Differential effects of emotional and physical stress on the central and peripheral secretion of neurohypophysial hormones in male rats
Abstract
The effects of various stressful conditions on the levels of oxytocin (OT) and vasopressin (VP) in plasma and cisternal cerebrospinal fluid (CSF) of male rats were investigated. Three experimental models were used: exposure to a novel environment for 5 min, immobilization for 15 min, and ether inhalation for 10 min resulting in anaesthesia. Novelty and immobilization induced a slight but significant increase in OT levels in the CSF immediately after the stress. The effect of ether was considerably more pronounced. The concentration of VP in the CSF was elevated only by ether stress. In plasma, the level of OT was increased immediately following immobilization and ether stress but not after novelty stress, whereas VP only showed a delayed response 20 min after immobilization. These results indicate a rapid preferential release of OT in the periphery in response to physical and pharmacological stress. In addition, they provide evidence that release of OT into the CSF is triggered by physical, pharmacological as well as emotional stress, while the central release of VP is rather resistant to emotional stress. The data suggest that OT is a stress hormone in the central nervous system.
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Stress affects both central and peripheral oxytocin secretion, but in rats swim stress increases hypothalamic and plasma oxytocin, whereas novelty stress increases CSF but not plasma oxytocin.
“Stress affects both central and peripheral secretion of oxytocin-but while swim stress in rats increases oxytocin release in the hypothalamus and into plasma (82), novelty stress increases CSF but not plasma concentrations (83).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [83]
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INFLUÊNCIA DAS VARIAÇÕES DE CUIDADO MATERNO NA REATIVIDADE AO ESTRESSE DE RATOS NO PERÍODO NEONATAL
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- Authors
- Iványi, T., Wiegant, V. M., & de Wied, D.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Wiegant, V.M.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 48
- Issue
- 13
- Pages
- 1309-1316
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2039008178
- Cited by
- 49
- References
- 38
- Citations by year
- 2023: 1 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, neurohypophyseal hormones, stress, emotional stress, physical stress, novel environment, restraint stress, ether anesthesia, cerebrospinal fluid, plasma hormone levels, stress hormones
- MeSH terms
- Animals, Male, Oxytocin, Pituitary Gland, Posterior, Radioimmunoassay, Rats, Inbred Strains, Stress, Physiological, Vasopressins, Rats
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