Cited by 284Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

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A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine

Avena, N.M., Hoebel, B.G.·2003·Neuroscience

DOI 10.1016/s0306-4522(03)00502-5

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Abstract

Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (day 0), animals were maintained on a cyclic diet of 12-h deprivation followed by 12-h access to 10% sucrose solution and chow pellets (12 h access starting 4 h after onset of the dark period) for 21 days. Locomotor activity was measured again for 30 min at the beginning of days 1 and 21 of sugar access. Beginning on day 22, all rats were maintained on ad libitum chow. Nine days later locomotor activity was measured in response to a single low dose of amphetamine (0.5 mg/kg). The animals that had experienced cyclic sucrose and chow were hyperactive in response to amphetamine compared with four control groups (ad libitum 10% sucrose and chow followed by amphetamine injection, cyclic chow followed by amphetamine injection, ad libitum chow with amphetamine, or cyclic 10% sucrose and chow with a saline injection). These results suggest that a diet comprised of alternating deprivation and access to a sugar solution and chow produces bingeing on sugar that leads to a long lasting state of increased sensitivity to amphetamine, possibly due to a lasting alteration in the dopamine system.

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The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,295
Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis
Hernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627
Self-citation
Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence
Colantuoni, C., Rada, P. V., McCarthy, J., Patten, C. S., Avena, N. M., Chadeayne, A., & Hoebel, B. G. (2002) · Obesity Research · doi:10.1038/oby.2002.66 · Cited by 544
Self-citation
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471
Self-citation
Opioid modulation of appetite
Morley, J. E., Levine, A. S., Yim, G. K. W., & Lowy, M. T. (1983) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(83)90020-9 · Cited by 453
Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered “Wanting” for Sucrose Reward
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436
Norepinephrine-Dopamine Interactions and Behavior
Antelman, S. M., & Caggiula, A. R. (1977) · Science · doi:10.1126/science.841304 · Cited by 409
Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.
Henry, D. J., & White, F. J. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20496-7 · Cited by 365

Show all 43 references

Research works printed but not linked: 1

Mitchell, 1991, Comorbidity and medical complications of bulimia nervosa, J Clin Psychiatry, 52, 13

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Self-citation
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Kosheleff, A. R., Araki, J., Hsueh, J., Le, A., Quizon, K., Ostlund, S. B., Maidment, N. T., & Murphy, N. P. (2017) · Appetite · doi:10.1016/j.appet.2017.12.009 · Cited by 15
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Authors: Avena, N. M., & Hoebel, B. G.
Affiliations: Princeton University (US)
Corresponding author: Hoebel, B.G.
ORCID: Avena, N.M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2003-11
Volume: 122
Issue: 1
Pages: 17-20
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/s0306-4522(03)00502-5
OpenAlex: W2095178182
Cited by: 284
References: 43
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 12 · 2015: 18 · 2014: 19 · 2013: 11 · 2012: 24
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH65024, R21MH065024)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: binge eating, amphetamine, locomotor activity, dopaminergic system, sucrose, female rats
MeSH terms: Amphetamine, Central Nervous System Stimulants, Animals, Behavior, Animal, Female, Hyperkinesis, Locomotion, Sucrose, Dopamine Agents, Rats, Sprague-Dawley, Substance-Related Disorders, Amphetamine-Related Disorders, Rats

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A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine

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