Cited by 26Substance Abuse Treatment and OutcomesOpioid Use Disorder TreatmentPharmaceutical Practices and Patient Outcomes

Long-Term Outcome after Benzodiazepine Withdrawal Treatment in Subjects with Complicated Dependence

Vorma, Helena, Naukkarinen, Hannu, Sarna, Seppo, Kuoppasalmi, Kimmo·2003·Drug and Alcohol Dependence

Abstract

Background The study aimed to monitor subjects with benzodiazepine (BZ) dependence after withdrawal treatment in order to evaluate long-term outcome and predictors of remaining BZ-free. Subjects with high-dose dependence or co-occurring alcohol problems were not excluded.Method Seventy-six participants in an earlier, randomized, controlled trial of outpatient BZ discontinuation were interviewed, and documents from their treatment settings obtained, along with urine and serum samples for BZ use. Long-term outcomes for a cognitive-behavioral treatment group and a treatment-as-usual group were measured.Results BZ discontinuation treatment outcomes were maintained in both treatment groups. No between-group differences were found. At the end of the study 25% of the subjects were BZ-free, and the median dose decrease from pre-treatment levels was 16.1 mg in diazepam equivalents. Subjects with pre-treatment doses exceeding 40 mg were able to maintain their doses at therapeutic levels through the follow-up. Pre-treatment low BZ dose, no previous withdrawal attempts, and high life satisfaction predicted success in staying BZ-free.Conclusions In subjects with complicated BZ dependence, the benefits of BZ discontinuation treatment may persist, but more studies are needed.

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Crossref · 10.1016/s0376-8716(03)00014-0

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Authors
Vorma, H., Naukkarinen, H., Sarna, S., & Kuoppasalmi, K.
Affiliations
  • A-Clinic Foundation (FI)
  • Helsinki University Hospital (FI)
  • University of Helsinki (FI)
Corresponding author
Vorma, Helena
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2003-06
Volume
70
Issue
3
Pages
309-314
ISSN
0376-8716 (ISSN-L)
OpenAlex
W2055869235
Cited by
26
References
29
Citations by year
2026: 1 · 2024: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
1.21
Type
journal article
Language
en
Open access
closed
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Yrjö Jahnssonin Säätiö
  • Alkoholitutkimussäätiö
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
benzodiazepine dependence, long-term outcomes, cognitive behavioral therapy, usual care, predictors of treatment success, life satisfaction, alcohol problems
MeSH terms
Adult, Benzodiazepines, Female, Follow-Up Studies, Forecasting, Humans, Male, Anti-Anxiety Agents, Cognitive Behavioral Therapy, Odds Ratio, Treatment Outcome, Substance-Related Disorders

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