The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation
Open accessAbstract
Objectives The purpose of this study was to determine whether atrial expression of the extracellular signal-regulated kinases Erk1/Erk2 and of the angiotensin-converting enzyme (ACE) is altered in patients with atrial fibrillation (AF).Background Recent studies have demonstrated that atrial fibrosis can provide a pathophysiologic substrate for AF. However, the molecular mechanisms responsible for the development of atrial fibrosis are unclear.Methods Atrial tissue samples of 43 patients undergoing open heart surgery were examined. Seventeen patients had chronic persistent AF (> or =6 months; CAF), 8 patients had paroxysmal AF (PAF) and 18 patients had no history of AF. Erk expression was analyzed at the mRNA (quantitative reverse transcription polymerase chain reaction), the protein (immunoblot techniques) and atrial tissue (immunohistochemistry) levels. Erk-activating kinases (MEK1/2) and ACE were analyzed by immunoblot techniques.Results Increased amounts of Erk2-mRNA were found in patients with CAF (75 +/- 20 U vs. sinus rhythm: 31 +/- 25 U; p < 0.05). Activated Erk1/Erk2 and MEK1/2 were increased to more than 150% in patients with AF compared to patients with sinus rhythm. No differences between CAF and PAF were found. The expression of ACE was three-fold increased during CAF. Amounts of activated Erk1/Erk2 were reduced in patients treated with ACE inhibitors. Patients with AF showed an increased expression of Erk1/Erk2 in interstitial cells and marked atrial fibrosis.Conclusions An ACE-dependent increase in the amounts of activated Erk1/Erk2 in atrial interstitial cells may contribute as a molecular mechanism for the development of atrial fibrosis in patients with AF. These findings may have important impact on the treatment of AF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Inhibition of the renin-angiotensin-aldosterone system can prevent structural remodelling and recurrent AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [244]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500
Epidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
Weber, K. T., & Brilla, C. G. (1991) · Circulation · doi:10.1161/01.cir.83.6.1849 · Cited by 2,035
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,400
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046
Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study.
Sanfilippo, A. J., Abascal, V. M., Sheehan, M., Oertel, L. B., Harrigan, P., Hughes, R. A., & Weyman, A. E. (1990) · Circulation · doi:10.1161/01.cir.82.3.792 · Cited by 739 · cited 2×
“In addition, it is well known that persistent AF, as found in our patient population, is accompanied by a significant dilation of the atria (3,22).”
BackgroundStructural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat
Ausma, J., WIJFFELS, M. C. E. F., Thoné, F., Wouters, L., Allessie, M. A., & Borgers, M. J. (1997) · Circulation · doi:10.1161/01.cir.96.9.3157 · Cited by 669
Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C. T. (1999) · Circulation · doi:10.1161/01.cir.100.4.376 · Cited by 656
Research works printed but not linked: 1
- Goette, 1999, Atrial expression of pro- inflammatory cytokines during chronic atrial fibrillation in humans, PACE, 22, A117
Cited by
Sorted by citations
Items 201–300 of 576
Rondano, E., Dell’Era, G., Luca, G. D., Piccinino, C., Bellomo, G., & Marino, P. N. (2010) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32833757b5 · Cited by 34
Myocardial Perfusion in Nonischemic Dilated Cardiomyopathy With and Without Atrial Fibrillation
Range, F. T., Paul, M., Schäfers, K. P., Açıl, T., Kies, P., Hermann, S., Schober, O., BREITHARDT, G. E., Wichter, T., & Schäfers, M. A. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.055665 · Cited by 34
Aldosterone‐receptor antagonism as a potential therapeutic option for atrial fibrillation
Lendeckel, U., Dobrev, D., & Goette, A. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00675.x · Cited by 32
Tsai, C., Hwang, J., Chiang, F., Wang, Y., Tseng, C.-D., Tseng, Y.-Z., & Lin, J.-L. (2008) · Cardiology · doi:10.1159/000113419 · Cited by 32
Mastronicola, D., Arcuri, E., Arese, M., Bacchi, A., Mercadante, S., Cardelli, P., Citro, G., & Sarti, P. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4371-x · Cited by 32
Atrial fibrillation: A progressive atrial myopathy or a distinct disease?
Kallergis, E. M., Goudis, C. A., & Vardas, P. E. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.12.009 · Cited by 32
Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis
Qiang, H., Lin, Y., Zhang, X., Zeng, X. Y., Shi, J. G., Chen, Y.-X., Yang, M.-F., Han, Z., & Xie, W. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01353.x · Cited by 32
Non-ion channel blockers as anti-arrhythmic drugs (reversal of structural remodeling)
GOETTE, A., Bukowska, A., & Lendeckel, U. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.09.006 · Cited by 32
Chen, C., Lin, J.-L., Lai, L., Pan, C., Huang, S. K. S., & Lin, C.-S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.017 · Cited by 32
Treatment and prevention of atrial fibrillation with nonantiarrhythmic pharmacologic therapy
Lozano, H. F., Conde, C. A., Florin, T., & Lamas, G. A. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2005.05.020 · Cited by 32
Fiala, M., Wichterle, D., Chovančík, J., Bulková, V., Wojnarová, D., Nevřalová, R., & Januška, J. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02646.x · Cited by 31
Anti-arrhythmic strategies for atrial fibrillation
Grandi, E., & Maleckar, M. M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.09.012 · Cited by 32
Kiuchi, M. G., Chen, S., Silva, G. R. E., Paz, L. M. R., Kiuchi, T., Filho, A. G. D. P., & Souto, G. L. L. (2016) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-016-0186-6 · Cited by 31
Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards
Quah, J. X., Dharmaprani, D., Tiver, K. D., Lahiri, A., Hecker, T., Perry, R., Selvanayagam, J. B., Joseph, M. X., McGavigan, A. D., & Ganesan, A. N. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14987 · Cited by 32
Hypertension and atrial fibrillation
Go, O., & Rosendorff, C. (2009) · Current Cardiology Reports · doi:10.1007/s11886-009-0062-4 · Cited by 31
van Brakel, T. J., van der Krieken, T. E., Westra, S. W., van der Laak, J. A. W. M., Smeets, J. L. R. M., & van Swieten, H. A. (2013) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-013-9820-8 · Cited by 31
Relation of Renal Function to Risk for Incident Atrial Fibrillation in Women
Sandhu, R. K., Kurth, T., Conen, D., Cook, N. R., Ridker, P. M., & Albert, C. M. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.10.006 · Cited by 31
Chilukoti, R. K., Mostertz, J., Bukowska, A., Aderkast, C., Felix, S. B., Busch, M., Völker, U., Goette, A., Wolke, C., Homuth, G., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.007 · Cited by 31
Arrhythmias in Chronic Kidney Disease
Akhtar, Z., Leung, L. W. M., Kontogiannis, C., Chung, I., Waleed, K. B., & Gallagher, M. M. (2022) · European Cardiology Review · doi:10.15420/ecr.2021.52 · Cited by 30
van der Burgh, A. C., Geurts, S., Ikram, M. A., Hoorn, E. J., Kavousi, M., & Chaker, L. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025303 · Cited by 30
Liu, E., Shengrong, Y., Zhao, X., Li, J., Yang, W., & Li, G. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2009.12.020 · Cited by 30
Wożakowska−Kapłon, B., Bartkowiak, R., & Janiszewska, G. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02673.x · Cited by 30
Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity
DeSantiago, J., Bare, D. J., Varma, D., Solaro, R. J., Arora, R., & Banach, K. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.03.041 · Cited by 29
WNT signaling in atrial fibrillation
Wolke, C., Antileo, E., & Lendeckel, U. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221994086 · Cited by 29
Watanabe, H., Kaiser, D. W., Makino, S., MacRae, C. A., Ellinor, P. T., Wasserman, B. S., Kannankeril, P. J., Donahue, B. S., Roden, D. M., & Darbar, D. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.05.014 · Cited by 29
Dagres, N. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl190 · Cited by 29
Interactions between atrial fibrosis and inflammation in atrial fibrillation
Pang, Z., Ren, Y., & Yao, Z. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1578148 · Cited by 31
Huang, M., Gai, X., Yang, X., Hou, J., Lan, X., Zheng, W., Chen, F., & He, J. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2009.023 · Cited by 28
Whole Blood Gene Expression and Atrial Fibrillation: The Framingham Heart Study
Lin, H., Yin, X., Lunetta, K. L., Dupuis, J., McManus, D. D., Lubitz, S. A., Magnani, J. W., Joehanes, R., Munson, P. J., Larson, M. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096794 · Cited by 26
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castellà, M., Dan, G., Dilaveris, P., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 34
Fujita, M., Cheng, X. W., Inden, Y., Shimano, M., Yoshida, N., Inoue, A., Yamamoto, T., Takeshita, K., Kyo, S., Taguchi, N., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000503 · Cited by 27
Chen, J., Guo, Y., Chen, Q., Cheng, X., Xiang, G., Chen, M., Wu, H., Huang, Q., Zhu, P., & Zhang, J. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14165 · Cited by 27
LALLY, J. A., Gnall, E., Seltzer, J. H., & Kowey, P. R. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00874.x · Cited by 27
Antiarrhythmic potential of aldosterone antagonists in atrial fibrillation
Dąbrowski, R., & Szwed, H. (2012) · Cardiology Journal · doi:10.5603/cj.2012.0043 · Cited by 26
Huang, C., Nithiyanantham, S., Liao, J. Y., & Lin, W. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2019.11.002 · Cited by 26
Čarná, Z., & Osmancik, P. P. (2021) · Physiological Research · doi:10.33549/physiolres.934744 · Cited by 26
Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese
Wang, Q., Li, Y., Chen, X., Yu, J., Wang, J., Sun, J., Lu, S.-B., Li, J., & Wang, X. (2009) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2009.09.009 · Cited by 26
Antiarrhythmic Drug Therapy for Atrial Fibrillation: Focus on Atrial Selectivity and Safety
Li, D., Sun, H., & Lévesque, P. (2009) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152509787047621 · Cited by 26
Role of Angiotensin Receptor Blockers in the Prevention and Treatment of Arrhythmias
Garg, S., Narula, J., Marelli, C., & Cesario, D. A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.10.028 · Cited by 26
Ueng, K.-C., Tsai, T. P., & Yu, W. C. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.03.015 · Cited by 26
Lin, T., Yang, Y., Liao, M., Tsai, C., Hwang, J., Chiang, F., Chen, P., Lin, J.-L., & Lin, L. (2015) · Kidney International · doi:10.1038/ki.2015.96 · Cited by 25
Galzerano, D., Michele, S. D., Paolisso, G., Tuccillo, B., Lama, D., Carbotta, S., Cittadini, A., Tedesco, M. A., & Gaudio, C. (2012) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312443909 · Cited by 26
ACE phenotyping in human heart
Tikhomirova, V. E., Kost, O. A., Kryukova, O. V., Golukhova, E. Z., Bulaeva, N. I., Zholbaeva, A. Z., Bokeria, L. A., Garcia, J. G. N., & Danilov, S. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181976 · Cited by 24
Geurts, S., van der Burgh, A. C., Bos, M. M., Ikram, M. A., Stricker, B. H. C., Deckers, J. W., Hoorn, E. J., Chaker, L., & Kavousi, M. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.03.004 · Cited by 24
Deng, H., Shantsila, A., Xue, Y., Bai, Y., Guo, P., Potpara, T., Zhan, X., Fang, X., Liao, H., Wu, S., et al. (2019) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2019.02.006 · Cited by 24
Kiyosawa, N., Watanabe, K., MORISHIMA, Y., Yamashita, T., Yagi, N., Arita, T., Otsuka, T., & Suzuki, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072444 · Cited by 24
Cao, H., Xue, L., Wu, Y., Ma, H., Chen, L., Wang, X., Zhu, Q., Dai, N., & Chen, Y. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.019 · Cited by 24
Choudhury, A., Varughese, G. I., & Lip, G. Y. H. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.13.2193 · Cited by 23
Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway
Weber, S., Meyer-Roxlau, S., & El‐Armouche, A. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.09.007 · Cited by 22
How to detect atrial fibrosis.
Lacalzada-Almeida, J. B., & García‐Niebla, J. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.03.008 · Cited by 23
Okamoto, Y., Nagasawa, Y., Obara, Y., Ishii, K., Takagi, D., & Ono, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007416 · Cited by 23
Biomarkers in Atrial Fibrillation, Ventricular Arrhythmias, and Sudden Cardiac Death
Mountantonakis, S., & Deo, R. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00238.x · Cited by 23
Berkowitsch, A., Neumann, T., Kuniss, M., Janin, S., Wójcik, M., Zaltsberg, S., Mitrović, V. L., & PITSCHNER, H. F. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02769.x · Cited by 23
Kimura, M., Ogawa, H., Wakeyama, T., Takaki, A., Iwami, T., Hadano, Y., Mochizuki, M., Hiratsuka, A., Shimizu, A., & Matsuzaki, M. (2010) · Journal of Cardiology · doi:10.1016/j.jjcc.2010.11.006 · Cited by 23
Bhuriya, R., Singh, M., Sethi, A., Molnár, J., Bahekar, A., Singh, P. P., Khosla, S., & Arora, R. R. (2011) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410389045 · Cited by 22
Venous Congestion and Systemic Hypoperfusion in Cardiorenal Syndrome: Two Sides of the Same Coin
Scagliola, R., & Brunelli, C. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2303111 · Cited by 23
Atrial fibrillation: insights from clinical trials and novel treatment options
Blaauw, Y., & Crijns, H. J. G. M. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01885.x · Cited by 22
Huang, F., Liu, X., Liu, J.-J., Xie, Y., Zhao, L., Liu, D., Zeng, Z., Liu, X., Zheng, S., & Xiao, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1148410 · Cited by 21
Pillarisetti, J., Patel, A., Boc, K. P., Bommana, S., Sawers, Y., Vanga, S., Sayana, H. P., Chen, W., Nath, J., Vacek, J. L., et al. (2009) · Europe PMC (PubMed Central) · doi:10.4022/jafib.191 · Cited by 21
Danilov, S. M. (2017) · Molecular Biology · doi:10.1134/s0026893317060048 · Cited by 21
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
Nakanishi, T., Baldwin, H. S., Fineman, J. R., & Yamagishi, H. (2020) · Springer eBooks · doi:10.1007/978-981-15-1185-1 · Cited by 21
Mechanisms of Onset of Atrial Fibrillation:
Guyomar, Y., THOMAS, O., Marquié, C., Jarwe, M., Klug, D., Kacet, S., CARLIOZ, R., Ferrier, A., Fossati, F., GUÉRIN, S., et al. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00191.x · Cited by 21
Current Perspectives of Electrical Remodeling and Its Therapeutic Implications
Wasson, S., Reddy, H. K., & Dohrmann, M. L. (2004) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424840400900208 · Cited by 21
Pak, H., Kim, J. S., Shin, S. Y., Lee, H. S., Choi, J., Lim, H. E., Hwang, C., & Kim, Y. (2008) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.01074.x · Cited by 21
Palardy, M., Ducharme, A., Nattel, S., Tardif, J., White, M., Racine, N., Tétreault, K., Dabouz, F., Talajic, M. R., & Roy, D. (2008) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(08)70670-6 · Cited by 21
Heart-specific overexpression of (pro)renin receptor induces atrial fibrillation in mice
Lian, H., Wang, X., Wang, J., Liu, N., Zhang, L., Lu, Y., Yang, Y., & Zhang, L. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.01.088 · Cited by 19
Bukowska, A., Röcken, C., Erxleben, M., Röhl, F., Hammwöhner, M., Huth, C., Ebert, M. P. A., Lendeckel, U., & Goette, A. (2009) · Cardiovascular Pathology · doi:10.1016/j.carpath.2008.12.014 · Cited by 20
Lévy, S. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0480 · Cited by 20
Atrial fibrillation in essential hypertension
Zhao, L., & Liu, S. (2014) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e3283640ff7 · Cited by 20
Güler, N., Özkara, C., Dülger, H., Kutay, V., Şahin, M., Erbilen, E., & Gümrükçüoğlu, H. A. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.08.040 · Cited by 20
Informe del Grupo de Trabajo para la elaboración de guías de práctica clínica del American College of Cardiology y de la American Heart Association, del Comité de Guías de Práctica Clínica de la Sociedad Europea de Cardiología (comité de redacción para la revisión de la Guía de práctica clínica sobre el manejo de pacientes con fibrilación auricular, 2., & Desarrollado en colaboración con las asociaciones European Heart Rhythm Association y Heart Rhythm Society (2006) · Revista Española de Cardiología · doi:10.1157/13096583 · Cited by 20
CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling
Wang, Y., Wang, J., Shi, L., Chen, X., Li, D., Chen, C., Yang, K., Lu, M., Huang, J., Zhang, L., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.062660 · Cited by 19
Chrysostomakis, S. I., Karalis, I. K., SIMANTIRAKIS, E. N., Koutsopoulos, A. V., Mavrakis, H. E., CHLOUVERAKIS, G. I., & Vardas, P. E. (2007) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-007-6053-z · Cited by 19
Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
Howlett, P. J., Hatch, F., Alexeenko, V., Jabr, R. I., Leatham, E. W., & Fry, C. H. (2015) · BioMed Research International · doi:10.1155/2015/910267 · Cited by 19
Clinical trials, the renin angiotensin system and atrial fibrillation
Birnie, D. H., Gollob, M. H., & Healey, J. S. (2006) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000231408.69307.9b · Cited by 18
Blockade of atrial angiotensin II type 1 receptors
Klein, H., & Goette, A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00469-8 · Cited by 19
Atrial flutter/fibrillation in patients receiving transcatheter closure of atrial septal defect
Chiu, S., Wu, M., Tsai, C., Lai, L., Lin, J.-L., Lin, M., Lu, C., & Wang, J. (2016) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2016.09.005 · Cited by 18
Mechanism and Prevention of Atrial Remodeling and Their Related Genes in Cardiovascular Disorders
Sandeep, B., Ding, W., Huang, X., Liu, C., Wu, Q., Su, X., Gao, K., & Xiao, Z. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101414 · Cited by 18
Kataoka, T., Hamasaki, S., Inoue, K., Yuasa, T., Tomita, K., Ishida, S., Ogawa, M., Saihara, K., Koriyama, C., Nobuyoshi, M., et al. (2009) · Journal of Cardiology · doi:10.1016/j.jjcc.2009.11.007 · Cited by 18
Komatsu, T., Tachibana, H., Satō, Y., Ozawa, M., Kunugida, F., Orii, M., & Nakamura, M. (2009) · International Heart Journal · doi:10.1536/ihj.50.465 · Cited by 18
Papila-Topal, N., Özben, B., Hançer, V. S., Tanrikulu, A. M., Küçükkaya, R. D., Fak, A. S., Başaran, Y., & Yeşildağ, O. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320311399605 · Cited by 18
Coppini, R., Santini, L., Palandri, C., Sartiani, L., Cerbai, E., & Raimondi, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01420 · Cited by 19
Varga, C. R., Cleland, J. G. F., Abraham, W. T., Lip, G. Y. H., Leyva, F., & Hatamizadeh, P. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.05.081 · Cited by 17
He, W., ZHUANG, Y., Wang, L., Qi, L., CHEN, B., Wang, M., Shao, D., & Chen, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4069 · Cited by 17
Bidirectional association between atrial fibrillation and congestive heart failure in the elderly
O’Neal, W. T., Qureshi, W., Zhang, Z., & Soliman, E. Z. (2016) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000289 · Cited by 17
Jiao, K., Li, G., Zhang, P., Chen, R., & Yu, Y. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01502.x · Cited by 16
Yoon, N., Cho, J. G., Kim, K. H., Park, K. H., Sim, D. S., Yoon, H. J., Hong, Y. J., Park, H. W., Kim, J. H., Ahn, Y., et al. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.920 · Cited by 16
Santoro, D., Gembillo, G., & Andò, G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051466 · Cited by 16
Biomarkers in the clinical management of patients with atrial fibrillation and heart failure.
Koniari, I. C., Artopoulou, E., Velissaris, D., Ainslie, M., Mplani, V., Karavasili, G., Kounis, N. G., & Tsigkas, G. (2021) · PubMed Central · doi:10.11909/j.issn.1671-5411.2021.11.010 · Cited by 16
Demers, J., Ton, A., Huynh, F., Thibault, S., Ducharme, A., Paradis, P., Nemer, M. J., & Fiset, C. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023974 · Cited by 16
Review: Atrial fibrillation and renin-angiotensin system
Serra, J. L. P., & Bendersky, M. (2008) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944708092111 · Cited by 16
New strategies in the surgical treatment of atrial fibrillation
Sie, H. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00350-x · Cited by 17
Tziakas, D. N., Chalikias, G. K., Stakos, D., Papazoglou, D., Παπάνας, Ν., Papatheodorou, K., Chatzikyriakou, S. V., Kotsiou, S., Maltezos, E. S., & Boudoulas, H. K. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.14.2225 · Cited by 16
Chang, C. D., Zhang, C., Zhao, X., Kuang, X., Tang, H., & Xiao, X. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.05.028 · Cited by 15
Cheng, W. N., Zhu, Y., & Wang, H. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4862 · Cited by 15
Tadic, M. V., Ivanovic, B. A., & Cuspidi, C. (2013) · Blood Pressure · doi:10.3109/08037051.2013.814234 · Cited by 13
Atrial Remodeling And Atrial Fibrillation: Mechanistic Interactions And Clinical Implications.
Ghamdi, B. A., & Hassan, W. (2009) · Europe PMC (PubMed Central) · doi:10.4022/jafib.125 · Cited by 15
Tanabe, Y., Kawamura, Y., Sakamoto, N., Sato, N., Kikuchi, K., & Hasebe, N. (2009) · International Heart Journal · doi:10.1536/ihj.50.445 · Cited by 15
Inhibition of the Renin-Angiotensin System for Prevention of Atrial Fibrillation
Zografos, T. A., & Katritsis, D. G. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02832.x · Cited by 15
Klemm, H. U., Heitzer, T. A., Ruprecht, U., Meinertz, T., & Ventura, R. (2010) · Cardiology · doi:10.1159/000318016 · Cited by 15
Metadata
- Authors
- Goette, A., Staack, T., Röcken, C., Arndt, M., Geller, J. C., Huth, C., Ansorge, S., Klein, H. U., & Lendeckel, U.
- Affiliations
- University Hospital Magdeburg (DE)
- Corresponding author
- Goette, Andreas
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 35
- Issue
- 6
- Pages
- 1669-1677
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2038843437
- Cited by
- 583
- References
- 47
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 17 · 2020: 15 · 2019: 17 · 2018: 10 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 23 · 2013: 24 · 2012: 27
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, extracellular signal-regulated kinase, ERK1/ERK2, angiotensin-converting enzyme, atrial fibrosis, MEK1/2, interstitial cells, chronic atrial fibrillation, paroxysmal atrial fibrillation, ACE inhibitors, MAPK signaling
- MeSH terms
- Aged, Atrial Fibrillation, Endomyocardial Fibrosis, Female, Heart Atria, Humans, Peptidyl-Dipeptidase A, Male, Middle Aged, RNA, Messenger, Gene Expression Regulation, Enzymologic, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
