Factors Predicting Long-Term Outcome after Chronic Benzodiazepine Therapy

Holton, Anthony; Riley, Patrick; Tyrer, Peter

doi:10.1016/0165-0327(92)90109-j

Cited by 33Substance Abuse Treatment and OutcomesPharmaceutical Practices and Patient OutcomesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Factors Predicting Long-Term Outcome after Chronic Benzodiazepine Therapy

Holton, Anthony, Riley, Patrick, Tyrer, Peter·1992·Journal of Affective Disorders

DOI 10.1016/0165-0327(92)90109-j

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Abstract

41 patients who took part in a withdrawal programme from long-term treatment with diazepam in a controlled clinical trial were followed up five years later. Assessments were made of outcome derived from clinical symptomatology, formal psychiatric diagnosis, psychotropic drug use and frequency of contact with both primary care and psychiatric services. Using discriminant function analysis it was found that better outcome was associated with younger patients, fewer symptoms at time of withdrawal and, more particularly, six months later, less personality disturbance, and longer duration of diazepam use before withdrawal. The implications are discussed with particular reference to policies for withdrawing benzodiazepines.

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Psychopathological variables, such as psychological suffering, anxiety or insomnia, best predict relapse rates in benzodiazepine withdrawal programs.
“but it is the psychopathological variables [86,87,88,89,90,91] (e.g., psychological suffering, anxiety or insomnia) which best predict relapse rates in withdrawal programs.”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [90]
Insomnia is a notable symptom of withdrawal syndromes and a factor of relapse.
“Insomnia is a notable symptom of withdrawal syndromes and a factor of relapse as emphasized by many studies [38,88,90].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [90]

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Authors: Holton, A., Riley, P., & Tyrer, P.
Affiliations: Epsom Hospital (GB)
University of Nottingham (GB)
St Charles Hospital (GB)
Corresponding author: Tyrer, Peter
ORCID: Tyrer, Peter
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 1992-04
Volume: 24
Issue: 4
Pages: 245-252
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/0165-0327(92)90109-j
OpenAlex: W2160403301
Cited by: 33
References: 29
Citations by year: 2023: 2 · 2021: 3 · 2020: 2
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: benzodiazepine withdrawal, diazepam, long-term outcomes, prognostic factors, personality disorders, age, psychiatric diagnosis, psychotropic drug use, primary care contacts
MeSH terms: Adult, Age Factors, Mental Disorders, Benzodiazepines, Diazepam, Employment, Female, Follow-Up Studies, Humans, Male, Personality Disorders, Personality Inventory, Probability, Prognosis, Sex Factors, Substance Withdrawal Syndrome, Substance-Related Disorders

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Factors Predicting Long-Term Outcome after Chronic Benzodiazepine Therapy

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