Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill
Abstract
Extracts obtained from the leaves of Lavandula angustifolia Mill. (Lamiaceae) are used in Iranian folk medicine as remedies for the treatment of various inflammatory diseases. For evaluation of its probable analgesic and anti-inflammatory effects, hydroalcoholic extract, polyphenolic fraction and essential oil of the leaves of the herb were prepared and their analgesic effects were studied in mice using formalin and acetic acid-induced writhing tests. Carrageenan test in rats was used for assessment of anti-inflammatory activity of above-mentioned fractions. Results showed that while the hydroalcoholic extract (400-1600 mg/kg, p.o.) inhibited only the second phase of formalin test, the polyphenolic fraction (800 and 1600 mg/kg, p.o.) and essential oil (100 and 200 mg/kg, p.o.) suppressed both phases. In acetic acid-induced writhing test, polyphenolic fraction (400 and 800 mg/kg, p.o.) and essential oil (100 and 200 mg/kg, p.o.) reduced the number of abdominal constrictions. Essential oil at a dose of 200mg/kg also inhibited carrageenan-induced paw edema. Results of the present study confirm the traditional use of Lavandula angustifolia for the treatment of painful and inflammatory conditions and calls for further investigations to determine the active chemical constituent(s).
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Carrageenan-induced mouse paw oedema is frequently used to determine anti-inflammatory activity of plant extracts and essential oils.
“Carrageenan-induced mouse paw oedema is frequently used to determine the anti-inflammatory activity of diverse bioactive compounds such as plant extracts and essential oils [87,88,89,90,91,92,93,94,95].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [95]
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- Authors
- Hajhashemi, V., Ghannadi, A., & Sharif, B.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Hajhashemi, Valiollah
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 89
- Issue
- 1
- Pages
- 67-71
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2061245441
- Cited by
- 395
- References
- 23
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 18 · 2023: 28 · 2022: 29 · 2021: 24 · 2020: 32 · 2019: 23 · 2018: 14 · 2017: 20 · 2016: 22 · 2015: 29 · 2014: 25 · 2013: 24 · 2012: 22
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Isfahan University of Medical Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Lavandula angustifolia, essential oils, anti-inflammatory activity, analgesic activity, formalin test, acetic acid-induced writhing, carrageenan-induced paw edema, traditional medicine, inflammatory diseases
- MeSH terms
- Animals, Iran, Male, Gas Chromatography-Mass Spectrometry, Oils, Volatile, Pain Measurement, Plant Extracts, Rats, Wistar, Plant Leaves, Analgesics, Non-Narcotic, Lavandula, Mice, Rats
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