Regulation of mRNA stability in mammalian cells
Abstract
The regulation of mRNA decay is a major control point in gene expression. The stability of a particular mRNA is controlled by specific interactions between its structural elements and RNA-binding proteins that can be general or mRNA-specific. Regulated mRNA stability is achieved through fluctuations in half-lives in response to developmental or environmental stimuli like nutrient levels, cytokines, hormones and temperature shifts as well as environmental stresses like hypoxia, hypocalcemia, viral infection, and tissue injury. Furthermore, in specific disorders like some forms of neoplasia, thalassemia and Alzheimer's disease, deregulated mRNA stability can lead to the aberrant accumulation of mRNAs and the proteins they encode. This review presents a discussion of some recently identified examples of regulated and deregulated mRNA stability in order to illustrate the diversity of genes regulated by alterations in the degradation rates of their mRNAs.
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mRNA stability and translation are controlled by a complex network of RNA/protein interactions and depend on the primary and secondary structures of mRNAs, their rates of translation, and the initiation of one of the various degradation mechanisms.
“mRNA stability and translation are controlled by a complex network of RNA/protein interactions and depend on the primary and secondary structures of mRNAs, their rates of translation, and the initiation of one of the various degradation mechanisms.[28][29][30][31]”
From Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells (2006) · cites this paper as [28]
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AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948 · see citing works
Nagy, E., & Rigby, W. F. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2755 · Cited by 361 · see citing works
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Tools for translation: non-viral materials for therapeutic mRNA delivery
Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799 · see citing works
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625 · see citing works
Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517 · see citing works
Orlandini von Niessen, A. G., Poleganov, M. A., Rechner, C., Plaschke, A., Kranz, L. M., Fesser, S., Diken, M., Löwer, M., Vallazza, B., Beissert, T., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.12.011 · Cited by 365 · see citing works
Novel approaches for vaccine development
Gebre, M. S., Brito, L. A., Tostanoski, L. H., Edwards, D. K., Carfi, A., & Barouch, D. H. (2021) · Cell · doi:10.1016/j.cell.2021.02.030 · Cited by 347 · see citing works
p38MAPK plays a crucial role in stromal-mediated tumorigenesis
Alspach, E., Flanagan, K. C., Luo, X., Ruhland, M. K., Huang, H., Pazolli, E., Donlin, M. J., Marsh, T., Piwnica-Worms, D., Monahan, J., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0743 · Cited by 167 · see citing works
Modulation of mRNA stability as a novel therapeutic approach
Eberhardt, W., Doller, A., Akool, E.-S., & Pfeilschifter, J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.002 · Cited by 173 · see citing works
Defining a neuron: neuronal ELAV proteins
Pascale, A., Amadio, M., & Quattrone, A. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7017-y · Cited by 158 · see citing works
Protein synthesis in sperm: Dialog between mitochondria and cytoplasm
Gur, Y., & Breitbart, H. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.11.015 · Cited by 142 · see citing works
Bronicki, L. M., & Jasmin, B. J. (2013) · RNA · doi:10.1261/rna.039164.113 · Cited by 126 · see citing works
Kunchithapautham, K., & Rohrer, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.214593 · Cited by 71 · see citing works
Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma
Tang, X., Zhang, S., Fu, R., Zhang, L., Huang, K., Peng, H., Dai, L., & Chen, Q. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01208 · Cited by 69 · see citing works
Mandal, P., Novotny, M., & Hamilton, T. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.6085 · Cited by 45 · see citing works
Deschênes-Furry, J., Mousavi, K., Bolognani, F., Neve, R. L., Parks, R. J., Perrone-Bizzozero, N. I., & Jasmin, B. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4626-06.2007 · Cited by 43 · see citing works
Lee, Y.-S., Choi, S.-L., Jun, H., Yim, S.-J., Lee, J.-A., Kim, H. F., Lee, S.-H., Shim, J., Lee, K., Jang, D.-J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116224109 · Cited by 15 · see citing works
- Authors
- Guhaniyogi, J., & Brewer, G.
- Corresponding author
- Brewer, Gary
- ORCID
- Brewer, Gary
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 265
- Issue
- 1-2
- Pages
- 11-23
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2076510291
- Cited by
- 729
- References
- 2
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 7 · 2023: 4 · 2022: 11 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 16 · 2017: 13 · 2016: 28 · 2015: 28 · 2014: 33 · 2013: 38 · 2012: 39
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Cancer Institute (CA52443, R01CA052443)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA stability, mRNA degradation, RNA-binding proteins, gene expression regulation, mRNA half-life, environmental stress, hypoxia, viral infection, thalassemia, Alzheimer's disease, cancer, developmental regulation
- MeSH terms
- Animals, Gene Expression Regulation, Humans, RNA, Messenger, RNA Stability
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