Muscarinic presynaptic inhibition of neostriatal glutamatergic afferents is mediated by Q-type Ca2+ channels
Abstract
Cholinergic presynaptic inhibition was investigated on neostriatal glutamatergic transmission. Paired pulse facilitation (PPF) of orthodromic population spikes (PS) were used to construct a concentration-response relationship for muscarine on presynaptic inhibition. Muscarine had an effect proportional to its extracellular concentration with an EC50 (mean +/- standard estimation error) of: 2.5 +/- 1.5 nM, and a maximal effect (saturation) of 245 +/- 16%. Several peptidic toxins against some voltage-gated Ca2+-channels increased PPF indicating that the Ca2+-channels they block participate in transmitter release. However, neither 1 microM omega-conotoxin GVIA, a specific blocker of N-type Ca2+-channels, nor 10-30 nM omega-agatoxinTK, a selective blocker of P-type Ca2+-channels, were able to occlude muscarine's effect on presynaptic inhibition. Nevertheless, 100-400 nM omega-agatoxinTK occluded muscarine's action on PPF in a dose-dependent manner. These results are consistent with Q-type Ca2+-channels mediating muscarinic presynaptic inhibition of neostriatal afferents.
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Muscarinic acetylcholine receptors reduce the probability of glutamate release from excitatory afferents to the striatum, negatively regulating the ability of these inputs to drive striatal activity.
“In contrast, mAChRs reduce the probability of glutamate release from excitatory afferents to the striatum, negatively regulating the ability of these inputs to drive striatal activity (Barral et al., 1999; Higley et al., 2009; Pakhotin and Bracci, 2007).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Barral et al., 1999
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
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- Authors
- Barral, J., Galarraga, E., & Bargas, J.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Corresponding author
- Barral, J
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 49
- Issue
- 4
- Pages
- 285-289
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2053168522
- Cited by
- 52
- References
- 25
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 4 · 2012: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- neostriatum, glutamatergic afferents, Q-type calcium channels, paired-pulse facilitation, muscarine, omega-conotoxin GVIA, N-type calcium channels, P-type calcium channels, cholinergic modulation, neurotransmitter release
- MeSH terms
- Afferent Pathways, Animals, Calcium Channel Blockers, Dose-Response Relationship, Drug, Evoked Potentials, Muscarine, Neural Inhibition, Peptides, Spider Venoms, Calcium Channels, Neostriatum, Rats, Wistar, Receptors, Presynaptic, Presynaptic Terminals, Glutamic Acid, Muscarinic Agonists, omega-Conotoxin GVIA, omega-Agatoxin IVA, Rats
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