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A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine
Abstract
Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (day 0), animals were maintained on a cyclic diet of 12-h deprivation followed by 12-h access to 10% sucrose solution and chow pellets (12 h access starting 4 h after onset of the dark period) for 21 days. Locomotor activity was measured again for 30 min at the beginning of days 1 and 21 of sugar access. Beginning on day 22, all rats were maintained on ad libitum chow. Nine days later locomotor activity was measured in response to a single low dose of amphetamine (0.5 mg/kg). The animals that had experienced cyclic sucrose and chow were hyperactive in response to amphetamine compared with four control groups (ad libitum 10% sucrose and chow followed by amphetamine injection, cyclic chow followed by amphetamine injection, ad libitum chow with amphetamine, or cyclic 10% sucrose and chow with a saline injection). These results suggest that a diet comprised of alternating deprivation and access to a sugar solution and chow produces bingeing on sugar that leads to a long lasting state of increased sensitivity to amphetamine, possibly due to a lasting alteration in the dopamine system.
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“Cross-sensitization and the resulting hyper-responsivity of dopaminergic systems also occurs between drugs of abuse and natural rewards (Avena & Hoebel, 2003)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Avena & Hoebel, 2003
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Metadata
- Authors
- Avena, N. M., & Hoebel, B. G.
- Affiliations
- Princeton University (US)
- Corresponding author
- Hoebel, B.G.
- ORCID
- Avena, N.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 122
- Issue
- 1
- Pages
- 17-20
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2095178182
- Cited by
- 284
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 12 · 2015: 18 · 2014: 19 · 2013: 11 · 2012: 24
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH65024, R21MH065024)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- binge eating, amphetamine, locomotor activity, dopaminergic system, sucrose, female rats
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Animals, Behavior, Animal, Female, Hyperkinesis, Locomotion, Sucrose, Dopamine Agents, Rats, Sprague-Dawley, Substance-Related Disorders, Amphetamine-Related Disorders, Rats
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