Thyroid autoimmunity and aging
Abstract
Aging is associated with the appearance of several serum autoantibodies, including thyroid autoantibodies. The biological and clinical significance of this phenomenon is still unknown, because, with the exception of primary myxedema, the prevalence of clinically overt thyroid autoimmune diseases is not increased in the elderly. The peculiar link between autoimmune thyroid failure and aging is also underscored by the high prevalence of subclinical hypothyroidism in elderly subjects with positive serum thyroid autoantibodies, and could be the consequence of preferential age-dependent expression of destructive effector mechanisms and/or increased target gland susceptibility. Thyroid autoimmunity and subclinical hypothyroidism have been also implicated in the pathogenesis of other age-associated disorders, in particular coronary heart disease. Interestingly, recent data from our laboratories showed that thyroid autoantibodies are rare in healthy centenarians and in other highly selected aged populations, while they are frequently observed in unselected or hospitalized elderly. Taken together, these data suggest that thyroid autoimmune phenomena are not the consequence of the aging process itself, but rather might be related to age-associated disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Autoimmune hypothyroidism is the most common cause of hypothyroidism at all ages, and the prevalence of thyroid autoimmunity increases with aging.
“Autoimmune hypothyroidism is the most common cause of hypothyroidism at all ages and the prevalence of thyroid autoimmunity increases with aging (23, 26, 27).”
From Levothyroxine therapy in elderly patients with hypothyroidism (2021) · cites this paper as [26]
Cites
The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey
Vanderpump, M. P. J., Tunbrldge, W. M. G., French, J. M., Appleton, D., Bates, D., Clark, F., Evans, J. G., Hasan, D. M., Rodgers, H., Tunbridge, F., et al. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01894.x · Cited by 2,432 · see citing works
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 531 · see citing works
Self-citationAssociation of serum antibodies to heat-shock protein 65 with carotid atherosclerosis
Xu, Q., Wick, G., Willeit, J., Marosi, M., Kiechl, S. J., Luef, G. J., Kleindienst, R., Stulnig, T. M., Wick, G., & Oberhollenzer, F. (1993) · The Lancet · doi:10.1016/0140-6736(93)92613-x · Cited by 513 · see citing works
MARIOTTI, S., FRANCESCHI, C., COSSARIZZA, A., & PINCHERA, N. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-6-686 · Cited by 449 · see citing works
Self-citationIs atherosclerosis an immunologically mediated disease?
Wick, G., Schett, G. A., Amberger, A., Kleindienst, R., & Xu, Q. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80067-0 · Cited by 398 · see citing works
Alzheimer's disease: Genetic aspects and associated clinical disorders
Heyman, A., William Ebomoyi, E., Hurwitz, B. J., Schmechel, D. E., Sigmon, A. H., Weinberg, T., Helms, M. J., & Swift, M. (1983) · Annals of Neurology · doi:10.1002/ana.410140503 · Cited by 272 · see citing works
Palinski, W., Tangirala, R. K., Miller, E. R., Young, S. G., & Witztum, J. L. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1569 · Cited by 239 · see citing works
Thyroid and other organ-specific autoantibodies in healthy ceritenarians
Mariotti, S., Barbesino, G., Caturegli, P., Giacomelli, T., Pinchera, A., Monti, D., Cossarizza, A., Franceschi, C., Sansoni, P., Passeri, G., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)91265-a · Cited by 227 · see citing works
Self-citationVanderpump, M. P. J., Tunbridge, W. M. G., French, J. M., Appleton, D. R., Bates, D., Clark, F., Evans, J. G., Rodgers, H., Tunbridge, F. K. E., & Young, E. T. (1996) · PubMed · doi:10.1089/thy.1996.6.155 · Cited by 207 · see citing works
Do Tricyclic Antidepressants Work?
Coppen, A. J., & Ghose, K. (1976) · The Lancet · doi:10.1016/s0140-6736(76)99012-7 · Cited by 176 · see citing works
Wick, G., & Grubeck‐Loebenstein, B. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01037.x · Cited by 92 · see citing works
Pietrzik, C. U., Hoffmann, J., Stoeber, K., Chen, C., Bauer, C. R., Otero, D. A. C., Roch, J., & Herzog, V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1770 · Cited by 90 · see citing works
Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians
Candore, G., Lorenzo, G. D., Mansueto, P., Melluso, M., Fradà, G., Vecchi, M. L., Pellitteri, M. E., Drago, A., Salvo, A. D., & Caruso, C. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01845-3 · Cited by 88 · see citing works
Thyroid diseases in the elderly
Chiovato, L., Mariotti, S., & Pinchera, A. (1997) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(97)80272-8 · Cited by 77 · see citing works
Self-citationAGE-RELATED INCREASE IN AUTOANTIBODIES
Moulias, R., Proust, J., Wang, A., Congy, F., Marescot, M. R., Devillechabrolle, A., Hamelin, A. P., & Lesourd, B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92547-9 · Cited by 77 · see citing works
Epidemiology of Dementia in Rochester, Minnesota
Kokmen, E., Beard, C. M., O’Brien, P. C., & Kurland, L. T. (1996) · Mayo Clinic Proceedings · doi:10.4065/71.3.275 · Cited by 73 · see citing works
Neuroautoimmunity: Pathogenic Implications for Alzheimer’s Disease
Singh, V. K. (2009) · Gerontology · doi:10.1159/000213837 · Cited by 57 · see citing works
Association between autoimmune thyroid disease and Familial Alzheimers disease
Ewins, D. L., Rossor, M. N., Butler, J., Rogues, P. K., Mullen, M. J., & McGregor, A. M. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb03502.x · Cited by 51 · see citing works
The association between Alzheimer's disease and thyroid disease in Rochester, Minnesota
YOSHIMASU, F., Kokmen, E., HAY, I. D., Beard, C. M., OFFORD, K. P., & Kurland, L. T. (1991) · Neurology · doi:10.1212/wnl.41.11.1745 · Cited by 49 · see citing works
Tumor necrosis factor α augments amyloid β protein (25–35) induced apoptosis in human cells
Blasko, I., Schmitt, T. L., Steiner, E., Trieb, K., & Grubeck‐Loebenstein, B. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00845-8 · Cited by 47 · see citing works
Thyroid Autoimmunity and Ageing
Pinchera, A., Mariotti, S., Barbesino, G., Bechi, R., Sansoni, P., Fagiolo, U., Cossarizza, A., & Franceschi, C. (2008) · Hormone Research · doi:10.1159/000184239 · Cited by 47 · see citing works
Self-citationEffect of age on the induction of autoantibodies.
Goidl, E. A., Michelis, M. A., Siskind, G. W., & Weksler, M. E. (1981) · PubMed Central · Cited by 41 · see citing works
Jaume, J. C., Costante, G., Nishikawa, T., Phillips, D. I. W., Rapoport, B., & McLachlan, S. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7533777 · Cited by 37 · see citing works
Aizawa, T., Ishihara, M., Hashizume, K., Takasu, N., & Yamada, T. (1989) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1989.tb07279.x · Cited by 33 · see citing works
Schmitt, T. L., Steiner, E., Klinger, P., Sztankay, A., & Grubeck‐Loebenstein, B. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636387 · Cited by 29 · see citing works
Regulated O-glycosylation of the Alzheimer beta-A4 amyloid precursor protein in thyrocytes.
Graebert, K. S., Popp, G. M., Kehle, T., & Herzog, V. (1995) · PubMed · Cited by 29 · see citing works
Szabolcs, I., Bernard, W., & Horster, F. A. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07204.x · Cited by 26 · see citing works
The effect of aging on the induction of experimental autoimmune thyroiditis.
Romball, C. G., & Weigle, W. O. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.5.1490 · Cited by 23 · see citing works
Clinical features of perineuritis
Sorenson, E. J., Sima, A. A. F., Blaivas, M., Sawchuk, K. S. L. J., & Wald, J. J. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199709)20:9 · Cited by 23 · see citing works
Schmitt, T. L., Steiner, E., Klingler, P. J., Lassmann, H., & Grubeck‐Loebenstein, B. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530592 · Cited by 18 · see citing works
Okayasu, I., Hatakeyama, S., & Kong, Y.-C. M. (1989) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(89)90055-x · Cited by 16 · see citing works
Age-related Changes in Specificity of Human Natural Autoantibodies to Thyroglobulin
Bouanani, M., Dietrich, G., Hurez, V. J., Kaveri, S., Rio, M. D., Pau, B., & Kazatchkine, M. D. (1993) · Journal of Autoimmunity · doi:10.1006/jaut.1993.1052 · Cited by 15 · see citing works
Cerebral vascular amyloid deposition in rabbits with induced thyroglobulin immunity
PREMACHANDRA, B. N., Naidu, R. G., Williams, I. K., & Blumenthal, H. T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11385-a · Cited by 4 · see citing works
Flagged first, then by citations
2 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works
Hoogendoorn, E. H., Hermus, A. R., de Vegt, F., Ross, H. A., Verbeek, A. L., Kiemeney, L. A., Swinkels, D. W., Sweep, F. C., & den Heijer, M. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.055194 · Cited by 255 · see citing works
Epidemiology of subtypes of hypothyroidism in Denmark.
Carlé, A., Laurberg, P., Pedersen, I. B., Knudsen, N., Perrild, H., Ovesen, L., Rasmussen, L. B., & Jorgensen, T. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02068 · Cited by 195 · see citing works
Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires
Wang, C., Liu, Y., Xu, L. T., Jackson, K., Roskin, K. M., Pham, T. D., Laserson, J., Marshall, E. L., Seo, K., Lee, J.-Y., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301384 · Cited by 179 · see citing works
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 138 · see citing works
Saravanan, P., & Dayan, C. M. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70189-4 · Cited by 135 · see citing works
Thyroid Hormone Signaling and Homeostasis During Aging
Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works
Peeters, R. P. (2008) · Hormones · doi:10.14310/horm.2002.1111035 · Cited by 98 · see citing works
Autoantibodies in autoimmune polyendocrine syndrome type II
Falorni, A., Laureti, S., & Santeusanio, F. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00010-x · Cited by 96 · see citing works
Aging and Neutrophils: There Is Still Much To Do
Fortin, C. F., McDonald, P. P., Lesur, O., & Fülöp, T. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0750 · Cited by 94 · see citing works
The Role of Nutrition in Immunity in the Aged
Lesourd, B., Mazari, L., & Ferry, M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01628.x · Cited by 90 · see citing works
Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: Significance in the elderly
Davis, J. D., Stern, R. A., & Flashman, L. A. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0073-6 · Cited by 89 · see citing works
Complexity of Anti‐immunosenescence Strategies in Humans
Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L., et al. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00295.x · Cited by 81 · see citing works
Self-citationIs vitamin D related to pathogenesis and treatment of Hashimoto's thyroiditis?
Mazokopakis, E. E., Papadomanolaki, M. G., Tsekouras, K. C., Evangelopoulos, A. D., Kotsiris, D. A., & Tzortzinis, A. (2015) · PubMed · Cited by 82 · see citing works
Approach to and Treatment of Thyroid Disorders in the Elderly
Papaleontiou, M., & Haymart, M. R. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.01.013 · Cited by 82 · see citing works
Immunological memory and late onset autoimmunity
Stacy, S., Krolick, K. A., Infante, A. J., & Kraig, E. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00035-0 · Cited by 78 · see citing works
Thyroid diseases in the elderly
Chiovato, L., Mariotti, S., & Pinchera, A. (1997) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(97)80272-8 · Cited by 77 · see citing works
Self-citationCaruso, C., Candore, G., Romano, G. C., Lio, D., Bonafè, M., Valensin, S., & Franceschi, C. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00255-4 · Cited by 77 · see citing works
Self-citationJeune, B. (2002) · Aging Clinical and Experimental Research · doi:10.1007/bf03324421 · Cited by 76 · see citing works
High prevalence of autoantibodies among Danish centenarians
Andersen‐Ranberg, K., Høier‐Madsen, M., Wiik, A. S., Jeune, B., & Hegedűs, L. D. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02575.x · Cited by 60 · see citing works
Levothyroxine therapy in elderly patients with hypothyroidism
Effraimidis, G., Watt, T., & Feldt-Rasmussen, U. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.641560 · Cited by 60 · see citing works
“Autoimmune hypothyroidism is the most common cause of hypothyroidism at all ages and the prevalence of thyroid autoimmunity increases with aging (23, 26, 27).”
BackgroundLa’ulu, S. L., Slev, P. R., & Roberts, W. L. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.07.018 · Cited by 49 · see citing works
Long-term lithium treatment and thyroid antibodies: a controlled study
Baethge, C., Blumentritt, H., Berghöfer, A., Bschor, T., Glenn, T., Adli, M., Schlattmann, P., Bauer, M., & Finke, R. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0554 · Cited by 48 · see citing works
Kamath, C., Young, S., Kabelis, K., Sanders, J. F., Adlan, M. A., Furmaniak, J., Smith, B. R., & Premawardhana, L. D. K. E. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04397.x · Cited by 46 · see citing works
Thyroid hormones in extreme longevity
Garasto, S., Montesanto, A., Corsonello, A., Lattanzio, F., Fusco, S., Passarino, G., Giarritta, V. P., & Corica, F. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.03.002 · Cited by 41 · see citing works
Baştemir, M., Emral, R., Erdoğan, G., & Güllü, S. (2006) · Thyroid · doi:10.1089/thy.2006.16.1265 · Cited by 37 · see citing works
RetractedGeriatric thyroidology: An update
Ajish, T., & Jayakumar, R. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.98006 · Cited by 33 · see citing works
Immunity, autoimmunity and autoimmune diseases in older people.
Rosato, E., & Salsano, F. (2008) · PubMed · Cited by 33 · see citing works
D’Aurizio, F., Metus, P., Ferrari, A. M., Caruso, B., Castello, R., Villalta, D., Steffan, A., Gaspardo, K., Pesente, F., Bizzaro, N., et al. (2017) · Autoimmunity Highlights · doi:10.1007/s13317-017-0096-3 · Cited by 30 · see citing works
Managing thyroid dysfunction in the elderly
Mohandas, R., & Gupta, K. L. (2003) · Postgraduate Medicine · doi:10.3810/pgm.2003.05.1407 · Cited by 28 · see citing works
Sapin, R., d’Herbomez, M., Gasser, F., Meyer, L., & Schlienger, J.-L. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00114-0 · Cited by 27 · see citing works
Mocchegiani, E., Giacconi, R., Cipriano, C., Muti, E., Gasparini, N., & Malavolta, M. (2004) · Immunity & Ageing · doi:10.1186/1742-4933-1-5 · Cited by 27 · see citing works
Enfermedad tiroidea subclínica en la población anciana sana institucionalizada
Ayala, C., León, M. V. C., Rodríguez-Hernández, J. R., Silva, H., Pereira, J. L. S., & García‐Luna, P. P. (2001) · Medicina Clínica · doi:10.1016/s0025-7753(01)72169-0 · Cited by 25 · see citing works
Autoimmunity in centenarians. A paradox
Anaya, J., Lozada-Martínez, I. D., Torres, I. P., & Shoenfeld, Y. (2024) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2024.100237 · Cited by 23 · see citing works
Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients
Ravaglia, G. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00037-8 · Cited by 23 · see citing works
Giacconi, R., Cipriano, C., Muzzioli, M., Gasparini, N., Orlando, F., & Mocchegiani, E. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00011-3 · Cited by 22 · see citing works
Anti-Transglutaminase Antibodies and Age
Baldas, V., Not, T., Tommasini, A., Ansaldi, F., Demarini, S., Sblattero, D., Marzari, R., Torelli, L., Burlina, A., Tiribelli, C., et al. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.036012 · Cited by 13 · see citing works
Mariotti, S., Barbesino, G., Chiovato, L., Marinò, M., Pinchera, A., Zuliani, G., Mezzetti, A., & Fellin, R. (1999) · Aging Clinical and Experimental Research · doi:10.1007/bf03339813 · Cited by 12 · see citing works
Self-citationThe Role of Nutrition in Immunity of the Aged
Walrand, S., Vasson, M., & Lesourd, B. (2003) · doi:10.1002/9780470774595.ch11 · Cited by 12 · see citing works
Gheri, R. G., Pucci, P., FALSETTI, C., Luisi, M., Cerisano, G., Gheri, C. F., Petruzzi, I., Pinzani, P., Salvadori, B., & Petruzzi, E. (2003) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(03)00080-3 · Cited by 11 · see citing works
Antithyroid Antibodies Are Implicated in Epileptogenesis of Adult Patients With Epilepsy
Tsai, M., Fu, T., Chen, N.-C., Shih, F.-Y., Lu, Y., Cheng, M.-Y., Chuang, H., & Chuang, Y. (2015) · Medicine · doi:10.1097/md.0000000000001059 · Cited by 10 · see citing works
Long-Term Variations of Antithyroperoxidase Antibodies and its Clinical Significance
Keyhanian, M., Sarvghadi, F., Mehran, L., Amouzegar, A., Beigy, M., Tohidi, M., & Azizi, F. (2019) · Hormone and Metabolic Research · doi:10.1055/a-0887-6213 · Cited by 9 · see citing works
Choudhury, A., Mukherjee, P., Basu, S. K., George, A., Rath, S., & Bal, V. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1713 · Cited by 9 · see citing works
Hypothyroidism in Older Adults
Kim, M. I. (2000) · Cited by 8 · see citing works
Autoantibodies to Poly(ADP-Ribose) Polymerase in Centenarians: A Reappraisal of Grabar’s Hypothesis
Lisa, A., Monti, D., Franceschi, C., & Scovassi, A. I. (2009) · Gerontology · doi:10.1159/000213652 · Cited by 7 · see citing works
Self-citationThyroid Disorders in the Elderly
Higgins, K. M. (2018) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2018.01.011 · Cited by 6 · see citing works
Nam, H.-Y., Paeng, J.-C., Chung, J.-K., Kang, K. W., Cheon, G. J., Kim, Y., Park, D. J., Park, Y. J., Min, H. S., & Lee, D. S. (2014) · PubMed · doi:10.3413/nukmed-0604-13-06 · Cited by 5 · see citing works
Lee, F., Gallo, M. V., Schell, L. M., Jennings, J. A., Lawrence, D. A., & Akwesasne Task Force on the Environment (2023) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2023.2226685 · Cited by 5 · see citing works
Thyroid hormones, mitochondria, aging, and cancer
Glinsky, G. V., Hercbergs, A. A., & Davis, P. J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1682089 · Cited by 6 · see citing works
La thyroïde de la personne âgée (Partie 1)
Rétornaz, F., Castinetti, F., Molines, C., & Oliver, C. (2013) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.11.011 · Cited by 4 · see citing works
Thyroid disorders in older people
Verma, A. K., & Hasan, T. (2009) · Reviews in Clinical Gerontology · doi:10.1017/s0959259809990281 · Cited by 3 · see citing works
(2010) · CRC Press eBooks · doi:10.1201/ebk1439813423-c3 · Cited by 2 · see citing works
Causes and laboratory investigation of hypothyroidism
Santini, F., & Pinchera, A. (2011) · doi:10.1093/med/9780199235292.003.3243 · Cited by 1 · see citing works
Self-citationInterpretation of Hormone Levels in Older Patients: Points for Consideration
Sztefko, K., & Szybowska, P. (2012) · International Journal of Endocrinology · doi:10.1155/2012/712425 · Cited by 1 · see citing works
Surgical Disorders of the Thyroid in the Elderly
Wu, L. S., Sosa, J., & Udelsman, R. (2011) · Springer eBooks · doi:10.1007/978-1-4419-6999-6_34
Daubric, M. H. (2001) · Cited by 1 · see citing works
Cooper, D. S. (2006) · Springer eBooks · doi:10.1007/0-387-22621-4_48 · Cited by 1 · see citing works
Επιπολασμός της κοιλιοκάκης σε ομάδες αυξημένου κινδύνου
Νταβέλης, Ι. (2010) · doi:10.12681/eadd/23234
Mariotti, S., & Boi, F. (2004) · Elsevier eBooks · doi:10.1016/b0-12-475570-4/01278-6
Self-citationMariotti, S. (2011) · doi:10.1093/med/9780199235292.003.0138
Self-citationDominguez, L. J., Belvedere, M., & Barbagallo, M. (2012) · Pathy's Principles and Practice of Geriatric Medicine · doi:10.1002/9781119952930.ch98
Surampudi, P. N., Wang, C., Lue, Y., & Swerdloff, R. S. (2014) · CRC Press eBooks · doi:10.1201/b16712-23
Thyroid disorders in elderly people: challenges, pearls and updates
Tawfik, M. (2018) · Egyptian Journal of Geriatrics and Gerontology · doi:10.21608/ejgg.2018.30872
Dominguez, L. J., & Barbagallo, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11338-8
Chun, A. K. (2007) · Springer eBooks · doi:10.1007/978-0-387-32326-8_25
(2003) · Thyroid · doi:10.1089/105072503321087097
Dominguez, L. J., & Barbagallo, M. (2022) · Wiley eBooks · doi:10.1002/9781119484288.ch83
La thyroïde aux différents âges de la vie
Faivre-Defrance, F. (2022) · Elsevier eBooks · doi:10.1016/b978-2-294-77583-3.00024-1
Deng, Z., Davison, K., Cartier, M. S., MacNeil, A., & Fuller‐Thomson, E. (2025) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2025.100129
Vassallo, A., Ferrari, F., di Filippo, L., Perticone, F., Castellino, L., Giustina, A., & Loli, P. (2026) · Endocrine · doi:10.1007/s12020-026-04582-y
- Authors
- Mariotti, S., Chiovato, L., Franceschi, C., & Pinchera, A.
- Affiliations
- University of Cagliari (IT)
- University of Pisa (IT)
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Mariotti, Stefano
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 33
- Issue
- 6
- Pages
- 535-541
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W1974613905
- Cited by
- 73
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- thyroid autoimmunity, aging, thyroid autoantibodies, subclinical hypothyroidism, autoimmune thyroid disease, centenarians, coronary artery disease, age-related diseases, primary myxedema
- MeSH terms
- Aging, Animals, Health Status, Humans, Thyroid Diseases, Thyroid Gland, Autoimmunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
