The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons
Abstract
To investigate the effects of an ethologically-relevant stressor on central and peripheral release of arginine vasopressin and oxytocin, we forced adult male Wistar rats to swim for 10 min and simultaneously measured the release of the two peptides (i) within the hypothalamic supraoptic and paraventricular nuclei (by means of the microdialysis technique) and (ii) into the blood (by chronically-implanted jugular venous catheters). Forced swimming caused a significant rise in the release of arginine vasopressin and oxytocin within both the supraoptic nuclei (four-fold and three-fold, respectively) and the paraventricular nuclei (three-fold and four- to five-fold, respectively). Release patterns measured before, during and after repeated stress exposure on three consecutive days indicated that, at the level of the hypothalamus, the two neuropeptides are critically involved in the rats' stress response in a peptide-, locus- and stress-specific manner. Particularly, despite a general reduction of the recovery of the microdialysis probes over the time, the release of arginine vasopressin within the paraventricular nuclei and of oxytocin within the supraoptic nuclei tended to increase upon repeated stress exposure. Measurement of plasma peptide concentrations revealed that the central release of oxytocin was accompanied by a secretion of this peptide into the systemic circulation. In contrast, arginine vasopressin, assayed in the same plasma samples, failed to respond to the stressor. The latter finding is consistent with a dissociated release of the neuropeptide from different parts of a single neuron (soma/dendrites vs axon terminals). It provides evidence that under physiological conditions plasma hormone levels do not necessarily reflect the secretory activity of central components of the respective neuropeptidergic system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Stress affects both central and peripheral secretion of oxytocin-but while swim stress in rats increases oxytocin release in the hypothalamus and into plasma (82), novelty stress increases CSF but not plasma concentrations (83).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [82]
In the citing paper
“Because the links between central and peripheral OT are not fully understood, it is not clear whether plasma levels reflect central activity of the system, although studies in both humans and animals point to coordination between central and peripheral levels (Burri et al., 2008; Wotjak et al., 1998).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Wotjak et al., 1998
In the citing paper
“From the functional side, Wotjak et al. (1998) demonstrated that peripheral and central concentrations of oxytocin are simultaneously raised during forced swimming stress, suggesting a coordinated release of oxytocin into central and peripheral areas.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Wotjak et al., 1998
In the citing paper
“Indeed, although rodent studies show oxytocin release in response to non-social stressors (e.g., Wotjak et al., 1998), few human—or non-human primate—studies have done so (see Sanders et al., 1990).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Wotjak et al., 1998
In the citing paper
“Although the relationship between central and peripheral OT levels is not fully understood, both animal (29,66) and recent human (39) studies suggest that central and peripheral activity of the oxytocinergic system is coordinated.”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [66]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Mechanisms of stress: A dynamic overview of hormonal and behavioral homeostasis
Johnson, E. O., Kamilaris, T. C., Chrousos, G. P., & Gold, P. W. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80175-7 · Cited by 899
The Role of Blood Osmolality and Volume in Regulating Vasopressin Secretion in the Rat
Dunn, F. L., Brennan, T. J., Nelson, A. E., & Robertson, G. L. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107521 · Cited by 687
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90091-2 · Cited by 446
Hatton, G. I. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90017-b · Cited by 439
Determination of Brain Interstitial Concentrations by Microdialysis
Benveniste, H., Hansen, A. J., & Ottosen, N. S. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07252.x · Cited by 403
Research works printed but not linked: 1
- Hermes, 1996, Inhibitory action of vasopressin on neurons of the rat hypothalamic paraventricular nucleus, Soc. Neurosci. Abstr., 22, 807.16
Cited by
Sorted by citations
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Metadata
- Authors
- Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M.
- Affiliations
- Max Planck Society (DE)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Engelmann, M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 85
- Issue
- 4
- Pages
- 1209-1222
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1999753672
- Cited by
- 345
- References
- 70
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 18 · 2018: 17 · 2017: 15 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 17 · 2012: 18
- FWCI
- 18.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, oxytocin, forced swim stress, repeated stress exposure, supraoptic nucleus, hypothalamic paraventricular nucleus, neuropeptide release, plasma hormone levels, peptidergic neurons, stress response
- MeSH terms
- Animals, Central Nervous System, Corticosterone, Corticotropin-Releasing Hormone, Male, Neurons, Neuropeptides, Osmolar Concentration, Oxytocin, Peripheral Nerves, Stress, Psychological, Swimming, Vasopressins, Rats, Wistar, Microdialysis, Lactic Acid, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
