Cited by 291Adrenal Hormones and DisordersAnalytical Chemistry and ChromatographyMetabolomics and Mass Spectrometry Studies

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Profiling steroid hormones and urinary steroids

Shackleton, C.H.L.·1986·Journal of Chromatography B Biomedical Sciences and Applications

DOI 10.1016/s0378-4347(00)80683-0

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Abstract

This paper reviews techniques utilized in the profiling of steroids in body fluids and tissues. Methods for profiling plasma unconjugated steroids and urinary steroid metabolites are focused on. Concentrations or levels of excretion of a variety of steroids have been documented and reviewed. The importance of profiling techniques in the study of normal and pathophysiology of hormonal steroids is discussed.

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Lipid extraction of tissues with a low-toxicity solvent
Hara, A., & Radin, N. S. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90046-5 · Cited by 2,568
A Syndrome of Apparent Mineralocorticoid Excess Associated with Defects in the Peripheral Metabolism of Cortisol*
Ulick, S., Kodama, T., GUNCZIER, P., Zanconato, G., Ramirez, L. C., Rauh, W., Rösler, A., Bradlow, H. L., & New, M. I. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-5-757 · Cited by 494
Hydrolysis of Ketosteroid Hydrogen Sulfates by Solvolysis Procedures
Burstein, S., & Lieberman, S. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64759-3 · Cited by 421
Extraction of steroid conjugates with a neutral resin
Bradlow, H. L. (1968) · Steroids · doi:10.1016/s0039-128x(68)80139-4 · Cited by 379
Use of a Mass Spectrometer as a Detector and Analyzer for Effluent Emerging from High Temperature Gas Liquid Chromatography Columns.
Ryhage, R. (1964) · Analytical Chemistry · doi:10.1021/ac60210a019 · Cited by 329
Clinical and Biochemical Variability of Congenital Adrenal Hyperplasia Due to llβ-Hydroxylase Deficiency, A Study of 25 Patients*
ZACHMANN, M., TASSINARI, D., & PRADER, A. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-2-222 · Cited by 293
Use of sep-pak ® cartridges for urinary steroid extraction: evaluation of the method for use prior to gas chromatographic analysis
Shackleton, C. H. L., & Whitney, J. O. (1980) · Clinica Chimica Acta · doi:10.1016/0009-8981(80)90451-9 · Cited by 252
Diagnosis and Nomenclature of the Disorders of the Terminal Portion of the Aldosterone Biosynthetic Pathway
Ulick, S. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-1-92 · Cited by 218
Pattern of Plasma Dehydroepiandrosterone Sulfate Levels in Humans from Birth to Adulthood: Evidence for Testicular Production*
PERETTI, E. D., & Forest, M. G. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-3-572 · Cited by 213
Simultaneous radioimmunoassay of plasma aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone
Sippell, W. G., BIDLINGMAIER, F., Becker, H., Brünig, T., Dörr, H. G., Hahn, H. J., Golder, W. A., Hollmann, G., & Knorr, D. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)90104-8 · Cited by 187

Show all 204 references

Research works printed but not linked: 26

Vestergaard, 1978, Acta Endocrinol., 217, 96
Siiteri, 1973, Methods Enzymol., 42, 485
Schöneshöfer, 1983, J. Clin. Chem. Clin. Biochem., 21, 231
Axelson, 1983, J. Steroid Biochem., 18, 313, 10.1016/0022-4731(83)90109-7 · DOI
Sjövall, 1970, Ann. Clin. Res., 2, 393
Sjövall, 1968, Acta Endocrinol., 57, 247, 10.1530/acta.0.0570247 · DOI
Vestergaard, 1978, Acta Endocrinol., 217, 76
Vestergaard, 1978, Acta Endocrinol., 217, 157
Kornel, 1973, Res. Steroids, 5, 413
Schöneshöfer, 1983, Clin. Chem., 29, 1367, 10.1093/clinchem/29.7.1367 · DOI
Setchell, 1976, J. Steroid Biochem., 7, 615, 10.1016/0022-4731(76)90086-8 · DOI
Lisboa, 1979, Acta Med. Port., 1, 433
S. Akgun, N.H. Ertel, J. Imperato-McGinley, B.S. Sayli and C. Shackleton, Am. J. Med., in press.
Taylor, 1984, J. Endocrinol.
Ulick, 1984, Ped. Adoles. Endocrinol., 13, 145
Forest, 1980, J. Clin. Endocrinol. Metab., 51, 816, 10.1210/jcem-51-4-816 · DOI
Pang, 1980, J. Clin. Endocrinol. Metab., 51, 223, 10.1210/jcem-51-2-223 · DOI
Jänne, 1970, J. Steroid Biochem., 1, 270
Siegel, 1969, Ann. Med. Esp. Fenn., 47, 47
Peltonen, 1979, J. Steroid Biochem., 10, 499, 10.1016/0022-4731(79)90210-3 · DOI
Ruokonen, 1983, J. Androl., 4, 104, 10.1002/j.1939-4640.1983.tb00729.x · DOI
Hammond, 1978, Int. J. Androl., Suppl., 2, 391, 10.1111/j.1365-2605.1978.tb00031.x · DOI
Leinonen, 1980, J. Clin. Endocrinol. Metab., 51, 423, 10.1210/jcem-51-3-423 · DOI
Huhtaniemi, 1977, J. Steroid Biochem., 8, 491, 10.1016/0022-4731(77)90251-5 · DOI
Reynolds, 1976, Perinatal Endocrinol., 8, 23
De Peretti, 1982, Hor. Res., 16, 10, 10.1159/000179480 · DOI

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The analysis of estrone and 17β-estradiol by stir bar sorptive extraction–thermal desorption–gas chromatography/mass spectrometry: Application to urine samples after oral administration of conjugated equine estrogens
Stopforth, A., Burger, B. V., Crouch, A. M., & Sandra, P. J. F. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.05.025 · Cited by 53
Inhibition of 11β-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis
Ackermann, D., Vogt, B., Escher, G., Dick, B., Reichen, J., Frey, B. M., & Frey, F. J. (1999) · Hepatology · doi:10.1002/hep.510300303 · Cited by 51
Determination of the steroid profile in alternative matrices by liquid chromatography tandem mass spectrometry
Gomez-Gomez, A., Miranda, J., Feixas, G., Arranz Betegon, A., Crispi, F., Gratacós, E., & Pozo, O. J. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105520 · Cited by 50
Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from the urinary steroid metabolome
Dhayat, N. A., Dick, B., Frey, B. M., d’Uscio, C. H., Vogt, B., & Flück, C. E. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.009 · Cited by 50
Methods for urinary testosterone analysis
Venturelli, E., Cavalleri, A., & Secreto, G. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00062-n · Cited by 49
Thermospray HPLC/MS: A new mass spectrometric technique for the profiling of steroids
Liberato, D. J., Yergey, A. L., Esteban, N. V., Gómez-Sánchez, C. E., & Shackleton, C. H. L. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90295-0 · Cited by 49
Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT)
Woods, C. P., Corrigan, M., Gathercole, L., TAYLOR, A. E. R., Hughes, B. A., Gaoatswe, G., Manolopoulos, K. N., Hogan, A. E., O’Connell, J., Stewart, P. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4120 · Cited by 49
A comparison of nebulized budesonide with oral prednisolone in the treatment of exacerbations of obstructive pulmonary disease
Morice, A. H., Morris, D., & Lawson-Matthew, P. J. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90216-7 · Cited by 48
Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile
Palermo, A., Botrè, F., de la Torre, X., & Zamboni, N. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.01.055 · Cited by 47
Quantification of testosterone and epitestosterone in human urine samples by stir bar sorptive extraction – thermal desorption – gas chromatography/mass spectrometry: Application to HIV‐positive urine samples
Stopforth, A., Grobbelaar, C. J., Crouch, A. M., & Sandra, P. J. F. (2007) · Journal of Separation Science · doi:10.1002/jssc.200600280 · Cited by 47
Separation and detection of neuroactive steroids from biological matrices
Appelblad, P., & Irgum, K. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(02)00227-3 · Cited by 47
Analysis of urinary estrogens, their oxidized metabolites, and other endogenous steroids by benchtop orbitrap LCMS versus traditional quadrupole GCMS
Franke, A. A., Custer, L. J., Morimoto, Y., Nordt, F. J., & Maskarinec, G. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5164-3 · Cited by 45
General Methods for the Extraction, Purification, and Measurement of Steroids by Chromatography and Mass Spectrometry
Makin, H. L. J., Honour, J. W., Shackleton, C. H. L., & Griffiths, W. J. (2010) · Springer eBooks · doi:10.1023/b135931_3 · Cited by 45
Extra‐adrenal effects of metyrapone include inhibition of the 11‐oxoreductase activity of 11β‐hydroxysteroid dehydrogenase: a model for 11‐HSD I deficiency
Raven, P., Checkley, S. A., & Taylor, N. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb02930.x · Cited by 45
Monitoring testicular activity of male Eurasian (Lynx lynx) and Iberian (Lynx pardinus) lynx by fecal testosterone metabolite measurement
Jewgenow, K., Naidenko, S. V., Göritz, F., Vargas, A., & Dehnhard, M. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.05.015 · Cited by 43
A Novel Nonhepatic Hydroxycholesterol 7α-Hydroxylase That Is Markedly Stimulated by Interleukin-1β
Payne, D. W., Shackleton, C. H. L., Toms, H. C., Ben‐Shlomo, I., Kol, S., deMoura, M. D., Strauss, J. F., & Adashi, E. Y. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18888 · Cited by 43
Routine method for the simultaneous quantification of 17α-hydroxyprogesterone, testosterone, dehydroepiandrosterone, androstenedione, cortisol, and pregnenolone in human serum of neonates using gas chromatography–mass spectrometry
Magnisali, P., Dracopoulou, M., Mataragas, M., Dacou-Voutetakis, A., & Moutsatsou, P. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.07.057 · Cited by 42
Parent and conjugated estrogens and progestagens in surface water of the Santa Ana River: Determination, occurrence, and risk assessment
Ma, L. M., Yates, S. R., & Ashworth, D. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3447 · Cited by 41
Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry
Yamashita, K., Nakagawa, R., Okuyama, M., Honma, S., Takahashi, M., & Numazawa, M. (2008) · Steroids · doi:10.1016/j.steroids.2008.02.009 · Cited by 41
Direct determination of the ratio of tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone in urine by LC–MS–MS
Raffaelli, A., Saba, A., Vignali, E., Marcocci, C., & Salvadori, P. A. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.11.011 · Cited by 41
Metabolites of estradiol in serum, bile, intestine and feces of the domestic cat ()
Shille, V. M., Haggerty, M. A., Shackleton, C. H. L., & Lasley, B. L. (1990) · Theriogenology · doi:10.1016/0093-691x(90)90032-o · Cited by 41
Apparent Cortisone Reductase Deficiency: A Rare Cause of Hyperandrogenemia and Hypercortisolism
Biason‐Lauber, A., Suter, S. L., Shackleton, C. H. L., & ZACHMANN, M. (2000) · Hormone Research in Paediatrics · doi:10.1159/000023577 · Cited by 41
Urinary Steroid Profiling
Taylor, N. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-616-0_17 · Cited by 40
Convenient chromatographic prepurification step before measurement of urinary cortisol by radioimmunoassay
Morineau, G., Gosling, J. P., Patricot, M. C., Soliman, H. R., Boudou, P., Al-Halnak, A., Brun, G. L., Brérault, J.-L., Julien, R., Villette, J., et al. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.5.786 · Cited by 40
Bringing GC–MS profiling of steroids into clinical applications
Choi, M. H., & Chung, B. C. (2014) · Mass Spectrometry Reviews · doi:10.1002/mas.21436 · Cited by 40
Combined 17α-Hydroxylase/17,20-Lyase Deficiency Caused by Phe93Cys Mutation in the CYP17 Gene
Cerbo, A. D., Biason‐Lauber, A., Savino, M., Piemontese, M. R., Giorgio, A. D., Perona, M., & Savoia, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8271 · Cited by 39
Facile synthesis of [16,16,17-2H3]-testosterone, -epitestosterone and their glucuronides and sulfates
Sanaullah, & Bowers, L. D. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00025-8 · Cited by 37
Hydrolysis of conjugated steroids by the combined use of β-glucuronidase preparations from helix pomatia and ampullaria: determination of urinary cortisol and its metabolites
Shibasaki, H., Tanabe, C., Furuta, T., & Kasuya, Y. (2001) · Steroids · doi:10.1016/s0039-128x(01)00118-0 · Cited by 37
Steroid Profiling
Honour, J. W. (1997) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329703400106 · Cited by 37
Identification of phytoestrogens in the urine of male dogs
Juniewicz, P. E., Morell, S. P., Moser, A. B., & EWING, L. L. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90343-3 · Cited by 37
Characterisation and validation of an enzyme-immunoassay for the non-invasive assessment of faecal glucocorticoid metabolites in cheetahs (Acinonyx jubatus)
Ludwig, C., Wachter, B., Silinski-Mehr, S., Ganswindt, A., Bertschinger, H. J., Hofer, H., & Dehnhard, M. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.10.005 · Cited by 36

Authors: Shackleton, C. H. L.
Corresponding author: Shackleton, C.H.L.
Venue: Journal of Chromatography B Biomedical Sciences and Applications
Publisher: Elsevier BV
Published: 1986-06
Volume: 379
Pages: 91-156
ISSN: 0378-4347 (ISSN-L)
DOI: 10.1016/s0378-4347(00)80683-0
OpenAlex: W2001707407
Cited by: 291
References: 204
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 12 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 14 · 2012: 11
FWCI: 3.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Chromatography B Biomedical Sciences and Applications (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am034400-02)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords: steroid hormones, urinary steroid metabolites, steroid profiling, steroid excretion
MeSH terms: Animals, Bile, Body Fluids, Chromatography, Gas, Chromatography, High Pressure Liquid, Chromatography, Liquid, Chromatography, Paper, Chromatography, Thin Layer, Estrogens, Feces, Hormones, Humans, Hydrolysis, Gas Chromatography-Mass Spectrometry, Steroids

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Profiling steroid hormones and urinary steroids

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