Augmented Prefrontal Acetylcholine Release during Challenged Attentional Performance
Abstract
Previous research has demonstrated that attentional performance depends on the integrity of the cortical cholinergic input system and that such performance is associated with increases in cortical acetylcholine (ACh) release. The present experiment tested the hypothesis that the attentional impairments produced by bilateral basal forebrain infusions of the NMDA receptor antagonist DL-2-amino-5-phosphonovaleric acid (APV) are associated with attenuation of performance-associated increases in ACh release. Rats were trained in a sustained attention task and equipped with three guide cannula for the bilateral infusion of the NMDA receptor antagonist APV (0, 3, 20 nmol) and for the insertion of a dialysis probe into the medial prefrontal cortex (mPFC). APV or vehicle was infused remotely following completion of the first of five blocks of trials. During the first block, attentional performance was associated with a 140% increase in ACh efflux. Infusions of APV decreased the animals' ability to detect signals and augmented the increases in ACh efflux observed prior to infusions. These data indicate a dissociation between levels of attentional performance and increases in mPFC ACh release. Augmentation of performance-associated increases in mPFC cholinergic transmission is hypothesized to mediate the increased demands on attentional 'effort' that are required to maintain performance under challenging conditions.
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Mesolimbic systems selectively and tonically influence cholinergic neurotransmission of prefrontal inputs and thereby gate prefrontal glutamatergic-cholinergic interactions as a function of the motivation to perform, particularly in interaction with performance challenges.
“Mesolimbic systems selectively and tonically influence cholinergic neurotransmission of prefrontal inputs and thereby gate prefrontal glutamatergic-cholinergic interactions as a function of the motivation to perform, particularly in interaction with performance challenges (Kozak et al 2006).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Kozak et al 2006
Prefrontal muscarinic recruitment of efferent circuitry may mediate top-down effects to combat performance decay from time-on-task and distractors.
“Such prefrontal, muscarinic recruitment of efferent circuitry may mediate top-down effects in order to, for example, combat performance decay as a result of time-on-task and other performance challenges, such as distractors (Gill et al, 2000; Kozak et al, 2006; Sarter et al, 2006).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Kozak et al, 2006
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- Authors
- Kozak, R., Bruno, J. P., & Sarter, M.
- Affiliations
- University of Michigan (US)
- The Ohio State University (US)
- Corresponding author
- Kozak, Rouba
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-23
- Volume
- 16
- Issue
- 1
- Pages
- 9-17
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2145380587
- Cited by
- 144
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 8
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH063114, K02MH001072, MH63114)
- National Institute of Neurological Disorders and Stroke (NS37026, R01NS037026)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- acetylcholine release, medial prefrontal cortex, sustained attention, NMDA receptor antagonists, APV, cholinergic neurotransmission, attentional effort, signal detection
- MeSH terms
- Acetylcholine, Adaptation, Physiological, Animals, Attention, Behavior, Animal, Male, Synaptic Transmission, Psychomotor Performance, Rats, Inbred F344, Valine, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Rats
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