Cited by 345Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons

Wotjak, C.T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., Engelmann, M.·1998·Neuroscience

Open this paper in CoChat — free account

Abstract

To investigate the effects of an ethologically-relevant stressor on central and peripheral release of arginine vasopressin and oxytocin, we forced adult male Wistar rats to swim for 10 min and simultaneously measured the release of the two peptides (i) within the hypothalamic supraoptic and paraventricular nuclei (by means of the microdialysis technique) and (ii) into the blood (by chronically-implanted jugular venous catheters). Forced swimming caused a significant rise in the release of arginine vasopressin and oxytocin within both the supraoptic nuclei (four-fold and three-fold, respectively) and the paraventricular nuclei (three-fold and four- to five-fold, respectively). Release patterns measured before, during and after repeated stress exposure on three consecutive days indicated that, at the level of the hypothalamus, the two neuropeptides are critically involved in the rats' stress response in a peptide-, locus- and stress-specific manner. Particularly, despite a general reduction of the recovery of the microdialysis probes over the time, the release of arginine vasopressin within the paraventricular nuclei and of oxytocin within the supraoptic nuclei tended to increase upon repeated stress exposure. Measurement of plasma peptide concentrations revealed that the central release of oxytocin was accompanied by a secretion of this peptide into the systemic circulation. In contrast, arginine vasopressin, assayed in the same plasma samples, failed to respond to the stressor. The latter finding is consistent with a dissociated release of the neuropeptide from different parts of a single neuron (soma/dendrites vs axon terminals). It provides evidence that under physiological conditions plasma hormone levels do not necessarily reflect the secretory activity of central components of the respective neuropeptidergic system.

Integrity signals

Registry

Crossref · 10.1016/s0306-4522(97)00683-0

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Mechanisms of stress: A dynamic overview of hormonal and behavioral homeostasis
Johnson, E. O., Kamilaris, T. C., Chrousos, G. P., & Gold, P. W. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80175-7 · Cited by 899
The Role of Blood Osmolality and Volume in Regulating Vasopressin Secretion in the Rat
Dunn, F. L., Brennan, T. J., Nelson, A. E., & Robertson, G. L. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107521 · Cited by 687
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90091-2 · Cited by 446
Emerging concepts of structure-function dynamics in adult brain: The hypothalamo-neurohypophysial system
Hatton, G. I. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90017-b · Cited by 439
Determination of Brain Interstitial Concentrations by Microdialysis
Benveniste, H., Hansen, A. J., & Ottosen, N. S. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07252.x · Cited by 403

Show all 70 references

Research works printed but not linked: 1

Hermes, 1996, Inhibitory action of vasopressin on neurons of the rat hypothalamic paraventricular nucleus, Soc. Neurosci. Abstr., 22, 807.16

Sorted by citations

The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 978
Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact
Feldman, R., Gordon, I., Schneiderman, I., Weisman, O., & Zagoory-Sharon, O. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.013 · Cited by 638
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595
Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior
Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 569
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Oxytocin and the development of parenting in humans
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.005 · Cited by 469
Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452
The hypothalamic-neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: an old concept revisited
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450
Oxytocin Attenuates Stress-Induced c-fos mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity
Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408
Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402
Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387
Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression
Skrundz, M., Bolten, M., Nast, I., Hellhammer, D. H., & Meinlschmidt, G. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.74 · Cited by 349
Dendritic Release of Vasopressin and Oxytocin
Ludwig (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00279.x · Cited by 342
Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles
Grippo, A. J., Gerena, D., Huang, J., Kumar, N., Shah, M., Ughreja, R., & Sue Carter, C. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.004 · Cited by 336
Anxiety and stress responses in female oxytocin deficient mice
Amico, J. A., Mantella, R. C., Vollmer, R. R., & Li, X. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01161.x · Cited by 327
Oxytocin: Behavioral Associations and Potential as a Salivary Biomarker
SUE CARTER, C., POURNAJAFI‐NAZARLOO, H., KRAMER, K. M., ZIEGLER, T. E., WHITE‐TRAUT, R., BELLO, D., & SCHWERTZ, D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1384.006 · Cited by 323
Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 333
“Because the links between central and peripheral OTare not fully understood, it is not clear whether plasma levels reflect central activity of the system, although studies in both humans and animals point to coordination between central and peripheral levels (Burri et al., 2008; Wotjak et al., 1998).”
Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295
No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain
Slattery, D. A., & Neumann, I. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145896 · Cited by 293
Brain oxytocin inhibits the (re)activity of the hypothalamo–pituitary–adrenal axis in male rats: involvement of hypothalamic and limbic brain regions
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283
The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis
Valstad, M., Alvares, G. A., Egknud, M., Matziorinis, A. M., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.017 · Cited by 277
Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study
Jong, T. R. D., Menon, R., Bludau, A., Grund, T., Biermeier, V., Klampfl, S. M., Jurek, B., Bosch, O. J., Hellhammer, J., & Neumann, I. D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.027 · Cited by 250
The cross-generation transmission of oxytocin in humans
Feldman, R., Gordon, I., & Zagoory-Sharon, O. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.005 · Cited by 256
Oxytocin and cortisol in romantically unattached young adults: associations with bonding and psychological distress
Gordon, I., Zagoory‐Sharon, O., Schneiderman, I., Leckman, J. F., Weller, A., & Feldman, R. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00649.x · Cited by 232
Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits
Baribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 241
Evidence of dysregulated peripheral oxytocin release among depressed women
Cyranowski, J. M., Hofkens, T. L., Frank, E., Seltman, H., Cai, H.-M., & Amico, J. A. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318188ade4 · Cited by 220
Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212
Talking back: dendritic neurotransmitter release
Ludwig, M., & Pittman, Q. J. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00072-9 · Cited by 210
Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children
Carson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196
Hyper‐Reactive Hypothalamo‐Pituitary‐Adrenocortical Axis in Rats Bred for High Anxiety‐Related Behaviour
Landgraf, Wigger, Holsboer, & Neumann (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00342.x · Cited by 203
Release of Oxytocin in the Rat Central Amygdala Modulates Stress-Coping Behavior and the Release of Excitatory Amino Acids
Ebner, K., Bosch, O. J., Krömer, S. A., Singewald, N., & Neumann, I. D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300607 · Cited by 205
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I
Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 201
Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation
Grippo, A. J., Cushing, B. S., & Carter, C. S. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802f054b · Cited by 196
Brain oxytocin: how puzzle stones from animal studies translate into psychiatry
Grinevich, V., & Neumann, I. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0802-9 · Cited by 201
Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review
Crockford, C., Deschner, T., Ziegler, T. E., & Wittig, R. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00068 · Cited by 187
Challenges for measuring oxytocin: the blind men and the elephant?
MacLean, E. L., Wilson, S. R., Martin, W. L., Davis, J. M., Nazarloo, H. P., & Carter, C. S. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.018 · Cited by 183
A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism
Parker, K. J., Oztan, O., Libove, R. A., Mohsin, N., Karhson, D. S., Sumiyoshi, R. D., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau7356 · Cited by 185
Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181
Why inspiring stories make us react: the neuroscience of narrative.
Zak, P. J. (2015) · PubMed Central · Cited by 171
Advances in human oxytocin measurement: challenges and proposed solutions
Tabak, B. A., Leng, G., Szeto, A., Parker, K. J., Verbalis, J. G., Ziegler, T. E., Lee, M. R., Neumann, I. D., & Mendez, A. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01719-z · Cited by 170
Emotional Stress Triggers Intrahypothalamic But Not Peripheral Release of Oxytocin in Male Rats
Engelmann, Ebner, Landgraf, Holsboer, & Wotjak (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00403.x · Cited by 170
Self-citation
Chapter 10 Alterations in behavioral and neuroendocrine stress coping strategies in pregnant, parturient and lactating rats
Neumann, I. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33011-x · Cited by 169
Neuroendocrine and Behavioural Responses to Exposure to an Infant in Male Prairie Voles
Kenkel, W. M., Paredes, J., Yee, J. R., Pournajafi‐Nazarloo, H., Bales, K. L., & Carter, C. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02301.x · Cited by 164
Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain
Keck, M. E., Sillaber, I., Ebner, K., Welt, T., Toschi, N., Kaehler, S. T., Singewald, N., Philippu, A., Elbel, G. K., Wotjak, C. T., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00243.x · Cited by 164
Stimuli and consequences of dendritic release of oxytocin within the brain
Neumann, I. D. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351252 · Cited by 161
Oxytocin, cortisol, and triadic family interactions
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.08.008 · Cited by 158
Monetary sacrifice among strangers is mediated by endogenous oxytocin release after physical contact
MORHENN, V, PARK, J., PIPER, E., & ZAK, P. (2008) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2008.04.004 · Cited by 158
Innovative Approaches for the Treatment of Depression: Targeting the HPA Axis
THOMSON, F. J., & Craighead, M. W. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9518-3 · Cited by 158
Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: Implications for postpartum mood disorder
Bosch, O. J., Müsch, W., Bredewold, R., Slattery, D. A., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.012 · Cited by 155
Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gilleen, J., Sardella, A., Cappucciati, M., Palombini, E., Dell’Osso, L., Caverzasi, E., Politi, P., et al. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.117 · Cited by 149
“Axonal and dendritic/soma release may be independently regulated by the MCNs through inhibitory mechanisms – mediated by corticosterone, GABA, endogenous opioids, the atrial natriuretic peptide and ADH itself – which selectively block the peripheral secretion (Wotjak et al., 1998).”
Chronic stress plasticity in the hypothalamic paraventricular nucleus
Herman, J. P., Flak, J. N., & Jankord, R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00429-9 · Cited by 152
Studies on the neuroendocrine role of serotonin.
Jørgensen, H. S. (2007) · PubMed · Cited by 144
A Comparative Study on Alcohol‐Preferring Rat Lines: Effects of Deprivation and Stress Phases on Voluntary Alcohol Intake
Vengeliene, V., Siegmund, S., Singer, M. V., Sinclair, J. D., Li, T., & Spanagel, R. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000075829.81211.0c · Cited by 142
The interplay between oxytocin and the CRF system: regulation of the stress response
Winter, J. J., & Jurek, B. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2866-2 · Cited by 145
Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence
Pierrehumbert, B., Torrisi, R., Laufer, D., Halfon, O., Ansermet, F., & Beck Popovic, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.016 · Cited by 139
Oxytocin facilitates accurate perception of competition in men and kinship in women
Fischer-Shofty, M., Levkovitz, Y., & Shamay-Tsoory, S. G. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr100 · Cited by 132
Oxytocin and social functioning
Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/cjones · Cited by 132
A meta-analytic review of the correlation between peripheral oxytocin and cortisol concentrations
Brown, C. A., Cardoso, C., & Ellenbogen, M. A. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.11.001 · Cited by 133
Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence
Bosch, O. J., Krömer, S. A., Brunton, P. J., & Neumann, I. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.028 · Cited by 134
Influence of Age at Drinking Onset on Long‐Term Ethanol Self‐Administration With Deprivation and Stress Phases
Siegmund, S., Vengeliene, V., Singer, M. V., & Spanagel, R. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000171928.40418.46 · Cited by 127
Oxytocin levels in saliva correlate better than plasma levels with concentrations in the cerebrospinal fluid of patients in neurocritical care
Martin, J., Kagerbauer, S. M., Gempt, J., Podtschaske, A., Hapfelmeier, A., & Schneider, G. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12596 · Cited by 122
Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men
Opacka‐Juffry, J., & Mohiyeddini, C. (2011) · Stress · doi:10.3109/10253890.2011.560309 · Cited by 128
Brain mechanisms underlying emotional alterations in the peripartum period in rats
Neumann, I. D. (2003) · Depression and Anxiety · doi:10.1002/da.10070 · Cited by 121
Oxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 123
Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum
Brandtzaeg, O. K., Johnsen, E., Røberg‐Larsen, H., Seip, K. F., MacLean, E. L., Gesquiere, L. R., Leknes, S., Lundanes, E., & Wilson, S. R. (2016) · Scientific Reports · doi:10.1038/srep31693 · Cited by 125
Oxytocin and vasopressin are dysregulated in Williams Syndrome, a genetic disorder affecting social behavior
Dai, L., Carter, C. S., Ying, J., Bellugi, U., Pournajafi-Nazarloo, H., & Korenberg, J. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038513 · Cited by 119
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00154 · Cited by 126
Separation Anxiety, Attachment and Inter-Personal Representations: Disentangling the Role of Oxytocin in the Perinatal Period
Eapen, V., Dadds, M. R., Barnett, B. E. W., Kohlhoff, J. R., Khan, F., Radom, N., & Silove, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107745 · Cited by 123
Adult attachment representations predict cortisol and oxytocin responses to stress
Pierrehumbert, B., Torrisi, R., Ansermet, F., Borghini, A., & Halfon, O. (2012) · Attachment & Human Development · doi:10.1080/14616734.2012.706394 · Cited by 115
Oxytocin Links Mothering Received, Mothering Bestowed and Adult Stress Responses
Pedersen, C. A., & Boccia, M. L. (2002) · Stress · doi:10.1080/1025389021000037586 · Cited by 120
Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat.
Frank, E., Salchner, P., Aldag, J. M., Salomé, N., Singewald, N., Landgraf, R., & Wigger, A. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.1.60 · Cited by 112
Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus
Smith, A. S., Tabbaa, M., Lei, K., Eastham, P., Butler, M. J., Linton, L., Altshuler, R., Liu, Y., & Wang, Z. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.017 · Cited by 113
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113
A Preliminary Study of the Effects of a Single Session of Swedish Massage on Hypothalamic–Pituitary–Adrenal and Immune Function in Normal Individuals
Rapaport, M. H., Schettler, P. J., & Bresee, C. J. (2010) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0634 · Cited by 107
Stress-Induced Elevation of Oxytocin in Maltreated Children: Evolution, Neurodevelopment, and Social Behavior
Seltzer, L. J., Ziegler, T. E., Connolly, M. J., Prososki, A. R., & Pollak, S. D. (2013) · Child Development · doi:10.1111/cdev.12136 · Cited by 121
A comparison of methods to measure central and peripheral oxytocin concentrations in human and non-human primates
Lefevre, A., Mottolese, R., Dirheimer, M., Mottolese, C., Duhamel, J.-R., & Sirigu, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17674-7 · Cited by 105
A brief history of oxytocin and its role in modulating psychostimulant effects
Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105
Hypothalamic oxytocin mediates adaptation mechanism against chronic stress in rats
Zheng, J., Babygirija, R., Bülbül, M., Cerjak, D., Ludwig, K., & Takahashi, T. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00483.2009 · Cited by 104
Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats
Juif, P.-E., & Poisbeau, P. (2013) · Pain · doi:10.1016/j.pain.2013.05.003 · Cited by 101
Maternal depression impacts child psychopathology across the first decade of life: Oxytocin and synchrony as markers of resilience
Priel, A., Djalovski, A., Zagoory‐Sharon, O., & Feldman, R. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12880 · Cited by 106
Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampus
de Groote, L., & Linthorst, A. C. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.030 · Cited by 100
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100
Oxytocin Increases Glucose Uptake in Neonatal Rat Cardiomyocytes
Florian, M., Jankowski, M., & Gutkowska, J. (2009) · Endocrinology · doi:10.1210/en.2009-0624 · Cited by 104
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99
Oxytocin is associated with infant-care behavior and motivation in cooperatively breeding marmoset monkeys
Finkenwirth, C., Martins, E. G., Deschner, T., & Burkart, J. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.008 · Cited by 98
A Role for the Androgen Metabolite, 5α‐Androstane‐3β,17β‐Diol, in Modulating Oestrogen Receptor β‐Mediated Regulation of Hormonal Stress Reactivity
Handa, R. J., Weiser, M. J., & Zuloaga, D. G. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01840.x · Cited by 96
Effects of social exclusion on emotions and oxytocin and cortisol levels in patients with chronic depression
Jobst, A., Sabass, L., Palagyi, A., Bauriedl-Schmidt, C., Mauer, M. C., Sarubin, N., Buchheim, A., Renneberg, B., Falkai, P., Zill, P., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.11.001 · Cited by 94
Behavioural impact of intraseptally released vasopressin and oxytocin in rats
Englemann, M., Wotjak, C. T., Ebner, K., & Landgraf, R. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00015.x · Cited by 94
Self-citation
Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
Cohen, H., Kaplan, Z., Kozlovsky, N., Gidron, Y., Matar, M. A., & Zohar, J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02003.x · Cited by 94
Oxytocin and Major Depressive Disorder: Experimental and Clinical Evidence for Links to Aetiology and Possible Treatment
Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94
Stress and the brain: Solving the puzzle using microdialysis
Linthorst, A. C. E., & Reul, J. M. H. M. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.09.019 · Cited by 98

Authors: Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M.
Affiliations: Max Planck Society (DE)
Max Planck Institute of Psychiatry (DE)
Corresponding author: Engelmann, M.
ORCID: Wotjak, C.T.
Engelmann, M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1998-08
Volume: 85
Issue: 4
Pages: 1209-1222
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/s0306-4522(97)00683-0
OpenAlex: W1999753672
Cited by: 345
References: 70
Citations by year: 2026: 1 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 18 · 2018: 17 · 2017: 15 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 17 · 2012: 18
FWCI: 18.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: vasopressin, oxytocin, forced swim stress, repeated stress exposure, supraoptic nucleus, hypothalamic paraventricular nucleus, neuropeptide release, plasma hormone levels, peptidergic neurons, stress response
MeSH terms: Animals, Central Nervous System, Corticosterone, Corticotropin-Releasing Hormone, Male, Neurons, Neuropeptides, Osmolar Concentration, Oxytocin, Peripheral Nerves, Stress, Psychological, Swimming, Vasopressins, Rats, Wistar, Microdialysis, Lactic Acid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks