Cited by 150Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on Behavior

Muscarinic modulation of striatal function and circuitry

Goldberg, Joshua A., Ding, Jun B., Surmeier, D. James·2012·Handbook of Experimental Pharmacology

Abstract

Striatal cholinergic interneurons are pivotal modulators of the striatal circuitry involved in action selection and decision making. Although nicotinic receptors are important transducers of acetylcholine release in the striatum, muscarinic receptors are more pervasive and have been more thoroughly studied. In this review, the effects of muscarinic receptor signaling on the principal cell types in the striatum and its canonical circuits will be discussed, highlighting new insights into their role in synaptic integration and plasticity. These studies, and those that have identified new circuit elements driven by activation of nicotinic receptors, make it clear that temporally patterned activity in cholinergic interneurons must play an important role in determining the effects on striatal circuitry. These effects could be critical to the response to salient environmental stimuli that serve to direct behavior.

Integrity signals

Registry

Crossref · 10.1007/978-3-642-23274-9_10

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160 of 160 references verified0 citation errors · 0 not checkable

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  • Cholinergic interneurons and their regulation of muscarinic receptor signaling are critical components in striatum-dependent decision making.

    “Additionally, it is clear that cholinergic interneurons and their regulation of muscarinic receptor signaling are also critical components in striatum-dependent decision making (see, e.g. (Goldberg et al., 2012)).”

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Authors
Goldberg, J. A., Ding, J. B., & Surmeier, D. J.
Affiliations
  • Northwestern University (US)
  • Harvard University (US)
Corresponding author
Surmeier, D. James
Venue
Handbook of Experimental Pharmacology
Published
2011-11-03
Issue
208
Pages
223-241
ISSN
  • 0171-2004 (ISSN-L)
  • 1865-0325
OpenAlex
W2171464354
Cited by
150
References
160
Citations by year
2026: 7 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 15 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 1
FWCI
6.88
Type
book chapter
Language
en
Open access
closed
Locations
  • Handbook of experimental pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
muscarinic receptors, striatum, cholinergic interneurons, striatal circuitry, nicotinic acetylcholine receptors, synaptic integration, synaptic plasticity, action selection, decision-making, acetylcholine, salient stimuli
MeSH terms
Acetylcholine, Animals, Basal Ganglia, Dystonia, Humans, Interneurons, Neural Pathways, Parkinson Disease, Receptors, Muscarinic, Signal Transduction, Muscarinic Antagonists

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