The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
Abstract
The relationship between immune activation and the development of early depressive symptoms were studied in 33 cancer patients undergoing cytokine therapy. Patients were treated either with subcutaneous IL-2 administered alone (n=13) or in association with IFN-alpha (n=5), or with IFN-alpha alone administered subcutaneously at low doses (n=5) or intravenously at high doses (n=10). The intensity of depressive symptoms was assessed during a clinical interview carried out before the start of cytokine therapy and five days later using the Montgomery and Asberg Depression Rating Scale (MADRS). On the same days, blood samples were collected for each patient to measure serum concentrations of cytokines (IL-6, IL-10, IL-1ra) and cytokine-receptors (sIL-2R, LIF-R). Results showed that patients treated with IL-2 or IL-2+IFN-alpha displayed concomitant mood symptoms and increased serum cytokine levels during treatment. In these patients, the intensity of depressive symptoms at endpoint was positively correlated with the increases measured in serum levels of IL-10 between baseline and endpoint. IL-10 is an anti-inflammatory cytokine that is produced in response to the production of pro-inflammatory cytokines, and thereby reflects an inflammatory response. These results support the hypothesis of close relationship between depressive symptoms and the activation of the cytokine network.
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“Humans who are treated for cancer and hepatitis C with high doses of pro-inflammatory cytokines also demonstrate these symptoms and are at high risk for developing MDD.[12,13]”
From SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: Research Article: Suicidal Ideation and Inflammation (2013) · cites this paper as [12]
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Items 201–201 of 201
Ma, H., Wei, F., Zhao, M., & Shen, X. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-10939-w
Metadata
- Authors
- Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., & Neveu, P. J.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Capuron, Lucile
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 26
- Issue
- 8
- Pages
- 797-808
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2047987784
- Cited by
- 201
- References
- 35
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 12 · 2017: 6 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- immune activation, depressive symptoms, cancer patients, interleukin-2, interferon-alpha, cytokine therapy, IL-10, serum cytokines, soluble interleukin-2 receptor, inflammation, mood disorders
- MeSH terms
- Affect, Aged, Carcinoma, Renal Cell, Depression, Female, Humans, Immunity, Interleukin-2, Kidney Neoplasms, Male, Middle Aged, Cytokines, Interferon-alpha
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