited by 179 · see citing works
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Self-citationCholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging
Bentley, P., Driver, J., & Dolan, R. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.002 · Cited by 173 · see citing works
Dalley, J. W. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh052 · Cited by 191 · see citing works
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Anderson, K. L., & Ding, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.004 · Cited by 175 · see citing works
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Aïd, S., Vancassel, S., Poumès‐Ballihaut, C., Chalon, S., Guesnet, P., & Lavialle, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300079-jlr200 · Cited by 167 · see citing works
McGaughy, J. A., Everitt, B. J., Robbins, T. W., & Sarter, M. F. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00262-x · Cited by 161 · see citing works
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Sarter, M. F., & Bruno, J. P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.011 · Cited by 148 · see citing works
Self-citationAugmented Prefrontal Acetylcholine Release during Challenged Attentional Performance
Kozak, R., Bruno, J. P., & Sarter, M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi079 · Cited by 144 · see citing works
Self-citationCholinesterase inhibitors and memory
Pepeu, G., & Giovannini, M. G. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.11.018 · Cited by 134 · see citing works
Pupil Dilation Dynamics Track Attention to High-Level Information
Kang, O. E., Huffer, K., & Wheatley, T. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102463 · Cited by 131 · see citing works
Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex
Nelson, C. L., Sarter, M., & Bruno, J. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.007 · Cited by 128 · see citing works
Self-citationParker, M. O., Brock, A. J., Walton, R. T., & Brennan, C. H. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00063 · Cited by 130 · see citing works
CNTRICS final animal model task selection: Control of attention
Lustig, C., Kozak, R., Sarter, M. F., Young, J. W., & Robbins, T. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.009 · Cited by 117 · see citing works
Self-citationParikh, V., Pomerleau, F., Huettl, P., Gerhardt, G. A., Sarter, M., & Bruno, J. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03614.x · Cited by 117 · see citing works
Self-citationWall, P. M., & Messier, C. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00355-2 · Cited by 113 · see citing works
Sarter, M. F., & Bruno, J. P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02004.x · Cited by 113 · see citing works
Self-citationSelective Effects of Cholinergic Modulation on Task Performance during Selective Attention
Furey, M. L., Pietrini, P., Haxby, J. V., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301461 · Cited by 107 · see citing works
Disney, A. A., & Aoki, C. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21616 · Cited by 109 · see citing works
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Eggermann, E., & Feldmeyer, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810062106 · Cited by 104 · see citing works
Zhang, H., Han, T., Zhang, L., Yu, C., De-guang, W., Rahman, K., Qin, L., & Peng, C. Y. (2008) · Phytomedicine · doi:10.1016/j.phymed.2007.12.004 · Cited by 104 · see citing works
Rats and humans paying attention: Cross-species task development for translational research.
Demeter, E., Sarter, M. F., & Lustig, C. (2008) · Neuropsychology · doi:10.1037/a0013712 · Cited by 104 · see citing works
Self-citationCocker, P. J., Hosking, J. G., Benoit, J. R. A., & Winstanley, C. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.30 · Cited by 104 · see citing works
Chiamulera, C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.005 · Cited by 101 · see citing works
Deficits in attentional control: Cholinergic mechanisms and circuitry-based treatment approaches.
Sarter, M. F., & Paolone, G. (2011) · Behavioral Neuroscience · doi:10.1037/a0026227 · Cited by 98 · see citing works
Self-citationColombo, M. L., Sweedler, J. V., & Shen, M. (2015) · Analytical Chemistry · doi:10.1021/ac504151e · Cited by 98 · see citing works
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Borden, P. M., Zhang, P., Shivange, A. V., Marvin, J. S., Cichon, J., Dan, C., Podgorski, K., Figueiredo, A. M. P. D., Novák, O., Tanimoto, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.07.939504 · Cited by 94 · see citing works
Evans, A. K., & Lowry, C. (2007) · CNS drug reviews · doi:10.1111/j.1527-3458.2007.00025.x · Cited by 92 · see citing works
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Grottick, A. J., & Higgins, G. A. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1174-3 · Cited by 82 · see citing works
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Vale-Martı́nez, A., Baxter, M. G., & Eichenbaum, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02153.x · Cited by 58 · see citing works
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Disney, A. A., Aoki, C., & Hawken, M. J. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00188.2012 · Cited by 57 · see citing works
Acetylcholine modulates the temporal dynamics of human theta oscillations during memory
Gedankien, T., Tan, R. J., Qasim, S. E., Moore, H. C., McDonagh, D. L., Jacobs, J., & Lega, B. C. (2023) · Nature Communications · doi:10.1038/s41467-023-41025-y · Cited by 58 · see citing works
Paying attention to smell: cholinergic signaling in the olfactory bulb
Dâ€TMSouza, R. D., & Vijayaraghavan, S. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00021 · Cited by 57 · see citing works
Medalla, M., & Barbas, H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2339-12.2012 · Cited by 57 · see citing works
Atomoxetine facilitates attentional set shifting in adolescent rats
Cain, R. E., Wasserman, M. C., Waterhouse, B. D., & McGaughy, J. A. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.04.003 · Cited by 55 · see citing works
Huang, C., & Hsu, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp161 · Cited by 56 · see citing works
Turchi, J. N., & Sarter, M. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00089-6 · Cited by 56 · see citing works
Self-citationAttention-modulating effects of cognitive enhancers
Levin, E. D., Bushnell, P. J., & Rezvani, A. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.008 · Cited by 54 · see citing works
Interactions between aging and cortical cholinergic deafferentation on attention⋆
Burk, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00315-3 · Cited by 54 · see citing works
Pupillometry as an Objective Measure of Sustained Attention in Young and Older Listeners
Zhao, S., Bury, G., Milne, A. E., & Maria Chait, A. (2019) · Trends in Hearing · doi:10.1177/2331216519887815 · Cited by 55 · see citing works
Kozak, R., Martínez, V., Young, D. A., Brown, H. D., Bruno, J. P., & Sarter, M. F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301352 · Cited by 53 · see citing works
Self-citationNMDA and dopamine interactions in the nucleus accumbens modulate cortical acetylcholine release
Zmarowski, A., Sarter, M., & Bruno, J. P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04333.x · Cited by 52 · see citing works
Self-citationStudy on the sub-regions volume of hippocampus and amygdala in schizophrenia
Zheng, F., Li, C., Zhang, D., Cui, D., Wang, Z., & Qiu, J. (2019) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2019.05.21 · Cited by 51 · see citing works
Berry, A. S., Blakely, R., Sarter, M. F., & Lustig, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.036 · Cited by 47 · see citing works
Self-citationGordon, B. A., Zacks, J. M., Blazey, T., Benzinger, T. L. S., Morris, J. C., Fagan, A. M., Holtzman, D. M., & Balota, D. A. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.019 · Cited by 47 · see citing works
Coetzee, D. D., López, V., & Smith, C. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.11.034 · Cited by 46 · see citing works
Cholinergic-mediated response enhancement in barrel cortex layer V pyramidal neurons
Núñez, Á., Domínguez, S., Buño, W., & de Sevilla, D. F. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00156.2012 · Cited by 46 · see citing works
Zhang, H., Han, T., Yu, C., Rahman, K., Qin, L., & Peng, C. Y. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.2.0016 · Cited by 45 · see citing works
Cholinergic Deafferentation of the Neocortex Using 192 IgG-Saporin Impairs Feature Binding In Rats
Botly, L. C. P., & Rosa, E. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0654-09.2009 · Cited by 44 · see citing works
Repeated pretreatment with amphetamine sensitizes increases in cortical acetylcholine release
Nelson, C. L., Sarter, M. F., & Bruno, J. P. (2000) · Psychopharmacology · doi:10.1007/s002130000494 · Cited by 45 · see citing works
Self-citationKalinchuk, A. V., Porkka‐Heiskanen, T., McCarley, R. W., & Basheer, R. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12766 · Cited by 44 · see citing works
The prominent role of stimulus processing
Furey, M. L. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328348bda5 · Cited by 42 · see citing works
Increased olfactory bulb acetylcholine bi-directionally modulates glomerular odor sensitivity
Bendahmane, M., Ogg, M. C., Ennis, M. J., & Fletcher, M. L. (2016) · Scientific Reports · doi:10.1038/srep25808 · Cited by 42 · see citing works
Disney, A. A., & Reynolds, J. H. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23456 · Cited by 40 · see citing works
“…cortical cholinergic modulation underlies attention (Arnold et al., 2002; Deco and Thiele, 2011; Hasselmo and McGaughy, 2004; Herrero et al., 2008; Himmelheber et al., 2000; McGaughy and Sarter, 1998; Sarter et al., 2005), and it has also been argued that changes in GABAergic inhibition could…”
BackgroundSarter, M., Martinez, V., & Kozak, R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1216-6 · Cited by 41 · see citing works
Self-citationMcCoy, P. A., & McMahon, L. L. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00510.2007 · Cited by 40 · see citing works
Modeling Deficits in Attention, Inhibition, and Flexibility in HAND
Moran, L. M., Booze, R. M., & Mactutus, C. F. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9539-z · Cited by 38 · see citing works
Pelosin, E., Cerulli, C., Ogliastro, C., Lagravinese, G., Mori, L., Bonassi, G., Mirelman, A., Hausdorff, J. M., Abbruzzese, G., Marchese, R., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz072 · Cited by 39 · see citing works
- Authors
- Himmelheber, A. M., Sarter, M., & Bruno, J. P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Bruno, John P
- Venue
- Cognitive Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 9
- Issue
- 3
- Pages
- 313-325
- ISSN
- 0926-6410 (ISSN-L)
- OpenAlex
- W2063060972
- Cited by
- 261
- References
- 35
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 13 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 17 · 2013: 13 · 2012: 13
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cognitive Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH057436, MH57436)
- National Institute of Neurological Disorders and Stroke (NS32938, NS37026, R01NS037026, R01NS032938)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- acetylcholine release, sustained attention, frontoparietal cortex, cholinergic neurotransmission, attentional effort, response bias, rats
- MeSH terms
- Acetylcholine, Animals, Attention, Cerebral Cortex, Conditioning, Operant, Habituation, Psychophysiologic, Male, Synaptic Transmission, Psychomotor Performance, Rats, Inbred F344, Prosencephalon, Microdialysis, Rats
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