Cited by 201Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

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Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy

Capuron, Lucile, Ravaud, Alain, Gualde, Norbert, Bosmans, Eugene, Dantzer, Robert, Maes, Michael, Neveu, Pierre J·2001·Psychoneuroendocrinology

DOI 10.1016/s0306-4530(01)00030-0

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Abstract

The relationship between immune activation and the development of early depressive symptoms were studied in 33 cancer patients undergoing cytokine therapy. Patients were treated either with subcutaneous IL-2 administered alone (n=13) or in association with IFN-alpha (n=5), or with IFN-alpha alone administered subcutaneously at low doses (n=5) or intravenously at high doses (n=10). The intensity of depressive symptoms was assessed during a clinical interview carried out before the start of cytokine therapy and five days later using the Montgomery and Asberg Depression Rating Scale (MADRS). On the same days, blood samples were collected for each patient to measure serum concentrations of cytokines (IL-6, IL-10, IL-1ra) and cytokine-receptors (sIL-2R, LIF-R). Results showed that patients treated with IL-2 or IL-2+IFN-alpha displayed concomitant mood symptoms and increased serum cytokine levels during treatment. In these patients, the intensity of depressive symptoms at endpoint was positively correlated with the increases measured in serum levels of IL-10 between baseline and endpoint. IL-10 is an anti-inflammatory cytokine that is produced in response to the production of pro-inflammatory cytokines, and thereby reflects an inflammatory response. These results support the hypothesis of close relationship between depressive symptoms and the activation of the cytokine network.

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Authors: Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., & Neveu, P. J.
Affiliations: Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Maastricht University Medical Centre (NL)
Corresponding author: Capuron, Lucile
ORCID: Capuron, Lucile
Ravaud, Alain
Dantzer, Robert
Maes, Michael
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2001-11
Volume: 26
Issue: 8
Pages: 797-808
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/s0306-4530(01)00030-0
OpenAlex: W2047987784
Cited by: 201
References: 35
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 12 · 2017: 6 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 7 · 2012: 5
FWCI: 3.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: immune activation, depressive symptoms, cancer patients, interleukin-2, interferon-alpha, cytokine therapy, IL-10, serum cytokines, soluble interleukin-2 receptor, inflammation, mood disorders
MeSH terms: Affect, Aged, Carcinoma, Renal Cell, Depression, Female, Humans, Immunity, Interleukin-2, Kidney Neoplasms, Male, Middle Aged, Cytokines, Interferon-alpha

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Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy

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