Thyroid hormones and aging

Peeters, Robin P.

doi:10.14310/horm.2002.1111035

Cited by 99Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

Thyroid hormones and aging

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Peeters, Robin P.·2008·Hormones

DOI 10.14310/horm.2002.1111035

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Abstract

With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly. In general, subclinical thyroid disease is associated with an increased risk of overt thyroid dysfunction and with different negative clinical parameters. In the elderly, however, it is unclear whether these changes represent physiologic changes in thyroid hormone levels with advancing age or whether they represent true (subclinical) thyroid disease. This review describes the changes in thyroid hormone levels with aging and the mechanisms behind these changes, and also discusses whether subclinical thyroid disease should be treated in the elderly.

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Several different variations of thyroid pathophysiology have been described in the elderly, including reduced lean body mass, reduced T4 absorption and outer ring deiodination, comorbidities, and drug use.
“Several different variations of thyroid pathophysiology have been described in the elderly (92, 93). Reduced lean body mass, reduced T4 absorption and outer ring deiodination as well as the presence of comorbidities and the use of drugs are among them (14, 42, 51).”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [93]

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Authors: Peeters, R. P.
Affiliations: Erasmus MC (NL)
Corresponding author: Peeters, Robin P.
ORCID: Peeters, Robin P.
Venue: Hormones
Publisher: Springer Science and Business Media LLC
Published: 2008-01
Volume: 7
Issue: 1
Pages: 28-35
ISSN: 1109-3099 (ISSN-L)
2520-8721
DOI: 10.14310/horm.2002.1111035
OpenAlex: W2111688189
Cited by: 98
References: 82
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 13 · 2012: 6
FWCI: 0.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: HORMONES (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: thyroid hormones, aging, subclinical thyroid dysfunction, older adults, thyroid hormone metabolism, thyroid hormone synthesis
MeSH terms: Aging, Animals, Humans, Thyroid Function Tests, Thyroid Hormones, Thyrotropin

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